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Glaxo Wellcome
Pharmacology Guide

Neurotransmitters and other chemical signalling agents

ENDOTHELIN (ET)
Precursors: preproET-1 etc.
Synthesising enzymes: "endothelin converting enzyme"
Metabolising enzymes: not known
 
Receptor subtypes Agonists Antagonists Second messenger
ET(A) ET-1, ET-2 FR139317, BQ123 PI
ET(B) Sarafotoxin S6C,
[Ala(1),(3),(11),(15)] ET-1,
BQ 3020
IRL 1038 PI
ET(C) MB

NB: (+ve) indicates increase; (-ve) indicates decrease.

Reviews
Sakurai, T., Yanagisawa, M. and Masaki, T. (1992) Trends Pharmacol. Sci. 13, 103-108.


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