Organizers:

   Alfonso Valencia (CNB-Madrid)
   Luis Serrano (EMBL-Heidelberg)
   Paulino Gomez-Puertas (CAB-Madrid)
   Shoshana Wodak (SCMBB-Bruxelles)

    e-mail: workshop2002@gredos.cnb.uam.es
 

Background:

With all the new information available about genomes and proteomes, it is possible to conceive of genes and proteins more as part of a network than as isolated entities. Molecular function becomes then a function of cellular context and not only an individual property. The current efforts for the analysis of protein-protein interactions can be considered as the first steps towards the construction of interaction networks.

The ESF program on "Integrated Approaches for Functional Genomics" was designed to address questions related to this new scenario, including the development of new techniques, the analysis of standards for data integration and manipulation and ultimately for discussing how this accumulated information would be used to obtain new knowledge.

In this sense, this proposal addresses directly the problem of the manipulation of information about interactions and regulation of networks at the system level.
In biology this type of problem has previously been addressed by the community focusing on metabolic pathways, while in other areas such as engineering and computer science interesting developments include electrical circuits and logical systems. These communities have very different viewpoints and in general lack direct access to new technologies and recent proteomics data. The intention of the workshop is to create a favorable arena for the interchange of ideas and the promotion of true scientific development, responding to a real need for trans-disciplinary approaches.
 

Venue: Granada, Spain. Hotel: ALIXARES ***

Dates: 12th - 14th June, 2002 (delegates to arrive on the 11th)

Attendance: It is expected that about 30 people will be invited to attend.
 

Speakers:

• Uri Alon. Weizmann Institute of Science. Rehovot, Israel.
Design principles of  transcriptional networks.
• Alvis Brazma.  European Bioinformatics Institute. Cambridge, UK.
Building and analysing genome scale expression networks for yeast.
• Marta Cascante. University of Barcelona. Barcelona, Spain.
Modelling metabolic networks in drug discovery and disease.
• Duncan Davidson. MRC Human Genetics Unit. Edinburg, UK.
Molecular networks in the context of the whole organism.
• Joaquin Dopazo.  CNIO-Spanish National Cancer Center. Madrid, Spain.
Inference of positive and negative transcriptional regulation from gene expression data.
• Marcelle Kaufman. Université Libre de Bruxelles. Bruxelles, Belgium.
• Jan Komorowski. Norwegian University of Science and Technology. Trondheim, Norway.
• Victor de Lorenzo. CNB-National Center of Biotechnology. Madrid, Spain.
Microbial diversity in action: too big a party.
• Christos Ouzounis.  European Bioinformatics Institute. Cambridge, UK.
Computational genomics.
• Vincent Schachter. Hybrigenics SA. Paris, France.
Construction, prediction and analysis of protein interaction networks.
• Luis Serrano. European Molecular Biology Laboratory. Heidelberg, Germany.
Simple gene networks.
• Giulio Superti-Furga.  Cellzome & EMBL. Heidelberg, Germany.
Charting eukaryotic proteomes by the analysis of protein complexes.
• Alfonso Valencia  CNB-National Center of Biotechnology. Madrid, Spain.
• Hans Westerhoff. Vrije Universiteit Amsterdam, The Netherlands.
Attractive models: how to make the Silicon cell relevant and dynamic.
• Shoshana Wodak. Université Libre de Bruxelles. Bruxelles, Belgium.
Representing and analysing information on networks of cellular processes.

Programme:

 

Day 1 (11th)		Arrivals and accommodation. Dinner (19:30 - 22:00).
Day 2 (12th)	9:00	Welcome and introduction.
	9:30	Combining theoretical and experimental approaches (I). Chairman: Luis Serrano.   9:30 Vincent Schachter.  Construction, prediction and analysis of protein interaction networks. 10:15 Giulio Superti-Furga. Charting eukaryotic proteomes by the analysis of protein complexes. (11:00 coffee break) 11:30 Alvis Brazma. Building and analysing genome scale expression networks for yeast. 12:15 Shoshana Wodak. Representing and analysing information on networks of cellular processes.
	13:00	lunch
	16:00	Combining theoretical and experimental approaches (II). Chairman: Shoshana Wodak. 16:00 Uri Alon. Design principles of  transcriptional networks. 16:45 Luis Serrano. Simple gene networks. (17:30 coffee break) 17:45. Short talks & open discussion.
	20:00	dinner
	22:00	nocturnal visit to the Alhambra palace [photo gallery]
Day 3 (13th)	9:30	Networks and computer simulation (I). Chairman: Hans Westerhoff.   9:30 Marcelle Kaufman. 10:15 Jan Komorowski. (11:00 coffee break) 11:30 Duncan Davidson. Molecular networks in the context of the whole organism. 12:15 Alfonso Valencia
	13:00	lunch
	16:00	Networks and computer simulation  (II). Chairman: Alfonso Valencia. 16:00 Joaquin Dopazo. Inference of positive and negative transcriptional regulation from gene expression data. 16:45 Marta Cascante. Modelling metabolic networks in drug discovery and disease. (17:30 coffee break) 17:45. Short talks & open discussion.
	20:00	dinner
Day 4 (14th)	9:30	Assembling the puzzle. Chairman: Victor de Lorenzo.   9:30 Victor de Lorenzo. Microbial diversity in action: too big a party. 10:15 Christos Ouzounis. Computational genomics. (11:00 coffee break) 11:30 Hans Westerhoff. Attractive models: how to make the Silicon cell relevant and dynamic. 12:15 Open discussion & conclusions.
	13:30	lunch
		Departures.

REGISTRATION:

Sorry, registrations are already CLOSED for this event.

SEND an e-mail to: workshop2002@gredos.cnb.uam.es, (subject: Registration) including:
 
• Your full name and position.
• Your email address.
• Your complete address (including phone and fax number).
• Your work place (including the name of  your supervisor and the web site of your group, if any).
• 3 relevant publications.
• 20 lines indicating the reasons why you think this workshop would be useful to you.

• Delegates will be selected by the organising committee on the basis of their CV and scientific interests.
• Everybody will be accommodated in Hotel Alixares, which is situated next to the Alhambra Palace in Granada.
• ACCESS TO THE HOTEL

Further information, please contact:

workshop2002@gredos.cnb.uam.es (workshop local organizers) or

 

Annette Martin (ESF functional genomics programme administrator).

 

Links:

• RENFE (Railroads)

 
• IBERIA airline.

 
• Granada: map and tourist information.

 
• ALIXARES Hotel.