Search Glaxo Wellcome

Glaxo Wellcome
Pharmacology Guide

Neurotransmitters and other chemical signalling agents

Precursors: Tyrosine (a) -> L-dihydroxyphenylalanine (L-DOPA)
(b) -7gt; dopamine
Synthesising enzymes: (a) Tyrosine hydroxylase;
(b) L-aromatic amino-acid decarboxylase (DOPA decarboxylase)
Metabolising enzymes: MAO and catechol-O-methyl transferase (COMT)
Metabolite: 3,4-Dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)
Receptor subtypes Agonists Antagonists Second messenger
D1 SKF 38393 Sch 23390 (+ve) cAMP
D2 Quinpirole Sulpiride (+ve)gK+
D3 7-OH-DPAT AJ-76 ?
D4 Dopamine Clozapine ?
D5 Dopamine Sch 23390 (+ve)cAMP

NB: (+ve) indicates increase; (-ve) indicates decrease.

Sibley, D.R. (1991) Trends Pharmacol. Sci. 12, 7 - 9.
Van Tol, H.H.M. et al. (1991) Nature 350, 610 - 614.
Sunahara, R.K. et al. (1991) Nature 350, 614 - 619.

Forward  Endothelin
Back  Cholecystokinin
Return  Table of Contents

Our World Bookmark News Healthcare Download Science Contact Home page