The E-value is an estimate of approximately how many sequences would score this well by chance in the database searched. For SAM-T99, E-values less than about 0.01 are roughly equivalent, as sequences that score that well have most likely already been included in the SAM-T99 multiple alignment. Database: PDB (updated Fri Dec 22 07:54:10 2000) Score method: template Summary of Database Hits: Template SeqID Reverse EValue SeqLabel 1by2 -44.6 4e-16