Neurotransmitters and other chemical signalling agents
| ATP (P2 purinoceptors) | |||
|---|---|---|---|
| Precursors: | Normal cellular constituent; formed from ADP | ||
| Synthesising enzymes: | Phosphorylases | ||
| Metabolising enzymes: | Phosphatases | ||
| Metabolites: | ADP, AMP, adenosine, inosine | ||
| Receptor subtypes | Agonists | Antagonists | Second messenger |
| P2X | beta-gamma-Me-ATP | alpha-beta-Me-ATP (desensitises) suramin |
(+ve)g(cation) or (up)gCa2+ |
| P2Y | ADP-beta-F, 2-Me-S-ATP |
Reactive blue 2, suramin |
PI, (+ve)gK |
| P2T (platelet) | ADP | Suramin, AMP | (-ve) cAMP, (+ve)g(cation) |
| P2Z (mast cell) |
ATP4- | none | ? |
| P2U | UTP | none | PI |
NB: (+ve) indicates increase; (-ve) indicates decrease.
Reviews
Kennedy, C. (1990) Arch. Int. Pharmacodyn. Ther. 303, 30-50.
Bradykinin
Angiotensin
II
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