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CATH - Protein Structure Classification

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Main classification levels

class1 Class 1: Mainly Alpha

class2 Class 2: Mainly Beta

class3 Class 3: Mixed Alpha-Beta

class4 Class 4: Few Secondary Structures

Introduction

CATH is a novel hierarchical classification of protein domain structures, which clusters proteins at four major levels, Class(C), Architecture(A), Topology(T) and Homologous superfamily (H)

Class, derived from secondary structure content, is assigned for more than 90% of protein structures automatically. Architecture, which describes the gross orientation of secondary structures, independent of connectivities, is currently assigned manually. The topology level clusters structures according to their toplogical connections and numbers of secondary structures. The homologous superfamilies cluster proteins with highly similar structures and functions. The assignments of structures to toplogy families and homologous superfamilies are made by sequence and structure comparisons.
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Preliminary data

class5 Class 5: Multi domain

class6 Class 6: Preliminary single domain assignments

class7 Class 7: Psi blast sequence families

class8 Class 8: CATH-35 Sequence families

class9 Class 9: Fragments from multi-chain domains

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