In vitro pharmacology: common isolated tissue preparations
| Preparation | Receptors commonly studied | Bathing Solution * |
|---|---|---|
| Frog rectus abdominis | ACh (nicotinic, muscle-type) | Frog Ringer |
| Guinea-pig ascending colon | 5HT(4) | Krebs' |
| Guinea-pig ileum | ACh (muscarinic M(3)), histamine H(1) & H(3), neurokinin NK(1), bradykinin B(2), 5HT(3), CCK(A), CCK(B), Angiotensin AT(2) |
Krebs' or Tyrode |
| Guinea-pig ileum (fd smd.) |
mu- and kappa-opioid, alpha(2)-adrenoceptors |
Krebs' or Tyrode |
| Guinea-pig vas deferens | EP(3) | Krebs' |
| Mouse vas deferens (fd smd.) | mu- kappa- and delta-opioid, dopamine D(2) |
Krebs' (minus Mg(2+)) |
| Rabbit jejunum | alpha(2)-adrenoceptors | Tyrode |
| Rabbit heart Langendorff |
beta(1)-adrenoceptors | Ringer-Locke |
| Rat anococcygeus | alpha(1)-adrenoceptors, GABA(B) |
Krebs' |
| Rat or Rabbit aorta | alpha(1)-adrenoceptors, 5HT(2), neurokinin NK(1), bradykinin B(1), angiotensin AT(1), CGRP(1) |
Krebs' |
| Rat atrium | beta(1)-adrenoceptors, ACh (muscarinic), M(2) |
Krebs' |
| Rat colon | Neurokinin NK(2) | Krebs' |
| Rat phrenic nerve/diaphragm |
ACh (nicotinic) | Krebs' |
| Rat portal vein | Neurokinin NK(3) | Krebs' |
| Rat uterus | beta(2)-adrenoceptors, histamine H(2), bradykinin B(2) |
De Jalon |
| Rat vas deferens (field-stimulated) |
alpha(2)-adrenoceptors, mu-opioid, prostanoid EP(3)bradykinin B(2), CGRP(2) |
Krebs' (minus Mg(2+)) |
* - Commonly but not exclusively used
fd smd - (field stimulated)
Physiological
salt solutions
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