BLASTP2 Result
of 
Bork Group's Advanced BLAST2 Search Service at 
EMBL.
back to BLAST2
BLASTP 2.0MP-WashU [16-Dec-1999] [irix6-r10k-L64 23:35:48 16-Dec-1999]
Copyright (C) 1996-1999 Washington University, Saint Louis, Missouri USA.
All Rights Reserved.
Reference: Gish, W. (1996-1999) http://blast.wustl.edu
Query= query_sequence
(416 letters)
Echofilter:
>Filtered+0
MDEADXXXXXXXXXXXVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
Database: nrdb-95% Rel.02.04.2003
701,238 sequences; 229,823,634 total letters.
Searching....10....20....30....40....50....60....70....80....90....100% done
Query sequence and locally-aligned HSPs from database sequences
0 90 180 270 360
| | | | | |416
query_sequence | __________________________________________________
^ v swissnew|P55211|IC | _________________________________________________
^ v sptrembl|Q9R0T0|Q9 | _________________________________________________
^ v sptrembl|Q9JHK1|Q9 | _________________________________________________
^ v trembl|AB015653|AB | ________________ _______________
^ v sptrembl|Q90WU0|Q9 | ___________________________________________
^ v sptrembl|Q9IB63|Q9 | _______________________________________________
^ v sptrembl|Q99M88|Q9 | __________________________________
^ v trembl|U64963|GGU6 | ______________________________________________
^ v swissnew|Q60431|IC | __________________ _________
^ v sptrembl|Q8JGM9|Q8 | _____________________________
^ v sptrembl|Q8ITP3|Q8 | ___________________________
^ v sptrembl|Q8CHV5|Q8 | __________________ __________
^ v sptrembl|Q8MJU1|Q8 | __________________ __________
^ v sptrembl|Q95ND5|Q9 | __________________ __________
^ v swissnew|P42574|IC | __________________ __________
^ v sptrembl|Q8I6Y2|Q8 | ___________________________________________
^ v swissnew|P55213|IC | __________________ __________
^ v sptrembl|Q8MJC3|Q8 | __________________ ___________
^ v sptrembl|Q9IB67|Q9 | ______________________________________________
^ v sptrembl|Q9JHX4|Q9 | ________________________________
^ v sptrembl|Q8MKI5|Q8 | __________________ _______
^ v sptrembl|Q8K241|Q8 | ______________________________________________
^ v sptrembl|O93417|O9 | __________________ _________
^ v tremblnew|AB090853 | ___________________ _________
^ v sptrembl|Q8JIS9|Q8 | __________________ ___________
^ v swissnew|P42573|CE | ________ ______________________________
^ v sptrembl|Q8JIS8|Q8 | _________________ ___________
^ v sptrembl|Q90WU1|Q9 | _______________________________________________
^ v sptrembl|O77623|O7 | __________________ ___
^ v swissnew|P45436|CE | ________ ______________________________
^ v sptrembl|Q9I8J3|Q9 | _______________________________
^ v pironly|T20038|T20 | ________ ____________________________
^ v swissnew|P55866|IC | _________________ ___________
^ v swissnew|P42575|IC | ______________________________
^ v trembl|AB038985|AB | _______________________________
^ v trembl|AF422925|AF | _______________________________
^ v swissnew|O89110|IC | _______________________________
^ v swissnew|O02002|IC | ___________________________
^ v sptremblnew|AAH450 | _______________________________________
^ v swissnew|O01382|IC | ___ _________________ ______
^ v swissnew|P55215|IC | ____________________________________
^ v trembl|AF052645|AF | _________________ _________
^ v sptrembl|Q8I9V7|Q8 | _________________ ______
^ v trembl|X98174|HSMA | __________________________
^ v swissnew|P89116|IC | __________________ ______
^ v sptrembl|Q9IB65|Q9 | ______________________________
^ v sptrembl|Q9IB62|Q9 | ________________ ____________
^ v sptrembl|Q9GV88|Q9 | _______________________________
^ v trembl|U13022|HS13 | ________________
^ v swissnew|P55214|IC | _______________________________
Alignments:
^ = swissnew|P55211|ICE9_HUMAN Caspase-9 precursor (EC 3.4.22.-) (CASP-9)
(ICE-like apoptotic protease 6) (ICE-LAP6) (Apoptotic protease
Mch-6) (Apoptotic protease activating factor 3)
(APAF-3).//:swiss|P55211|ICE9_HUMAN Caspase-9 precursor (EC
3.4.22.-) (CASP-9) (ICE-like apoptotic protease 6) (ICE-LAP6)
(Apoptotic protease Mch-6) (Apoptotic protease activating factor 3)
(APAF-3).//:trembl|AL512883|AL512883_4 gene: "CASP9"; product:
"bA265F14.4 (caspase 9, apoptosis-related cysteine protease
(MCH6))"; Human DNA sequence from clone RP11-265F14 on chromosome
1. Contains the CTRC gene for chymotrypsin C (caldecrin), the genes
for Elastase 2A and 2B, the CASP9 gene for caspase 9,
apoptosis-related cysteine protease (MCH6) and part of the gene for
a novel protein similar to DNAJ. Contains ESTs, STSs, GSSs and two
CpG islands. //:trembl|BC002452|BC002452_1 product: "caspase 9,
apoptosis-related cysteine protease"; Homo sapiens, caspase 9,
apoptosis-related cysteine protease, clone MGC:3054 IMAGE:3343958,
mRNA, complete cds. //:trembl|BC006463|BC006463_1 product: "Unknown
(protein for MGC:2105)"; Homo sapiens, clone MGC:2105
IMAGE:3542075, mRNA, complete cds. //:gp|AL512883|14530778
bA265F14.4 (caspase 9, apoptosis-related cysteine protease (MCH6))
[Homo sapiens]//:gp|BC002452|12803273 caspase 9, apoptosis-related
cysteine protease [Homo sapiens]//:gp|BC006463|13623673 Unknown
(protein for MGC:2105) [Homo sapiens]
Length = 416
0 90 180 270 360
| | | | | |416
swissnew|P55211|ICE9_ | __________________________________________________
Local hits (HSPs) | _________________________________________________
Score = 2111 (748.2 bits), Expect = 2.8e-218, P = 2.8e-218
Identities = 405/416 (97%), Positives = 405/416 (97%)
Query: 1 MDEADXXXXXXXXXXXVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
MDEAD VEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 61 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV 120
DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
Sbjct: 61 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV 120
Query: 121 LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR 180
LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR
Sbjct: 121 LRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTR 180
Query: 181 TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ 240
TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ
Sbjct: 181 TGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQ 240
Query: 241 ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS 300
ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS
Sbjct: 241 ASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVAS 300
Query: 301 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG 360
TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG
Sbjct: 301 TSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSG 360
Query: 361 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS 416
SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
Sbjct: 361 SWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS 416
^ = sptrembl|Q9R0T0|Q9R0T0 Caspase9.//:trembl|AB019600|AB019600_1 product:
"caspase9"; Mus musculus mRNA for caspase9, complete cds.
//:gp|AB019600|6440942 caspase9 [Mus musculus]
Length = 454
0 90 180 270 360 450
| | | | | |454
sptrembl|Q9R0T0|Q9R0T | __________________________________________________
Local hits (HSPs) | _________________________________________________
Score = 1288 (458.5 bits), Expect = 2.2e-166, Sum P(2) = 2.2e-166
Identities = 249/323 (77%), Positives = 270/323 (83%)
Query: 99 SKPTLENLTPVVLRPE----IR-KPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAY 153
S+P + NLTPVVL PE R KPEVLRPETPRPVDIGSGG DV +RG+AD+AY
Sbjct: 132 SQPAVGNLTPVVLGPEELWPARLKPEVLRPETPRPVDIGSGGAHDVCVPGKIRGHADMAY 191
Query: 154 ILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMV 213
L +PCGHCLIINNVNFC SGL TRTGSN+D +KL RF L FMVEVK DLTAKKMV
Sbjct: 192 TLDSDPCGHCLIINNVNFCPSSGLGTRTGSNLDRDKLEHRFRWLRFMVEVKNDLTAKKMV 251
Query: 214 LALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCP 273
AL+E+A ++H ALDC VVVILSHGCQASHLQFPGAVYGTDGC VS+EKIVNIFNG+ CP
Sbjct: 252 TALMEMAHRNHRALDCFVVVILSHGCQASHLQFPGAVYGTDGCSVSIEKIVNIFNGSGCP 311
Query: 274 SLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAIS 333
SLGGKPKLFFIQACGGEQKDHGFEVA TS + + S+ EPDA P+QEG R DQLDA+S
Sbjct: 312 SLGGKPKLFFIQACGGEQKDHGFEVACTSSQGRTLDSDSEPDAVPYQEGPRPLDQLDAVS 371
Query: 334 SLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSV 393
SLPTPSDI VSYSTFPGFVSWRD KSGSWY+ETLD I EQWA SEDLQSLLLRVANAVS
Sbjct: 372 SLPTPSDILVSYSTFPGFVSWRDKKSGSWYIETLDGILEQWARSEDLQSLLLRVANAVSE 431
Query: 394 KGIYKQMPGCFNFLRKKLFFKTS 416
KG YKQ+PGCFNFLRKKLFFKTS
Sbjct: 432 KGTYKQIPGCFNFLRKKLFFKTS 454
Score = 355 (130.0 bits), Expect = 2.2e-166, Sum P(2) = 2.2e-166
Identities = 83/140 (59%), Positives = 97/140 (69%)
Query: 1 MDEADXXXXXXXXXXXVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
MDEAD V ELQV +LWDALLSRELF MIEDIQ+AGSGSRRDQARQL+
Sbjct: 1 MDEADRQLLRRCRVRLVSELQVAELWDALLSRELFTRDMIEDIQQAGSGSRRDQARQLVT 60
Query: 61 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLS----KPTLENLTPVVLRP--- 113
DLETRG QALPLFISCLEDTGQ LAS L++ RQAAK KP L++L PVVL P
Sbjct: 61 DLETRGRQALPLFISCLEDTGQGTLASLLQSGRQAAKQDPEAVKP-LDHLVPVVLGPMGL 119
Query: 114 EIRKPEVLRPETPRPVDIGS 133
++ V++ E +P +G+
Sbjct: 120 TAKEQRVVKLEPSQPA-VGN 138
^ = sptrembl|Q9JHK1|Q9JHK1 Caspase-9 (Caspase-9 long
isoform).//:trembl|AF262319|AF262319_1 product: "caspase-9";
Rattus norvegicus caspase-9 mRNA, complete cds.
//:trembl|AF271996|AF271996_1 gene: "RNCASP9"; product:
"caspase-9"; Rattus norvegicus caspase-9 (RNCASP9) mRNA, complete
cds. //:trembl|AF286006|AF286006_1 product: "caspase-9 long
isoform"; Rattus norvegicus caspase-9 long isoform mRNA, complete
cds, alternatively spliced. //:trembl|AF308469|AF308469_1 product:
"caspase-9"; Rattus norvegicus caspase-9 mRNA, complete cds.
//:trembl|AY027667|AY027667_1 product: "caspase-9"; Rattus
norvegicus caspase-9 mRNA, complete cds. //:gp|AF271996|8515868
caspase-9 [Rattus norvegicus]//:gp|AF262319|9181863 caspase-9
[Rattus norvegicus]//:gp|AF286006|9802390 caspase-9 long isoform
[Rattus norvegicus]//:gp|AF308469|13625793 caspase-9 [Rattus
norvegicus]//:gp|AY027667|18450366 caspase-9 [Rattus norvegicus]
Length = 454
0 90 180 270 360 450
| | | | | |454
sptrembl|Q9JHK1|Q9JHK | __________________________________________________
Local hits (HSPs) | _________________________________________________
Score = 1290 (459.2 bits), Expect = 5.9e-166, Sum P(2) = 5.9e-166
Identities = 251/336 (74%), Positives = 277/336 (82%)
Query: 89 LRTNRQ-AAKL--SKPTLENLTPVVLRPE----IR-KPEVLRPETPRPVDIGSGGFGDVG 140
L++ Q KL S+P L NLTPVVL PE R +PEVL PETPRPVDIGSG DV
Sbjct: 119 LKSKEQKVVKLDPSQPALGNLTPVVLGPEELWPTRLRPEVLTPETPRPVDIGSGRAHDVC 178
Query: 141 ALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFM 200
+ +AD+AY L +PCGHCLIINNVNFC SGL TR GS++DCEKL+ RF L FM
Sbjct: 179 TPGKIERHADMAYTLDSDPCGHCLIINNVNFCPSSGLSTRIGSHVDCEKLQHRFCWLRFM 238
Query: 201 VEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSV 260
VEVK DLTAKKMV AL+E+A +DH ALDC VVVILSHGCQASHLQFPGAVYGTDGC VS+
Sbjct: 239 VEVKNDLTAKKMVTALMEMAHRDHRALDCFVVVILSHGCQASHLQFPGAVYGTDGCSVSI 298
Query: 261 EKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQ 320
E+IVNIFNGT CPSLGGKPKLFFIQACGGEQKDHGFEVA TS +D++ S+ EPDA P+Q
Sbjct: 299 ERIVNIFNGTGCPSLGGKPKLFFIQACGGEQKDHGFEVAFTSSQDKAFDSDSEPDAVPYQ 358
Query: 321 EGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDL 380
EG RT DQLDA+SSLPTPSDI VSYSTFPGFVSWRD KSGSWY+ETLD + EQWA SEDL
Sbjct: 359 EGPRTLDQLDAVSSLPTPSDILVSYSTFPGFVSWRDKKSGSWYIETLDGVLEQWARSEDL 418
Query: 381 QSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS 416
QSLLLRVANAVS KG+YKQ+PGCFNFLRKKLFFKTS
Sbjct: 419 QSLLLRVANAVSEKGVYKQIPGCFNFLRKKLFFKTS 454
Score = 349 (127.9 bits), Expect = 5.9e-166, Sum P(2) = 5.9e-166
Identities = 79/134 (58%), Positives = 95/134 (70%)
Query: 1 MDEADXXXXXXXXXXXVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
M+EAD V ELQV +LWDALLSRELF MIEDIQRAGSGSRRDQARQL+I
Sbjct: 1 MEEADRQLLRRCRVRLVRELQVAELWDALLSRELFTRDMIEDIQRAGSGSRRDQARQLVI 60
Query: 61 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPT---LENLTPVVLRP---E 114
DLETRG QALP FISCLEDTGQ LASFL+++ QAAK L++L PVVL P +
Sbjct: 61 DLETRGRQALPRFISCLEDTGQGSLASFLQSSGQAAKQDPEAVTPLDHLVPVVLGPMGLK 120
Query: 115 IRKPEVLRPETPRP 128
++ +V++ + +P
Sbjct: 121 SKEQKVVKLDPSQP 134
^ = trembl|AB015653|AB015653_1 product: "caspase-9 beta"; Homo sapiens mRNA for
caspase-9 beta, complete cds. //:trembl|AF093130|AF093130_1 gene:
"CASP9"; product: "caspase 9 short isoform"; Homo sapiens caspase
9 short isoform (CASP9) mRNA, complete cds.
//:trembl|AX134421|AX134421_1 unnamed ORF; Sequence 17 from Patent
WO0129232. //:gp|AB015653|5103140 caspase-9 beta [Homo
sapiens]//:gp|AX134421|14271068 unnamed protein product [Homo
sapiens]//:gp|AF093130|4218961 caspase 9 short isoform [Homo
sapiens]
Length = 266
0 60 120 180 240
| | | | | |266
trembl|AB015653|AB015 | __________________________________________________
Local hits (HSPs) | __________________________________________________
Score = 677 (243.4 bits), Expect = 1.3e-131, Sum P(2) = 1.3e-131
Identities = 127/127 (100%), Positives = 127/127 (100%)
Query: 290 EQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFP 349
EQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFP
Sbjct: 140 EQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFP 199
Query: 350 GFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRK 409
GFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRK
Sbjct: 200 GFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRK 259
Query: 410 KLFFKTS 416
KLFFKTS
Sbjct: 260 KLFFKTS 266
Score = 637 (229.3 bits), Expect = 1.3e-131, Sum P(2) = 1.3e-131
Identities = 128/139 (92%), Positives = 128/139 (92%)
Query: 1 MDEADXXXXXXXXXXXVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
MDEAD VEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII
Sbjct: 1 MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
Query: 61 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV 120
DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV
Sbjct: 61 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEV 120
Query: 121 LRPETPRPVDIGSGGFGDV 139
LRPETPRPVDIGSGGFGDV
Sbjct: 121 LRPETPRPVDIGSGGFGDV 139
^ = sptrembl|Q90WU0|Q90WU0 Caspase 9 (Fragment).//:trembl|AY057940|AY057940_1
product: "caspase 9"; Gallus gallus caspase 9 mRNA, partial cds.
//:gp|AY057940|16555409 caspase 9 [Gallus gallus]
Length = 403
0 80 160 240 320 400
| | | | | |403
sptrembl|Q90WU0|Q90WU | __________________________________________________
Local hits (HSPs) | _____________________________________________
Score = 986 (352.1 bits), Expect = 4.6e-99, P = 4.6e-99
Identities = 208/371 (56%), Positives = 251/371 (67%)
Query: 52 RDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVL 111
++QARQL+IDLETRG QA P+F+S L DTG LA L + +S P +L PV L
Sbjct: 34 KEQARQLVIDLETRGKQAFPIFLSILRDTGHGDLADMLDEGC-GSPMSPPV--DLRPVQL 90
Query: 112 R-PEIRKPE-VLRPETPR-PVDIGSGGF------GDVGALESLRGNADLAYILSMEPCGH 162
P R+ + V E PV S F A++ R D PCGH
Sbjct: 91 ELPGDRRDKSVSTAERLSIPVQPESERFRMPPAPAQGSAVDKSRPT-DWCTSCEQTPCGH 149
Query: 163 CLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ 222
CLI NNV+F R+S L TR GS+IDCEKL +RF SL F V +L A+++ + L +LA+
Sbjct: 150 CLIFNNVSFSRDSDLSTRAGSDIDCEKLEKRFRSLCFHVRTLRNLKAQEIDVELRKLARL 209
Query: 223 DHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLF 282
DH ALDCC+VVILSHGCQ SH+QFPG +YGTDG + +E+IVN FNG+ CPSL GKPKLF
Sbjct: 210 DHSALDCCLVVILSHGCQTSHIQFPGGIYGTDGKIIPIERIVNYFNGSQCPSLRGKPKLF 269
Query: 283 FIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIF 342
FIQACGGEQKD GFEV SP+DE+ + E DA PFQ D+ DA++SLPTP DI
Sbjct: 270 FIQACGGEQKDQGFEVDCESPQDETCRRSIESDAIPFQAPSGNEDEPDAVASLPTPGDIL 329
Query: 343 VSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPG 402
VSYSTFPGFVSWRD SGSWYVETLD + E +A SEDL + LLRV++ VS KG YKQ+PG
Sbjct: 330 VSYSTFPGFVSWRDKVSGSWYVETLDSVLEHYARSEDLLTKLLRVSDIVSSKGRYKQIPG 389
Query: 403 CFNFLRKKLFF 413
CFNFLRKK+FF
Sbjct: 390 CFNFLRKKIFF 400
^ = sptrembl|Q9IB63|Q9IB63 Caspase-9.//:trembl|AB038172|AB038172_1 gene:
"xCaspase-9"; product: "caspase-9"; Xenopus laevis mRNA for
caspase-9, complete cds. //:gp|AB038172|7619908 caspase-9 [Xenopus
laevis]
Length = 399
0 80 160 240 320
| | | | | |399
sptrembl|Q9IB63|Q9IB6 | __________________________________________________
Local hits (HSPs) | _______________________________________________
Score = 937 (334.9 bits), Expect = 7.2e-94, P = 7.2e-94
Identities = 194/367 (52%), Positives = 250/367 (68%)
Query: 49 GSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTP 108
G+RRDQAR+L+++LETRGSQA PLF+ CL++T Q LA FL+++ ++ +P +P
Sbjct: 47 GTRRDQARKLLVELETRGSQAFPLFLLCLKETAQHDLADFLQSD-SGTRVLQPIPTTPSP 105
Query: 109 VVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINN 168
V L+P P+ E P +I S G L+ D Y +S +P G CLIINN
Sbjct: 106 V-LKP---LPKAEPAEYPAR-EIRSRK----GTLDK-----DKDYPMSSDPIGFCLIINN 151
Query: 169 VNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALD 228
+NF +GL TRTGS+ID +KL R S HF V VK +LT + M L LA QDH D
Sbjct: 152 MNFHECTGLSTRTGSDIDRDKLANRMRSFHFEVTVKDNLTGQAMHDHLQALADQDHSLQD 211
Query: 229 CCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACG 288
CC+VVILSHGC+ H+QFPG VYGTDG + VE+IV+ FNG+ CPSL GKPK+F IQACG
Sbjct: 212 CCLVVILSHGCETRHIQFPGGVYGTDGIRIPVERIVSYFNGSKCPSLRGKPKIFIIQACG 271
Query: 289 GEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTF 348
G+QKD G EV S +P ++ + DATP G D++DA+S++PTPSDI VSYSTF
Sbjct: 272 GDQKDKGCEVTSETPPLSPTSTSLQSDATPVFSGEGDRDEVDAVSNIPTPSDILVSYSTF 331
Query: 349 PGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLR 408
PG+VSWRD +GSWYVE LD + + A ++DLQSLL+ VA+ VS KG YKQ+PG FNFLR
Sbjct: 332 PGYVSWRDKHTGSWYVEVLDSVLAEHAAADDLQSLLVMVADGVSSKGTYKQIPGYFNFLR 391
Query: 409 KKLFFKT 415
K+ +FKT
Sbjct: 392 KRFYFKT 398
Score = 225 (84.3 bits), Expect = 5.7e-16, P = 5.7e-16
Identities = 48/97 (49%), Positives = 69/97 (71%)
Query: 17 VEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISC 76
V+ LQV +LWD L+ R +F MIE+IQR G+RRDQAR+L+++LETRGSQA PLF+ C
Sbjct: 17 VQSLQVKELWDLLVERGVFSNDMIEEIQR--EGTRRDQARKLLVELETRGSQAFPLFLLC 74
Query: 77 LEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRP 113
L++T Q LA FL+++ ++ +P +PV L+P
Sbjct: 75 LKETAQHDLADFLQSD-SGTRVLQPIPTTPSPV-LKP 109
^ = sptrembl|Q99M88|Q99M88 Caspase-9 CTD isoform.//:trembl|AY008275|AY008275_1
product: "caspase-9 CTD isoform"; Rattus norvegicus caspase-9 CTD
isoform mRNA, complete cds. //:gp|AY008275|13569833 caspase-9 CTD
isoform [Rattus norvegicus]
Length = 383
0 80 160 240 320
| | | | | |383
sptrembl|Q99M88|Q99M8 | __________________________________________________
Local hits (HSPs) | ___________________________________________
Score = 738 (264.8 bits), Expect = 8.8e-73, P = 8.8e-73
Identities = 148/209 (70%), Positives = 164/209 (78%)
Query: 89 LRTNRQ-AAKL--SKPTLENLTPVVLRPE----IR-KPEVLRPETPRPVDIGSGGFGDVG 140
L++ Q KL S+P L NLTPVVL PE R +PEVL PETPRPVDIGSG DV
Sbjct: 119 LKSKEQKVVKLDPSQPALGNLTPVVLGPEELWPTRLRPEVLTPETPRPVDIGSGRAHDVC 178
Query: 141 ALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFM 200
+ +AD+AY L +PCGHCLIINNVNFC SGL TR GS++DCEKL+ RF L FM
Sbjct: 179 TPGKIERHADMAYTLDSDPCGHCLIINNVNFCPSSGLSTRIGSHVDCEKLQHRFCWLRFM 238
Query: 201 VEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSV 260
VEVK DLTAKKMV AL+E+A +DH ALDC VVVILSHGCQASHLQFPGAVYGTDGC VS+
Sbjct: 239 VEVKNDLTAKKMVTALMEMAHRDHRALDCFVVVILSHGCQASHLQFPGAVYGTDGCSVSI 298
Query: 261 EKIVNIFNGTSCPSLGGKPKLFFIQACGG 289
E+IVNIFNGT CPSLGGKPKLFFIQACGG
Sbjct: 299 ERIVNIFNGTGCPSLGGKPKLFFIQACGG 327
Score = 349 (127.9 bits), Expect = 1.5e-31, P = 1.5e-31
Identities = 79/134 (58%), Positives = 95/134 (70%)
Query: 1 MDEADXXXXXXXXXXXVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLII 60
M+EAD V ELQV +LWDALLSRELF MIEDIQRAGSGSRRDQARQL+I
Sbjct: 1 MEEADRQLLRRCRVRLVRELQVAELWDALLSRELFTRDMIEDIQRAGSGSRRDQARQLVI 60
Query: 61 DLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPT---LENLTPVVLRP---E 114
DLETRG QALP FISCLEDTGQ LASFL+++ QAAK L++L PVVL P +
Sbjct: 61 DLETRGRQALPRFISCLEDTGQGSLASFLQSSGQAAKQDPEAVTPLDHLVPVVLGPMGLK 120
Query: 115 IRKPEVLRPETPRP 128
++ +V++ + +P
Sbjct: 121 SKEQKVVKLDPSQP 134
^ = trembl|U64963|GGU64963_1 gene: "ich-1"; product: "cysteine protease
caspase-2"; Gallus gallus cysteine protease caspase-2 (ich-1)
mRNA, partial cds. //:gp|U64963|1490878 cysteine protease caspase-2
[Gallus gallus]
Length = 428
0 90 180 270 360
| | | | | |428
trembl|U64963|GGU6496 | __________________________________________________
Local hits (HSPs) | ___________________________________________
Score = 433 (157.5 bits), Expect = 1.8e-40, P = 1.8e-40
Identities = 123/394 (31%), Positives = 191/394 (48%)
Query: 19 ELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLE 78
EL + +L + ++ +++ M+E IQ A SGS L + L RG A F L+
Sbjct: 29 ELVLKELMEHMIEKDIITIEMVEMIQ-AKSGSFSQNVEFLNL-LPKRGPNAFSAFCEALQ 86
Query: 79 DTGQDMLASFLRTNRQAAKLSKPTLE-----NLT-PVVLRPEIRKPEVLRPETPRPVDIG 132
+T Q LA + + + TLE NL P+ ++P ++ +D G
Sbjct: 87 ETKQQHLAEMILKTESSLRHGIATLEQRYGSNLPLPLSESCNSKRPRLI---VEHSLDSG 143
Query: 133 SGG-FGDVGAL--ESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEK 189
G V E R + LAY L EP G LI++N++F E L R+G ++DC
Sbjct: 144 DGPPIPPVKHCTPEFYRDHQHLAYKLISEPRGLALILSNIHFSSEKDLEYRSGGDVDCAS 203
Query: 190 LRRRFSSLHFMVEVKGDLTAKKMVLALLELAQ-QDHGALDCCVVVILSHGCQASHLQFPG 248
L F L + V V D +A++M AL ++ DH +D C+V +LSHG + G
Sbjct: 204 LELLFKHLGYQVTVFHDQSAEEMESALERFSKLPDHQDVDSCIVALLSHGVE-------G 256
Query: 249 AVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESP 308
VYGTDG + +++ +F+ +CP+L KPK+FFIQAC G++ D G + +SP
Sbjct: 257 GVYGTDGKLLQLQEAFRLFDNANCPNLQNKPKMFFIQACRGDETDRGVDQRDGKERSDSP 316
Query: 309 GSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLD 368
G E DA +E L+ LPT SD+ Y+ G + R+ K GSWY+E L
Sbjct: 317 GCE-ESDANK-EENLKL--------RLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALT 366
Query: 369 DIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPG 402
+F + + + +L++V + + Y PG
Sbjct: 367 TVFAEDSRDTHVADMLVKVNRQIKQREGYA--PG 398
^ = swissnew|Q60431|ICE3_CRILO Apopain precursor (EC 3.4.22.-) (Cysteine
protease CPP32) (Yama protein) (CPP-32) (Caspase-3) (CASP-3) (SREBP
cleavage activity 1) (SCA-1).//:swiss|Q60431|ICE3_CRILO Apopain
precursor (EC 3.4.22.-) (Cysteine protease CPP32) (Yama protein)
(CPP-32) (Caspase-3) (CASP-3) (SREBP cleavage activity 1)
(SCA-1).//:trembl|U27463|CG27463_1 gene: "CPP-32"; Cricetinae gen.
sp. CPP-32 mRNA, complete cds. //:gp|U27463|1244444 CPP-32 gene
product [Cricetinae gen. sp.]
Length = 277
0 60 120 180 240
| | | | | |277
swissnew|Q60431|ICE3_ | __________________________________________________
Local hits (HSPs) | __________________________ _______________
Score = 292 (107.8 bits), Expect = 6.0e-39, Sum P(2) = 6.0e-39
Identities = 62/156 (39%), Positives = 92/156 (58%)
Query: 150 DLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTA 209
D +Y + G C+IINN NF + +G+ R+G+++D KLR F +L + V K DLT
Sbjct: 34 DSSYKMDYPEMGVCIIINNKNFHKSTGMTPRSGTDVDAAKLRETFMALKYEVRNKNDLTR 93
Query: 210 KKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNG 269
+++V + +++DH V VILSHG + G ++GTDG P+ ++K+ + F G
Sbjct: 94 EEIVELMKNASKEDHSKRSSFVCVILSHGDE-------GVIFGTDG-PIDLKKLTSYFRG 145
Query: 270 TSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPED 305
C SL GKPKLF IQAC G + D G E S + +D
Sbjct: 146 DYCRSLIGKPKLFIIQACRGTELDCGIETDSGTEDD 181
Score = 143 (55.4 bits), Expect = 6.0e-39, Sum P(2) = 6.0e-39
Identities = 30/89 (33%), Positives = 50/89 (56%)
Query: 335 LPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAV--- 391
+P +D +YST PG+ SWR+PK GSW++++L + + +AH + +L RV V
Sbjct: 187 IPVEADFLYAYSTAPGYYSWRNPKDGSWFIQSLCSMLKLYAHKLEFMHILTRVNRKVATE 246
Query: 392 ----SVKGIY---KQMPGCFNFLRKKLFF 413
S+ + KQ+P + L K+L+F
Sbjct: 247 FESFSLDSTFHAKKQIPCIVSMLTKELYF 275
^ = sptrembl|Q8JGM9|Q8JGM9 Caspase 3-like.//:trembl|AY102865|AY102865_1 gene:
"CASP3"; product: "caspase 3-like"; Takifugu rubripes caspase
3-like (CASP3) mRNA, complete cds. //:gp|AY102865|21392367 caspase
3-like [Takifugu rubripes]
Length = 280
0 60 120 180 240
| | | | | |280
sptrembl|Q8JGM9|Q8JGM | __________________________________________________
Local hits (HSPs) | __________________________________________
Score = 297 (109.6 bits), Expect = 9.7e-39, Sum P(2) = 9.7e-39
Identities = 69/164 (42%), Positives = 91/164 (55%)
Query: 153 YILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKM 212
Y L GHC+IINN NF R +G+ TR G+++D + F SL + V+V D T K+M
Sbjct: 43 YSLDFPNMGHCIIINNKNFDRRTGMNTRNGTDVDAANAMKVFLSLGYKVKVHNDQTVKQM 102
Query: 213 VLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSC 272
L+ A++DH A V V+LSHG + G +GTDG V ++ + ++F G C
Sbjct: 103 KQLLVSAAEEDHSACASFVCVLLSHGDE-------GVFFGTDGS-VELKYLTSLFRGDRC 154
Query: 273 PSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNP-EPD 315
SL GKPKLFFIQAC G D G E S + D S P E D
Sbjct: 155 KSLVGKPKLFFIQACRGNDLDGGIETDSAA--DSSTTKIPVEAD 196
Score = 136 (52.9 bits), Expect = 9.7e-39, Sum P(2) = 9.7e-39
Identities = 32/103 (31%), Positives = 57/103 (55%)
Query: 322 GLRTFDQLDAISS-LPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDL 380
G+ T D+ ++ +P +D ++ST PG+ SWR+ SGSW++++L D ++ +L
Sbjct: 177 GIETDSAADSSTTKIPVEADFLYAFSTAPGYYSWRNTTSGSWFMQSLCDAISKYGKELEL 236
Query: 381 QSLLLRVANAVSVK--------GI--YKQMPGCFNFLRKKLFF 413
Q +L RV + V+V G KQ+P + L K+++F
Sbjct: 237 QHILTRVNHKVAVDFESVSNLPGFDAKKQIPCIVSMLTKEMYF 279
^ = sptrembl|Q8ITP3|Q8ITP3 AmphiCASP-3/7.//:trembl|AF412335|AF412335_1 product:
"amphiCASP-3/7"; Branchiostoma floridae amphiCASP-3/7 mRNA,
complete cds. //:gp|AF412335|24078495 amphiCASP-3/7 [Branchiostoma
floridae]
Length = 328
0 70 140 210 280
| | | | | |328
sptrembl|Q8ITP3|Q8ITP | __________________________________________________
Local hits (HSPs) | _______________________________
Score = 287 (106.1 bits), Expect = 2.6e-38, Sum P(2) = 2.6e-38
Identities = 64/154 (41%), Positives = 91/154 (59%)
Query: 161 GHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELA 220
G +IINN +F + +G+ TR G+++D L R FS L F +V +L +K +L++L+LA
Sbjct: 87 GQAIIINNKDFEKHTGMNTRRGTDLDANNLYRIFSKLGFETKVFDNLPCRK-ILSVLQLA 145
Query: 221 -QQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKP 279
++DH +DC ILSHG + G +YGTDG + V ++ F G CP L GKP
Sbjct: 146 AREDHRDVDCFACAILSHGEE-------GVIYGTDG-HMEVTEVTKPFRGDRCPGLVGKP 197
Query: 280 KLFFIQACGGEQKDHGFEVASTSPE--DESPGSN 311
KLFF+QAC G + DHG ++ PE DE N
Sbjct: 198 KLFFLQACRGNEFDHGVDMPDALPEVQDELDAGN 231
Score = 142 (55.0 bits), Expect = 2.6e-38, Sum P(2) = 2.6e-38
Identities = 31/81 (38%), Positives = 47/81 (58%)
Query: 314 PDATPFQEGLRTFDQLDA--ISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIF 371
PDA P + D+LDA ++LP +D ++YST PG+ SWR+P GSWY++ L +
Sbjct: 217 PDALPEVQ-----DELDAGNKATLPAEADFLLAYSTVPGYYSWRNPGRGSWYIQALCAVL 271
Query: 372 EQWAHSEDLQSLLLRVANAVS 392
E+ ++ LL RV V+
Sbjct: 272 EREGTDLEIMQLLTRVNKLVA 292
^ = sptrembl|Q8CHV5|Q8CHV5 Caspase 3, apoptosis related cysteine protease
(Fragment).//:trembl|BC038825|BC038825_1 product: "caspase 3,
apoptosis related cysteine protease"; Mus musculus, caspase 3,
apoptosis related cysteine protease, clone IMAGE:4482368, mRNA,
partial cds. //:gp|BC038825|24416451 caspase 3, apoptosis related
cysteine protease [Mus musculus]
Length = 313
0 70 140 210 280
| | | | | |313
sptrembl|Q8CHV5|Q8CHV | __________________________________________________
Local hits (HSPs) | ______________________________________
Score = 288 (106.4 bits), Expect = 3.3e-38, Sum P(2) = 3.3e-38
Identities = 63/157 (40%), Positives = 94/157 (59%)
Query: 150 DLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTA 209
D +Y + G C+IINN NF + +G+ +R+G+++D LR F L + V K DLT
Sbjct: 70 DSSYKMDYPEMGICIIINNKNFHKSTGMSSRSGTDVDAANLRETFMGLKYQVRNKNDLT- 128
Query: 210 KKMVLALLE-LAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFN 268
++ +L L++ ++++DH V VILSHG + G +YGT+G PV ++K+ + F
Sbjct: 129 REDILELMDSVSKEDHSKRSSFVCVILSHGDE-------GVIYGTNG-PVELKKLTSFFR 180
Query: 269 GTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPED 305
G C SL GKPKLF IQAC G + D G E S + E+
Sbjct: 181 GDYCRSLTGKPKLFIIQACRGTELDCGIETDSGTDEE 217
Score = 140 (54.3 bits), Expect = 3.3e-38, Sum P(2) = 3.3e-38
Identities = 31/97 (31%), Positives = 52/97 (53%)
Query: 327 DQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLR 386
D+ A +P +D +YST PG+ SWR+ K GSW++++L + + +AH + +L R
Sbjct: 215 DEEMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCSMLKLYAHKLEFMHILTR 274
Query: 387 VANAV-------SVKGIY---KQMPGCFNFLRKKLFF 413
V V S+ + KQ+P + L K+L+F
Sbjct: 275 VNRKVATEFESFSLDSTFHAKKQIPCIVSMLTKELYF 311
^ = sptrembl|Q8MJU1|Q8MJU1 Caspase3.//:trembl|AB090246|AB090246_1 product:
"caspase3"; Felis catus mRNA for caspase3, complete cds.
//:gp|AB090246|22450187 caspase3 [Felis catus]
Length = 277
0 60 120 180 240
| | | | | |277
sptrembl|Q8MJU1|Q8MJU | __________________________________________________
Local hits (HSPs) | ___________________________________________
Score = 288 (106.4 bits), Expect = 5.3e-38, Sum P(2) = 5.3e-38
Identities = 61/156 (39%), Positives = 92/156 (58%)
Query: 150 DLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTA 209
D +Y + G C+IINN NF +G+ +R+G+++D LR F++L + V K DLT
Sbjct: 34 DNSYKMDYPEMGLCIIINNKNFHESTGMPSRSGTDVDAANLRETFTNLKYEVRNKNDLTR 93
Query: 210 KKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNG 269
+++V L ++++DH + V+LSHG + G +YGT+G PV ++K+ F G
Sbjct: 94 EQIVALLDSVSREDHSKRSSFICVLLSHGEE-------GIIYGTNG-PVDLKKLTGFFRG 145
Query: 270 TSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPED 305
C SL GKPKLF IQAC G + D G E S + +D
Sbjct: 146 DYCRSLTGKPKLFIIQACRGTELDCGIETDSGTEDD 181
Score = 138 (53.6 bits), Expect = 5.3e-38, Sum P(2) = 5.3e-38
Identities = 32/99 (32%), Positives = 52/99 (52%)
Query: 325 TFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLL 384
T D + A +P +D +YST PG+ SWR+ K GSW++++L + +AH + +L
Sbjct: 178 TEDDI-ACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCSMLRLYAHELEFMHIL 236
Query: 385 LRVANAV-------SVKGIY---KQMPGCFNFLRKKLFF 413
RV V S+ + KQ+P + L K+L+F
Sbjct: 237 TRVNRKVATEFESFSLDSAFHGKKQIPCIVSMLTKELYF 275
^ = sptrembl|Q95ND5|Q95ND5 Caspase-3.//:trembl|AB029345|AB029345_1 product:
"caspase-3"; Sus scrofa mRNA for caspase-3, complete cds.
//:gp|AB029345|14090240 caspase-3 [Sus scrofa]
Length = 277
0 60 120 180 240
| | | | | |277
sptrembl|Q95ND5|Q95ND | __________________________________________________
Local hits (HSPs) | ___________________________________________
Score = 282 (104.3 bits), Expect = 5.3e-38, Sum P(2) = 5.3e-38
Identities = 57/156 (36%), Positives = 94/156 (60%)
Query: 150 DLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTA 209
D++Y + G C+IINN NF + +G+ R+G+++D LR F++L + V K DLT
Sbjct: 34 DVSYKMDYPEMGLCIIINNKNFDKNTGMACRSGTDVDAANLRETFTNLKYEVRNKNDLTR 93
Query: 210 KKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNG 269
++++ + ++++DH + V+LSHG + G ++GT+G PV ++K+ + F G
Sbjct: 94 EEILELMHSVSKEDHSKRSSFICVLLSHGEE-------GKIFGTNG-PVDLKKLTSFFRG 145
Query: 270 TSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPED 305
C +L GKPKLF IQAC G + D G E S + +D
Sbjct: 146 DCCRTLTGKPKLFIIQACRGTELDCGIETDSGTEDD 181
Score = 144 (55.7 bits), Expect = 5.3e-38, Sum P(2) = 5.3e-38
Identities = 33/99 (33%), Positives = 54/99 (54%)
Query: 325 TFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLL 384
T D + A +P +D +YST PG+ SWR+ K GSW++++L +Q+ H +L +L
Sbjct: 178 TEDDM-ACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAALKQYVHKLELMHIL 236
Query: 385 LRVANAVSVK-------GIY---KQMPGCFNFLRKKLFF 413
RV V+V+ + KQ+P + L K+L+F
Sbjct: 237 TRVNRKVAVEFESFSTDSTFHAKKQIPCIVSMLTKELYF 275
^ = swissnew|P42574|ICE3_HUMAN Apopain precursor (EC 3.4.22.-) (Cysteine
protease CPP32) (Yama protein) (CPP-32) (Caspase-3) (CASP-3) (SREBP
cleavage activity 1) (SCA-1).//:swiss|P42574|ICE3_HUMAN Apopain
precursor (EC 3.4.22.-) (Cysteine protease CPP32) (Yama protein)
(CPP-32) (Caspase-3) (CASP-3) (SREBP cleavage activity 1)
(SCA-1).//:pdb|1CP3|1CP3-A CRYSTAL STRUCTURE OF THE COMPLEX OF
APOPAIN WITH THE TETRAPEPTIDE INHIBITOR ACE-DVAD-FMC
//:trembl|U13737|HS13737_1 product: "cysteine protease CPP32
isoform alpha"; Human cysteine protease CPP32 isoform alpha mRNA,
complete cds. //:trembl|AX134409|AX134409_1 unnamed ORF; Sequence
5 from Patent WO0129232. //:trembl|AX556450|AX556450_1 unnamed ORF;
Sequence 1 from Patent WO0248329. //:pironly|A55315|A55315 cysteine
proteinase (EC 3.4.22.-) CPP32 precursor - human//:gp|U13737|561666
cysteine protease CPP32 isoform alpha [Homo
sapiens]//:gp|AX134409|14271056 unnamed protein product [Homo
sapiens]//:gp|AX556450|25899709 unnamed protein product [Homo
sapiens]
Length = 277
0 60 120 180 240
| | | | | |277
swissnew|P42574|ICE3_ | __________________________________________________
Local hits (HSPs) | ___________________________________________
Score = 292 (107.8 bits), Expect = 6.7e-38, Sum P(2) = 6.7e-38
Identities = 62/156 (39%), Positives = 93/156 (59%)
Query: 150 DLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTA 209
D +Y + G C+IINN NF + +G+ +R+G+++D LR F +L + V K DLT
Sbjct: 34 DNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTR 93
Query: 210 KKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNG 269
+++V + +++++DH V V+LSHG + G ++GT+G PV ++KI N F G
Sbjct: 94 EEIVELMRDVSKEDHSKRSSFVCVLLSHGEE-------GIIFGTNG-PVDLKKITNFFRG 145
Query: 270 TSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPED 305
C SL GKPKLF IQAC G + D G E S +D
Sbjct: 146 DRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDD 181
Score = 133 (51.9 bits), Expect = 6.7e-38, Sum P(2) = 6.7e-38
Identities = 32/105 (30%), Positives = 55/105 (52%)
Query: 322 GLRTFDQLD---AISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSE 378
G+ T +D A +P +D +YST PG+ SWR+ K GSW++++L + +Q+A
Sbjct: 171 GIETDSGVDDDMACHKIPVDADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKL 230
Query: 379 DLQSLLLRVANAVSVK-------GIY---KQMPGCFNFLRKKLFF 413
+ +L RV V+ + + KQ+P + L K+L+F
Sbjct: 231 EFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYF 275
^ = sptrembl|Q8I6Y2|Q8I6Y2 Caspase-3.//:tremblnew|AJ344144|GCY344144_1 gene:
"casp-3l"; product: "caspase-3"; Geodia cydonium mRNA for
caspase-3 (casp-3l gene) //:gp|AJ344144|27526602 caspase-3 [Geodia
cydonium]
Length = 426
0 90 180 270 360
| | | | | |426
sptrembl|Q8I6Y2|Q8I6Y | __________________________________________________
Local hits (HSPs) | __________________________________________
Score = 405 (147.6 bits), Expect = 1.7e-37, P = 1.7e-37
Identities = 121/378 (32%), Positives = 175/378 (46%)
Query: 53 DQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLR 112
+ A +L+ L R S L + + CL + Q+ A ++ R KP P
Sbjct: 54 EAADELMKALRRRDSSVLDILVECLAEQ-QEANADLIKKIRSFFP-EKPR-----PPPPP 106
Query: 113 PEIRKPEVLR-PETPRPVDIGSGGFGDVGAL--ESLRGNADLAYILSMEPCGHCLIINNV 169
P I V R + P P+ + + E AY +S P G LIINN
Sbjct: 107 PTIDSTPVTRYDDWPAPIAPTATSHPPIPPPPEEGTDAGRKDAYKMSSRPRGMALIINNR 166
Query: 170 NFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDC 229
NF G++ R G++ D E L F+ L K +LT K M +LA++DH A DC
Sbjct: 167 NFT--CGMKERVGTDKDAENLYGLFNWLGMATIRKDNLTGKAMTREFEDLARRDHSAYDC 224
Query: 230 CVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGG 289
VV IL+HG G +Y TDG + VE + F+G + PSL GKPK+F +QAC G
Sbjct: 225 VVVAILTHGIS-------GRLYSTDGDLIPVEDLTKYFDGVNRPSLIGKPKVFVVQACRG 277
Query: 290 EQKDHGFEVASTSPEDESPGSNPEPDATPFQ-----EGLRTFDQLD----AISSLPTPSD 340
+ D+G E ST E ES + Q E D+ D + +LPT +D
Sbjct: 278 GKFDYGVESESTDGEGESVNKETANEMMEKQFDKVVEKALDADETDGGGYSREALPTEAD 337
Query: 341 IFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSV----KGI 396
++Y+T PG+VSWR+ + GSW+++ D A E +L V V+ +G
Sbjct: 338 FVLAYATVPGYVSWRNSEYGSWFIKAFVDTMRDLASKEHFMDILTEVNRKVAYDFQSRGR 397
Query: 397 YKQMPGCFNFLRKKLFFK 414
KQ+P L +KL+F+
Sbjct: 398 NKQIPAPVTMLTRKLYFR 415
^ = swissnew|P55213|ICE3_RAT Apopain precursor (EC 3.4.22.-) (Cysteine protease
CPP32) (Yama protein) (CPP-32) (Caspase-3) (CASP-3) (SREBP cleavage
activity 1) (SCA-1) (LICE) (IRP).//:swiss|P55213|ICE3_RAT Apopain
precursor (EC 3.4.22.-) (Cysteine protease CPP32) (Yama protein)
(CPP-32) (Caspase-3) (CASP-3) (SREBP cleavage activity 1) (SCA-1)
(LICE) (IRP).//:trembl|U49930|RNU49930_1 gene: "Lice"; product:
"ICE-like cysteine protease"; Rattus norvegicus ICE-like cysteine
protease (Lice) mRNA, complete cds. //:gp|U49930|1518936 ICE-like
cysteine protease [Rattus norvegicus]
Length = 277
0 60 120 180 240
| | | | | |277
swissnew|P55213|ICE3_ | __________________________________________________
Local hits (HSPs) | ___________________________________________
Score = 283 (104.7 bits), Expect = 4.7e-37, Sum P(2) = 4.7e-37
Identities = 60/156 (38%), Positives = 91/156 (58%)
Query: 150 DLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTA 209
D +Y + G C+IINN NF + +G+ R G+++D LR F +L + V K DLT
Sbjct: 34 DSSYKMDYPEMGLCIIINNKNFHKSTGMSARNGTDVDAANLRETFMALKYEVRNKNDLTR 93
Query: 210 KKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNG 269
++++ + ++++DH V VILSHG + G ++GT+G PV ++K+ + F G
Sbjct: 94 EEIMELMDSVSKEDHSKRSSFVCVILSHGDE-------GVIFGTNG-PVDLKKLTSFFRG 145
Query: 270 TSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPED 305
C SL GKPKLF IQAC G + D G E S + +D
Sbjct: 146 DYCRSLTGKPKLFIIQACRGTELDCGIETDSGTDDD 181
Score = 134 (52.2 bits), Expect = 4.7e-37, Sum P(2) = 4.7e-37
Identities = 31/99 (31%), Positives = 53/99 (53%)
Query: 325 TFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLL 384
T D + A +P +D +YST PG+ SWR+ + GSW++++L + + +AH + +L
Sbjct: 178 TDDDM-ACQKIPVEADFLYAYSTAPGYYSWRNSRDGSWFIQSLCAMLKLYAHKLEFMHIL 236
Query: 385 LRVANAV-------SVKGIY---KQMPGCFNFLRKKLFF 413
RV V S+ + KQ+P + L K+L+F
Sbjct: 237 TRVNRKVATEFESFSLDATFHAKKQIPCIVSMLTKELYF 275
^ = sptrembl|Q8MJC3|Q8MJC3 Cysteine protease CPP32.//:trembl|AF506008|AF506008_1
product: "cysteine protease CPP32"; Oryctolagus cuniculus cysteine
protease CPP32 mRNA, complete cds. //:gp|AF506008|21321429 cysteine
protease CPP32 [Oryctolagus cuniculus]
Length = 277
0 60 120 180 240
| | | | | |277
sptrembl|Q8MJC3|Q8MJC | __________________________________________________
Local hits (HSPs) | ___________________________________________
Score = 273 (101.2 bits), Expect = 7.8e-37, Sum P(2) = 7.8e-37
Identities = 56/151 (37%), Positives = 89/151 (58%)
Query: 150 DLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTA 209
D +Y + G C+IINN NF + +G+ +R+G++++ L F +L + V K DLT
Sbjct: 34 DNSYKMDYPEMGLCIIINNKNFHKNTGMSSRSGTDVNAANLGETFMNLKYEVRNKNDLTR 93
Query: 210 KKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNG 269
++++ + ++++DH + VILSHG + G +YGT+G P+ ++K+ + F G
Sbjct: 94 EEIMELMYNVSKEDHSKRSSFICVILSHGDE-------GVIYGTNG-PIELKKLTSFFRG 145
Query: 270 TSCPSLGGKPKLFFIQACGGEQKDHGFEVAS 300
C SL GKPKLF IQAC G + D G E S
Sbjct: 146 DYCRSLTGKPKLFIIQACRGTELDSGIETDS 176
Score = 142 (55.0 bits), Expect = 7.8e-37, Sum P(2) = 7.8e-37
Identities = 33/110 (30%), Positives = 57/110 (51%)
Query: 317 TPFQEGLRTFDQLD---AISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQ 373
T G+ T +D A +P +D +YST PG+ SWR+ + GSW++++L + ++
Sbjct: 166 TELDSGIETDSGVDYDMACQKIPVEADFLYAYSTAPGYYSWRNSEEGSWFIQSLCAMLKE 225
Query: 374 WAHSEDLQSLLLRVANAV-------SVKGIY---KQMPGCFNFLRKKLFF 413
+AH + +L RV V S+ + KQ+P + L K+L+F
Sbjct: 226 YAHKLEFMHILTRVNRKVATEFESYSLDATFHAKKQIPCIVSMLTKELYF 275
^ = sptrembl|Q9IB67|Q9IB67 Caspase-2.//:trembl|AB038168|AB038168_1 gene:
"xCaspase-2"; product: "caspase-2"; Xenopus laevis mRNA for
caspase-2, complete cds. //:gp|AB038168|7619900 caspase-2 [Xenopus
laevis]
Length = 423
0 90 180 270 360
| | | | | |423
sptrembl|Q9IB67|Q9IB6 | __________________________________________________
Local hits (HSPs) | ___________________________________________
Score = 397 (144.8 bits), Expect = 1.2e-36, P = 1.2e-36
Identities = 125/393 (31%), Positives = 190/393 (48%)
Query: 19 ELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLE 78
E+ +++L D L+S E+ +M +I S ++ A L+ L RG +A F + L
Sbjct: 23 EMIIEELLDHLVSSEILTNNMHSNIMAYRSDYAQNVA--LLNLLPKRGPRAFSAFCNALH 80
Query: 79 DTGQDMLASFLRTNR--QAAKLSKPTLENLTPV-VLRPEIRKP--EVLRPETPRPVDIGS 133
T Q+ LA + Q ++ P+ V + +P ++ R +D G
Sbjct: 81 STNQEHLAQQVEKEALLQEEFITSKVHHGSFPLPVQESTLSRPGRQICREYREESIDDGD 140
Query: 134 GGFG-DVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRR 192
G + ++ + AY + P G L+I+NV F L R G +D L +
Sbjct: 141 GPVTVQLCSVNFYITHCQQAYKMHSCPRGRALLISNVKF-ETPDLDYRCGGEVDLASLEK 199
Query: 193 RFSSLHFMVEVKGDLTAKKMVLALLEL-AQQDHGALDCCVVVILSHGCQASHLQFPGAVY 251
FSSL + V+V+ +L A+ M+ L A H ALD CVV ILSHG GAVY
Sbjct: 200 LFSSLGYQVDVRCNLNAQSMMSQLGAFSALPVHSALDSCVVAILSHGLD-------GAVY 252
Query: 252 GTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSN 311
GTDG V ++++ + CP L KPK+FFIQAC GE+ D G + + SPG
Sbjct: 253 GTDGKLVQLQEVFTALDNAHCPQLQNKPKMFFIQACRGEETDRGVDQRDGREQSGSPGCE 312
Query: 312 PEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIF 371
+ DA +E ++ LPT SD+ +Y+ G VS R+ K GSW+V+ L +F
Sbjct: 313 -QSDAG--REDIKV--------RLPTQSDMICAYACLKGTVSLRNTKRGSWFVQDLVSVF 361
Query: 372 EQWAHSED--LQSLLLRVANAVSVKGIYKQMPG 402
Q HS+D + +L++V NA+ +K PG
Sbjct: 362 SQ--HSKDTHVADMLVKV-NAL-IKEREGHAPG 390
^ = sptrembl|Q9JHX4|Q9JHX4 Caspase-8.//:trembl|AF279308|AF279308_1 gene:
"CASP8"; product: "caspase-8"; Rattus norvegicus caspase-8 (CASP8)
mRNA, complete cds. //:trembl|AF288372|AF288372_1 product:
"caspase-8"; Rattus norvegicus caspase-8 mRNA, complete cds.
//:gp|AF279308|9454380 caspase-8 [Rattus
norvegicus]//:gp|AF288372|15077072 caspase-8 [Rattus norvegicus]
Length = 482
0 100 200 300 400
| | | | | |482
sptrembl|Q9JHX4|Q9JHX | __________________________________________________
Local hits (HSPs) | ___________________________
Score = 393 (143.4 bits), Expect = 3.2e-36, P = 3.2e-36
Identities = 108/287 (37%), Positives = 146/287 (50%)
Query: 140 GALESLRGNADLAYILSMEPCGHCLIINNVNF--CRE-----SGLRTRTGSNIDCEKLRR 192
G ES N+D Y + +P G+CLI NN NF RE S +R R G+N D E L +
Sbjct: 215 GEQESESLNSDNVYQMKSKPRGYCLIFNNNNFSKAREDIPKLSNMRDRKGTNYDEEALSK 274
Query: 193 RFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYG 252
F LHF + D TA ++ L+ +DH DC + ILSHG + G VYG
Sbjct: 275 TFKELHFEIVSFSDCTASQIHEVLVSYQSKDHKGKDCFICCILSHGDK-------GIVYG 327
Query: 253 TDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNP 312
TDG S+ ++ + F G+ CPSL GKPK+FFIQAC G + F+ A P
Sbjct: 328 TDGKEASIYELTSYFTGSKCPSLAGKPKIFFIQACQG----NNFQKAV-----------P 372
Query: 313 EPDATPF-QEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL-DDI 370
PD T QE + D + +P +D + +T VS+RDP G+WY+++L +
Sbjct: 373 VPDETGLEQEHVLEEDSSSYKNYIPDEADFLLGMATVKNCVSYRDPTRGTWYIQSLCQSL 432
Query: 371 FEQWAHSEDLQSLLLRVANAVSVK----GIYKQMPGCFNFLRKKLFF 413
E+ ED+ S+L V VS K + KQMP LRKKLFF
Sbjct: 433 RERCPRGEDILSILTGVNYDVSNKDNPRNMGKQMPQPIFTLRKKLFF 479
^ = sptrembl|Q8MKI5|Q8MKI5 Caspase-3.//:trembl|AB085580|AB085580_1 product:
"caspase-3"; Canis familiaris mRNA for caspase-3, complete cds.
//:gp|AB085580|20975412 caspase-3 [Canis familiaris]
Length = 277
0 60 120 180 240
| | | | | |277
sptrembl|Q8MKI5|Q8MKI | __________________________________________________
Local hits (HSPs) | _____________________________________
Score = 279 (103.3 bits), Expect = 3.2e-36, Sum P(2) = 3.2e-36
Identities = 59/156 (37%), Positives = 90/156 (57%)
Query: 150 DLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTA 209
D +Y + G C+IINN NF + +G+ R+G+++D LR F++L + V K DLT
Sbjct: 34 DNSYKMDYPEMGLCIIINNKNFHKSTGMAPRSGTDVDAANLRETFTNLKYEVRNKNDLTC 93
Query: 210 KKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNG 269
++++ + ++++DH V V+LSHG + G ++GT+G PV + K+ F G
Sbjct: 94 EEILELMNSVSKEDHSKRSSFVCVLLSHGDE-------GIIFGTNG-PVDLRKVTGFFRG 145
Query: 270 TSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPED 305
C SL GKPKLF IQAC G + D G E S +D
Sbjct: 146 DYCRSLTGKPKLFIIQACRGTELDCGIETDSGIEDD 181
Score = 130 (50.8 bits), Expect = 3.2e-36, Sum P(2) = 3.2e-36
Identities = 22/64 (34%), Positives = 38/64 (59%)
Query: 331 AISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANA 390
A +P +D +YST PG+ SWR+ K GSW++++L + + +AH + +L RV
Sbjct: 183 ACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKLYAHKLEFMHILTRVNRK 242
Query: 391 VSVK 394
V+ +
Sbjct: 243 VATE 246
^ = sptrembl|Q8K241|Q8K241 Caspase 2.//:trembl|BC034262|BC034262_1 product:
"caspase 2"; Mus musculus, caspase 2, clone MGC:25295
IMAGE:4460089, mRNA, complete cds. //:trembl|Y13085|MMCASP2_1
product: "caspase-2"; M.musculus mRNA for caspase-2
//:trembl|D28492|MMNEDD_1 gene: "Nedd2"; product: "caspase-2"; Mus
musculus mRNA for caspase-2, complete cds. //:gp|D28492|3090430
caspase-2 [Mus musculus]//:gp|Y13085|2094808 caspase-2 [Mus
musculus]//:gp|BC034262|21706481 caspase 2 [Mus musculus]
Length = 452
0 90 180 270 360 450
| | | | | |452
sptrembl|Q8K241|Q8K24 | __________________________________________________
Local hits (HSPs) | _________________________________________
Score = 389 (142.0 bits), Expect = 8.4e-36, P = 8.4e-36
Identities = 125/396 (31%), Positives = 185/396 (46%)
Query: 18 EELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCL 77
++L + +L + LL +++ M E IQ G GS Q +L+ L RG QA F L
Sbjct: 49 KQLLLSELLEHLLEKDIITLEMRELIQAKG-GSF-SQNVELLNLLPKRGPQAFDAFCEAL 106
Query: 78 EDTGQDMLASFLRTNRQAAKLSKPTLE-----NLTPVVLR--PEIRKPEVLRPETPRPVD 130
+T Q L L T + P L +L V P ++ + T +D
Sbjct: 107 RETRQGHLEDLLLTTLSDIQHVLPPLSCDYDTSLPFSVCESCPPHKQLRLSTDATEHSLD 166
Query: 131 IGSGG---FGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDC 187
G G E + + LAY L +P G L+++NV+F E L R+G ++D
Sbjct: 167 NGDGPPCLLVKPCTPEFYQAHYQLAYRLQSQPRGLALVLSNVHFTGEKDLEFRSGGDVDH 226
Query: 188 EKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQD-HGALDCCVVVILSHGCQASHLQF 246
L F L + V V D TA++M L AQ H D CVV +LSHG +
Sbjct: 227 TTLVTLFKLLGYNVHVLHDQTAQEMQEKLQNFAQLPAHRVTDSCVVALLSHGVE------ 280
Query: 247 PGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDE 306
G +YG DG + ++++ +F+ +CPSL KPK+FFIQAC G++ D G + +
Sbjct: 281 -GGIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHTQ 339
Query: 307 SPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVET 366
SPG E DA +E L LPT SD+ Y+ G + R+ K GSWY+E
Sbjct: 340 SPGCE-ESDAG--KEELMKM-------RLPTRSDMICGYACLKGNAAMRNTKRGSWYIEA 389
Query: 367 LDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPG 402
L +F + A + +L++V NA+ +K PG
Sbjct: 390 LTQVFSERACDMHVADMLVKV-NAL-IKEREGYAPG 423
^ = sptrembl|O93417|O93417 Caspase-3.//:trembl|AF083029|AF083029_1 product:
"caspase-3"; Gallus gallus caspase-3 mRNA, complete cds.
//:gp|AF083029|3450875 caspase-3 [Gallus gallus]
Length = 283
0 60 120 180 240
| | | | | |283
sptrembl|O93417|O9341 | __________________________________________________
Local hits (HSPs) | _________________________ _______________
Score = 285 (105.4 bits), Expect = 8.4e-36, Sum P(2) = 8.4e-36
Identities = 60/156 (38%), Positives = 93/156 (59%)
Query: 150 DLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTA 209
D +Y + G C+IINN NF R++GL +R+G++ D +R F L + V++ DL++
Sbjct: 42 DDSYRMDYPEIGVCVIINNKNFHRDTGLSSRSGTDADAASVREVFMKLGYKVKLNNDLSS 101
Query: 210 KKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNG 269
+ + L ++++DH V V+LSHG + G YGTDG P+ ++ + ++F G
Sbjct: 102 RDIFKLLKNVSEEDHSKRSSFVCVLLSHGDE-------GLFYGTDG-PLELKVLTSLFRG 153
Query: 270 TSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPED 305
C SL GKPKLFFIQAC G + D G E A + P++
Sbjct: 154 DKCRSLAGKPKLFFIQACRGTELDSGIE-ADSGPDE 188
Score = 120 (47.3 bits), Expect = 8.4e-36, Sum P(2) = 8.4e-36
Identities = 27/88 (30%), Positives = 47/88 (53%)
Query: 335 LPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAV--- 391
+P +D +YST PG+ SWR+ GSW++++L + ++ A +L +L RV V
Sbjct: 194 IPVEADFLYAYSTAPGYYSWRNAAEGSWFIQSLCRMLKEHARKLELMQILTRVNRRVAEY 253
Query: 392 ---SVKGIY---KQMPGCFNFLRKKLFF 413
S + + KQ+P + L K+ +F
Sbjct: 254 ESCSTRQDFNAKKQIPCIVSMLTKEFYF 281
^ = tremblnew|AB090853|AB090853_1 product: "zebrafish caspase-3 His-tag linked";
Synthetic construct genes for zebrafish caspase-3 His-tag linked,
green fluorescent protein, complete cds. //:gpnew|AB090853|28569921
zebrafish caspase-3 His-tag linked [synthetic construct]
Length = 288
0 60 120 180 240
| | | | | |288
tremblnew|AB090853|AB | __________________________________________________
Local hits (HSPs) | _________________________________________
Score = 280 (103.6 bits), Expect = 1.7e-35, Sum P(2) = 1.7e-35
Identities = 63/167 (37%), Positives = 87/167 (52%)
Query: 153 YILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKM 212
Y L+ GHC+IINN NF R +G+ R G+++D + F L ++V+V D T ++
Sbjct: 40 YSLNYPNIGHCIIINNKNFDRRTGMNPRNGTDVDAGNVMNVFRKLGYIVKVYNDQTVAQI 99
Query: 213 VLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSC 272
+ L +A DH V V+LSHG + G +GTD V ++ + ++F G C
Sbjct: 100 MQVLTTVAHDDHSRCASLVCVLLSHGDE-------GVFFGTD-TSVDLKSLTSLFRGDRC 151
Query: 273 PSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPF 319
PSL GKPKLFFIQAC G + D G E T D G P F
Sbjct: 152 PSLVGKPKLFFIQACRGTELDPGVETDHTDHPDIPDGRERIPVEADF 198
Score = 122 (48.0 bits), Expect = 1.7e-35, Sum P(2) = 1.7e-35
Identities = 26/94 (27%), Positives = 51/94 (54%)
Query: 330 DAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVAN 389
D +P +D +YST PG+ SWR+ +GSW++++L ++ ++ +L ++ RV +
Sbjct: 187 DGRERIPVEADFLYAYSTVPGYYSWRNTMTGSWFIQSLCEMMTKYGSELELLQIMTRVNH 246
Query: 390 AVSVK--------GI--YKQMPGCFNFLRKKLFF 413
V++ G KQ+P + L K+++F
Sbjct: 247 KVALDFESTSNMPGFDAKKQIPCIVSMLTKEMYF 280
^ = sptrembl|Q8JIS9|Q8JIS9 Caspase 3B.//:trembl|AB032608|AB032608_1 product:
"caspase 3B"; Oryzias latipes mRNA for caspase 3B, complete cds.
//:gp|AB032608|21623671 caspase 3B [Oryzias latipes]
Length = 280
0 60 120 180 240
| | | | | |280
sptrembl|Q8JIS9|Q8JIS | __________________________________________________
Local hits (HSPs) | _________________________________________
Score = 267 (99.0 bits), Expect = 7.6e-35, Sum P(2) = 7.6e-35
Identities = 58/156 (37%), Positives = 86/156 (55%)
Query: 153 YILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKM 212
Y L+ G C+IINN NF R +G+ R G++ID + FS L + V++ D T K++
Sbjct: 44 YSLNFPTIGLCIIINNKNFDRGTGMNQRNGTDIDAASAMKVFSKLGYRVKIYNDQTVKQI 103
Query: 213 VLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSC 272
L ++++ DH V ++LSHG + G +GTDG + ++ + ++F G C
Sbjct: 104 KQLLTDVSRMDHSDSASFVCILLSHGDE-------GVFFGTDGS-IELKTLTSLFRGDHC 155
Query: 273 PSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESP 308
SL GKPKLFFIQAC G + D G E S + P
Sbjct: 156 KSLVGKPKLFFIQACRGTELDDGIEADSKEDTTKIP 191
Score = 131 (51.2 bits), Expect = 7.6e-35, Sum P(2) = 7.6e-35
Identities = 28/107 (26%), Positives = 58/107 (54%)
Query: 317 TPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAH 376
T +G+ D + + +P +D ++ST PG+ SWR+ +GSW++ +L ++ ++
Sbjct: 173 TELDDGIEA-DSKEDTTKIPVEADFLYAFSTAPGYYSWRNTMTGSWFINSLCEMLSKYGK 231
Query: 377 SEDLQSLLLRVANAVSVK--------GIY--KQMPGCFNFLRKKLFF 413
+L ++ RV + V+V+ G + KQ+P + L K+++F
Sbjct: 232 ELELLHIMTRVNHMVAVEFESISTLPGFHAKKQIPCIVSMLTKEMYF 278
^ = swissnew|P42573|CED3_CAEEL Cell death protein 3 precursor (EC
3.4.22.-).//:swiss|P42573|CED3_CAEEL Cell death protein 3 precursor
(EC 3.4.22.-).//:tremblnew|Z81049|CEC48D1_2 gene: "ced-3"; product:
"C. elegans CED-3 protein (corresponding sequence C48D1.2)";
Caenorhabditis elegans cosmid C48D1 //:trembl|AF210702|AF210702_1
gene: "ced-3"; product: "caspase CED-3"; Caenorhabditis elegans
caspase CED-3 (ced-3) mRNA, complete cds.
//:trembl|Z81049|CEC48D1_3 gene: "ced-3"; product: "C. elegans
ced-3 protein (corresponding sequence C48D1.2)"; Caenorhabditis
elegans cosmid C48D1 //:trembl|L29052|CECED3A_1 gene: "ced-3";
product: "cell death protein"; Caenorhabditis elegans cell death
protein (ced-3) gene, complete cds. //:pironly|A49429|A49429
interleukin-1 beta-converting enzyme homolog CED-3 - Caenorhabditis
elegans//:gp|L29052|6503233 cell death protein [Caenorhabditis
elegans]//:gp|AF210702|11967321 caspase CED-3 [Caenorhabditis
elegans]//:gp|Z81049|15718157 C. elegans CED-3 protein
(corresponding sequence C48D1.2) [Caenorhabditis
elegans]//:worm|CE29088|C48D1.2 locus:ced-3 Caspase recruitment
domain, ICE-like protease (caspase) p20 domain., ICE-like protease
(caspase) p10 domain. status:Confirmed SW:P42573
protein_id:CAB61001.2
Length = 503
0 100 200 300 400 500
| | | | | |503
swissnew|P42573|CED3_ | __________________________________________________
Local hits (HSPs) | ______ _________________________
Score = 323 (118.8 bits), Expect = 1.7e-34, Sum P(2) = 1.7e-34
Identities = 86/268 (32%), Positives = 135/268 (50%)
Query: 159 PCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLE 218
P G CLIINN +F + TR G+ D + L F + + V K +LT + M+L + +
Sbjct: 241 PRGMCLIINNEHF---EQMPTRNGTKADKDNLTNLFRCMGYTVICKDNLTGRGMLLTIRD 297
Query: 219 LAQQD-HGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGG 277
A+ + HG D ++VILSHG + + G D P+S +I ++ N + P L
Sbjct: 298 FAKHESHG--DSAILVILSHGEE-------NVIIGVDDIPISTHEIYDLLNAANAPRLAN 348
Query: 278 KPKLFFIQACGGEQKDHGFEVASTS---PEDESPG-SNPEPDATPFQEGLRTFDQLDAI- 332
KPK+ F+QAC GE++D+GF V + P G N + F +R Q+ +
Sbjct: 349 KPKIVFVQACRGERRDNGFPVLDSVDGVPAFLRRGWDNRDGPLFNFLGCVRP--QVQQVW 406
Query: 333 SSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVS 392
P+ +DI ++Y+T +VSWR+ GSW+++ + ++F A D+ LL V V+
Sbjct: 407 RKKPSQADILIAYATTAQYVSWRNSARGSWFIQAVCEVFSTHAKDMDVVELLTEVNKKVA 466
Query: 393 V-------KGIYKQMPGCFNFLRKKLFF 413
I KQMP + L KK +F
Sbjct: 467 CGFQTSQGSNILKQMPEMTSRLLKKFYF 494
Score = 75 (31.5 bits), Expect = 1.7e-34, Sum P(2) = 1.7e-34
Identities = 18/70 (25%), Positives = 37/70 (52%)
Query: 20 LQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLED 79
L+VD++ + L+++++ + I G+ R++ R+++ ++ RG A F L
Sbjct: 21 LKVDEILEVLIAKQVLNSDNGDMINSCGTV--REKRREIVKAVQRRGDVAFDAFYDALRS 78
Query: 80 TGQDMLASFL 89
TG + LA L
Sbjct: 79 TGHEGLAEVL 88
^ = sptrembl|Q8JIS8|Q8JIS8 Caspase 3A.//:trembl|AB032609|AB032609_1 product:
"caspase 3A"; Oryzias latipes mRNA for caspase 3A, complete cds.
//:gp|AB032609|21623673 caspase 3A [Oryzias latipes]
Length = 290
0 60 120 180 240
| | | | | |290
sptrembl|Q8JIS8|Q8JIS | __________________________________________________
Local hits (HSPs) | ________________________________________
Score = 261 (96.9 bits), Expect = 2.8e-34, Sum P(2) = 2.8e-34
Identities = 59/145 (40%), Positives = 78/145 (53%)
Query: 153 YILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKM 212
Y + G CLIINN NF ++SG+ R G++ D + F L + +++ D T +M
Sbjct: 50 YSMDYPKMGICLIINNKNFHKDSGMGPRNGTDNDAAAAWKSFMKLGYEIQMYNDQTVDQM 109
Query: 213 VLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSC 272
+++ QDH VILSHG + G +YGTDG PVS K++ G SC
Sbjct: 110 KKLFRQMSNQDHSKFASFACVILSHGEE-------GVIYGTDG-PVSFNKLIECLKGRSC 161
Query: 273 PSLGGKPKLFFIQACGGEQKDHGFE 297
SL GKPKLFFIQAC G D G E
Sbjct: 162 LSLVGKPKLFFIQACRGMLFDEGIE 186
Score = 133 (51.9 bits), Expect = 2.8e-34, Sum P(2) = 2.8e-34
Identities = 31/106 (29%), Positives = 54/106 (50%)
Query: 319 FQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSE 378
F EG+ + D +P +D +YST G+ SWR +GSW++++L ++ E+++ +
Sbjct: 181 FDEGIEHDAKDDTSEKIPLEADFLFAYSTVSGYYSWRSTANGSWFIQSLCEMLEKFSKTL 240
Query: 379 DLQSLLLRV-----------ANAVSVKGIYKQMPGCFNFLRKKLFF 413
DL ++ RV +NA G KQ+P + L K +F
Sbjct: 241 DLMQIMTRVNHKVATHFESSSNAPGFSG-KKQIPCIVSMLTKDFYF 285
^ = sptrembl|Q90WU1|Q90WU1 Caspase 8.//:trembl|AY057939|AY057939_1 product:
"caspase 8"; Gallus gallus caspase 8 mRNA, complete cds.
//:gp|AY057939|16555407 caspase 8 [Gallus gallus]
Length = 482
0 100 200 300 400
| | | | | |482
sptrembl|Q90WU1|Q90WU | __________________________________________________
Local hits (HSPs) | ___________ ______________________________
Score = 349 (127.9 bits), Expect = 5.1e-34, Sum P(2) = 5.1e-34
Identities = 109/317 (34%), Positives = 155/317 (48%)
Query: 114 EIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLA-----YILSMEPCGHCLIINN 168
E+ E R T P D V A +SL GN D + Y ++ P G CLI+NN
Sbjct: 187 EMLVTEGQRSSTGAPEDSAIWLASSV-APDSL-GNCDQSSQLEVYKMTSRPRGVCLILNN 244
Query: 169 VNFC--RES-----GLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQ 221
NF RE+ ++ R G+++D + LR+ FS+LHF V D TA+++ +
Sbjct: 245 HNFAKAREAVPELRRMKDRNGTHVDADALRKVFSNLHFTVAEYKDCTAEEIRNIVNNYRC 304
Query: 222 QDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKL 281
DH DC V ILSHG + +YG DG V ++++ F G +C SL GKPK+
Sbjct: 305 MDHNNKDCFVCCILSHGKK-------DIIYGVDGQEVPIQELTTSFTGQNCQSLAGKPKV 357
Query: 282 FFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDI 341
FF+QAC G+ G + + S E + + E DA F QLD I P+ +D
Sbjct: 358 FFVQACQGDAYQKGVTIETDSGEQDY---SLETDAR--------F-QLDCI---PSEADF 402
Query: 342 FVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWA-HSEDLQSLLLRVANAVSVK----GI 396
+ +T +VS+R P G+WY+++L E ED+ ++L V VS K
Sbjct: 403 LLGMTTLQDYVSYRSPSQGTWYIQSLCQHLESSCPRGEDILTILTAVNQEVSSKIDKQNA 462
Query: 397 YKQMPGCFNFLRKKLFF 413
KQMP LRKKL F
Sbjct: 463 GKQMPQPSFTLRKKLIF 479
Score = 39 (18.8 bits), Expect = 5.1e-34, Sum P(2) = 5.1e-34
Identities = 24/110 (21%), Positives = 47/110 (42%)
Query: 17 VEELQVDQLWDALLSREL-FRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFIS 75
++E + ++ D +EL +R + I+ + SR + R+L + R S L
Sbjct: 48 LQEKGMIEVGDLFFLKELLYRINRIDLLASYLGSSREEMERELQVPGRARVSPFRYLLFQ 107
Query: 76 CLEDTGQDMLASF-LRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPE 124
E+ +D + F ++ K K + E P V E+ K +L+ +
Sbjct: 108 LSENITKDDMKCFKFLLGKELPKC-KLSPETTMPDVFI-EMEKKGILKED 155
^ = sptrembl|O77623|O77623 Caspase-3 (Fragment).//:trembl|AF068837|AF068837_1
product: "caspase-3"; Ovis aries caspase-3 mRNA, partial cds.
//:gp|AF068837|3293438 caspase-3 [Ovis aries]
Length = 182
0 40 80 120 160
| | | | | |182
sptrembl|O77623|O7762 | __________________________________________________
Local hits (HSPs) | _______________________________________________
Score = 299 (110.3 bits), Expect = 4.5e-33, Sum P(2) = 4.5e-33
Identities = 61/154 (39%), Positives = 93/154 (60%)
Query: 152 AYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKK 211
+Y + G C+IINN NF +G+ R+G+++D LR F+SL + V +K DLT K+
Sbjct: 5 SYKMDYPEMGLCIIINNKNFHENTGMACRSGTDVDAANLRETFTSLKYEVRIKNDLTRKE 64
Query: 212 MVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTS 271
M+ + +++++DH + V+LSHG + G ++GT+G PV ++K+ + F G
Sbjct: 65 MLELMSDVSKEDHSKRSSFICVLLSHGEE-------GIIFGTNG-PVDLKKLASFFRGDC 116
Query: 272 CPSLGGKPKLFFIQACGGEQKDHGFEVASTSPED 305
C SL GKPKLF IQAC G + D G E S S +D
Sbjct: 117 CRSLTGKPKLFIIQACRGTELDCGIETDSGSEDD 150
Score = 80 (33.2 bits), Expect = 4.5e-33, Sum P(2) = 4.5e-33
Identities = 14/31 (45%), Positives = 19/31 (61%)
Query: 331 AISSLPTPSDIFVSYSTFPGFVSWRDPKSGS 361
A +P +D +YST PG+ SWR+ K GS
Sbjct: 152 ACQKIPVEADFLYAYSTAPGYFSWRNSKYGS 182
^ = swissnew|P45436|CED3_CAEVU Cell death protein 3 precursor (EC
3.4.22.-).//:swiss|P45436|CED3_CAEVU Cell death protein 3 precursor
(EC 3.4.22.-).
Length = 496
0 100 200 300 400
| | | | | |496
swissnew|P45436|CED3_ | __________________________________________________
Local hits (HSPs) | ______ _________________________
Score = 300 (110.7 bits), Expect = 9.4e-33, Sum P(2) = 9.4e-33
Identities = 86/266 (32%), Positives = 133/266 (50%)
Query: 159 PCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLE 218
P G CLIINN +F + TR G+ D + L F + + V K +++ + M L + +
Sbjct: 235 PRGLCLIINNEHF---EQMPTRNGTKADKDNLTNIFRCMGYTVICKDNISGRGM-LTIRD 290
Query: 219 LAQQD-HGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGG 277
A+ + HG D ++VILSHG + + G D V+V +I ++ N + P L
Sbjct: 291 FAKNETHG--DSAILVILSHGEE-------NVIIGVDDVSVNVHEIYDLLNAANAPRLAN 341
Query: 278 KPKLFFIQACGGEQKDHGFEVASTS---PEDESPGSNPEPDATPFQEGLRTFDQLDAISS 334
KPKL F+QAC GE++D+GF V + P G + D F +R Q
Sbjct: 342 KPKLVFVQACRGERRDNGFPVLDSVDGVPSLIRRGWDNR-DGPNFLGCVRPQAQ-QVWRK 399
Query: 335 LPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSV- 393
P+ +DI + Y+T +VSWR+ GSW+++ + ++F A D+ LL V V+
Sbjct: 400 KPSQADILIRYATTAQYVSWRNSARGSWFIQAVCEVFSTHAKDMDVVELLTEVNKKVACG 459
Query: 394 ----KG--IYKQMPGCFNFLRKKLFF 413
+G I KQMP + L KK +F
Sbjct: 460 FQTSQGANILKQMPEMTSRLLKKFYF 485
Score = 84 (34.6 bits), Expect = 9.4e-33, Sum P(2) = 9.4e-33
Identities = 19/71 (26%), Positives = 39/71 (54%)
Query: 19 ELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLE 78
+LQ +Q+ D L+++++ + I + RD+ ++ + ++ RG +A F L
Sbjct: 20 KLQSEQILDVLIAKDVLNSDNGDMINSCRT--ERDKRKEQVKAVQRRGDEAFDRFYDALR 77
Query: 79 DTGQDMLASFL 89
DTG ++LA+ L
Sbjct: 78 DTGHELLAAVL 88
^ = sptrembl|Q9I8J3|Q9I8J3 Caspase-8.//:trembl|AF273220|AF273220_1 gene:
"casp8"; product: "caspase-8"; Danio rerio caspase-8 (casp8) mRNA,
complete cds. //:gp|AF273220|8778118 caspase-8 [Danio rerio]
Length = 476
0 100 200 300 400
| | | | | |476
sptrembl|Q9I8J3|Q9I8J | __________________________________________________
Local hits (HSPs) | _________________________
Score = 359 (131.4 bits), Expect = 1.3e-32, P = 1.3e-32
Identities = 93/268 (34%), Positives = 144/268 (53%)
Query: 148 NADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDL 207
N + YIL+ P G+CLIINN NF + L RTG+++D ++L + FS +HF +EV+ DL
Sbjct: 225 NPNEYYILTQRPLGYCLIINNYNFLESTNLLKRTGTDMDKDRLAKLFSRMHFQIEVRNDL 284
Query: 208 TAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIF 267
A + + + A ++H ++ V ILSHG + G V GTDG PV + ++ F
Sbjct: 285 EAWAIKDEIKQFANRNHASMGAFVCCILSHGEK-------GTVLGTDGKPVEIREVTLPF 337
Query: 268 NGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFD 327
G C +L KPKLFFIQAC G++ G V ++ +++P + E ++E
Sbjct: 338 AG--CRTLASKPKLFFIQACQGDENQAG--VWTSDGREDAPEEDEE-----YEEDAGII- 387
Query: 328 QLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWA-HSEDLQSLLLR 386
+ +P +D + +T ++S+R K GS +++ L E+ ED+ S+L +
Sbjct: 388 ---VLRKIPIEADFLIGMATVEHYLSYRHTKKGSIFIQELCKKMEELCPKKEDMLSILTK 444
Query: 387 VANAVS---VKGIYKQMPGCFNFLRKKL 411
V VS +KG YKQMP L KKL
Sbjct: 445 VNFEVSKRILKG-YKQMPEPRYTLTKKL 471
^ = pironly|T20038|T20038 hypothetical protein C48D1.2 - Caenorhabditis elegans
Length = 495
0 100 200 300 400
| | | | | |495
pironly|T20038|T20038 | __________________________________________________
Local hits (HSPs) | ______ ______________________
Score = 306 (112.8 bits), Expect = 1.6e-32, Sum P(2) = 1.6e-32
Identities = 77/240 (32%), Positives = 124/240 (51%)
Query: 159 PCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLE 218
P G CLIINN +F + TR G+ D + L F + + V K +LT + M+L + +
Sbjct: 240 PRGMCLIINNEHF---EQMPTRNGTKADKDNLTNLFRCMGYTVICKDNLTGRGMLLTIRD 296
Query: 219 LAQQD-HGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGG 277
A+ + HG D ++VILSHG + + G D P+S +I ++ N + P L
Sbjct: 297 FAKHESHG--DSAILVILSHGEE-------NVIIGVDDIPISTHEIYDLLNAANAPRLAN 347
Query: 278 KPKLFFIQACGGEQKDHGFEVASTS---PEDESPG-SNPEPDATPFQEGLRTFDQLDAI- 332
KPK+ F+QAC GE++D+GF V + P G N + F +R Q+ +
Sbjct: 348 KPKIVFVQACRGERRDNGFPVLDSVDGVPAFLRRGWDNRDGPLFNFLGCVRP--QVQQVW 405
Query: 333 SSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVS 392
P+ +DI ++Y+T +VSWR+ GSW+++ + ++F A D+ LL V V+
Sbjct: 406 RKKPSQADILIAYATTAQYVSWRNSARGSWFIQAVCEVFSTHAKDMDVVELLTEVNKKVA 465
Score = 75 (31.5 bits), Expect = 1.6e-32, Sum P(2) = 1.6e-32
Identities = 18/70 (25%), Positives = 37/70 (52%)
Query: 20 LQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLED 79
L+VD++ + L+++++ + I G+ R++ R+++ ++ RG A F L
Sbjct: 20 LKVDEILEVLIAKQVLNSDNGDMINSCGTV--REKRREIVKAVQRRGDVAFDAFYDALRS 77
Query: 80 TGQDMLASFL 89
TG + LA L
Sbjct: 78 TGHEGLAEVL 87
^ = swissnew|P55866|ICE3_XENLA Apopain precursor (EC 3.4.22.-) (Cysteine
protease CPP32) (Caspase-3) (CASP-3)
(XCPP32).//:swiss|P55866|ICE3_XENLA Apopain precursor (EC 3.4.22.-)
(Cysteine protease CPP32) (Caspase-3) (CASP-3)
(XCPP32).//:trembl|D89784|XLD784_1 gene: "xcpp32"; product:
"XCPP32"; Xenopus laevis mRNA for XCPP32, complete cds.
//:gp|D89784|1752813 XCPP32 [Xenopus laevis]
Length = 282
0 60 120 180 240
| | | | | |282
swissnew|P55866|ICE3_ | __________________________________________________
Local hits (HSPs) | _______________________________________
Score = 247 (92.0 bits), Expect = 1.3e-31, Sum P(2) = 1.3e-31
Identities = 55/147 (37%), Positives = 82/147 (55%)
Query: 161 GHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELA 220
G CLIINN NF S + R G+++D KL F+ L + V V D + ++ L +++
Sbjct: 56 GMCLIINNKNF-HSSNMAVRNGTDVDALKLHETFTGLGYEVMVCNDQKSSDIIGRLKKIS 114
Query: 221 QQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPK 280
++DH V ILSHG + G++ G D P+ ++ + ++F G C +L GKPK
Sbjct: 115 EEDHSKRSSFVCAILSHG------EEDGSICGVD-VPIHIKNLTDLFRGDRCKTLVGKPK 167
Query: 281 LFFIQACGGEQKDHGFEVASTS-PEDE 306
+FFIQAC G + D G E S S P +E
Sbjct: 168 IFFIQACRGTELDSGIETDSCSEPREE 194
Score = 124 (48.7 bits), Expect = 1.3e-31, Sum P(2) = 1.3e-31
Identities = 29/104 (27%), Positives = 51/104 (49%)
Query: 317 TPFQEGLRT---FDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQ 373
T G+ T + + I +P +D +YST PG+ SWRD GSW++++L + +
Sbjct: 177 TELDSGIETDSCSEPREEIQRIPVEADFLYAYSTVPGYCSWRDKMDGSWFIQSLCKMIKL 236
Query: 374 WAHSEDLQSLLLRVANAVSVK----GIYKQMPGCFNFLRKKLFF 413
+ +L +L V + V++ KQ+P + L K +F
Sbjct: 237 YGSHLELIQILTCVNHMVALDFETFHAKKQIPCVVSMLTKSFYF 280
^ = swissnew|P42575|ICE2_HUMAN Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1
protease) (ICH- 1L/1S).//:swiss|P42575|ICE2_HUMAN Caspase-2
precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH-
1L/1S).//:sptremblnew|AAO25653|AAO25653 Caspase 2,
apoptosis-related cysteine protease (neural precursor cell
expressed, developmentally down-regulated
2).//:tremblnew|AY219042|AY219042_1 gene: "CASP2"; product:
"caspase 2, apoptosis-related cysteine protease (neural precursor
cell expressed, developmentally down-regulated 2)"; Homo sapiens
caspase 2, apoptosis-related cysteine protease (neural precursor
cell expressed, developmentally down-regulated 2) (CASP2) gene,
complete cds. //:trembl|U13021|HS13021_1 gene: "Ich-1"; product:
"ICH-1L"; Human positive regulator of programmed cell death ICH-1L
(Ich-1) mRNA, complete cds. //:pironly|A54821|A54821 apoptosis
regulator ICH-1, stimulatory form L - human//:gp|U13021|537292
ICH-1L [Homo sapiens]//:gp|AY219042|27978962 caspase 2,
apoptosis-related cysteine protease (neural precursor cell
expressed, developmentally down-regulated 2) [Homo sapiens]
Length = 435
0 90 180 270 360
| | | | | |435
swissnew|P42575|ICE2_ | __________________________________________________
Local hits (HSPs) | __________________________
Score = 349 (127.9 bits), Expect = 1.5e-31, P = 1.5e-31
Identities = 89/253 (35%), Positives = 130/253 (51%)
Query: 151 LAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAK 210
LAY L P G L+++NV+F E L R+G ++D L F L + V V D TA+
Sbjct: 173 LAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQ 232
Query: 211 KMVLALLELAQQD-HGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNG 269
+M L AQ H D C+V +LSHG + GA+YG DG + ++++ +F+
Sbjct: 233 EMQEKLQNFAQLPAHRVTDSCIVALLSHGVE-------GAIYGVDGKLLQLQEVFQLFDN 285
Query: 270 TSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQL 329
+CPSL KPK+FFIQAC G++ D G + SPG E DA G ++
Sbjct: 286 ANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCE-ESDA-----GKEKLPKM 339
Query: 330 DAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVAN 389
LPT SD+ Y+ G + R+ K GSWY+E L +F + A + +L++V N
Sbjct: 340 ----RLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKV-N 394
Query: 390 AVSVKGIYKQMPG 402
A+ +K PG
Sbjct: 395 AL-IKDREGYAPG 406
^ = trembl|AB038985|AB038985_1 product: "caspase-8"; Homo sapiens gene for
caspase-8, exon 12, exon 13 and complete cds.
//:trembl|U60520|HSU60520_1 gene: "Mch5"; product: "apoptotic
cysteine protease Mch5 isoform alpha"; Human apoptotic cysteine
protease Mch5 isoform alpha (Mch5) mRNA, complete cds.
//:gp|AB038985|12862693 caspase-8 [Homo
sapiens]//:gp|U60520|1401352 apoptotic cysteine protease Mch5
isoform alpha [Homo sapiens]
Length = 496
0 100 200 300 400
| | | | | |496
trembl|AB038985|AB038 | __________________________________________________
Local hits (HSPs) | _________________________
Score = 347 (127.2 bits), Expect = 2.4e-31, P = 2.4e-31
Identities = 95/277 (34%), Positives = 139/277 (50%)
Query: 150 DLAYILSMEPCGHCLIINNVNFC--RES-----GLRTRTGSNIDCEKLRRRFSSLHFMVE 202
D Y + +P G+CLIINN NF RE +R R G+++D L F LHF ++
Sbjct: 240 DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIK 299
Query: 203 VKGDLTAKKMVLALLELAQ-QDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVE 261
D T ++ + +L++ Q DH +DC + ILSHG + G +YGTDG +
Sbjct: 300 PHHDCTVEQ-IYEILKIYQLMDHSNMDCFICCILSHGDK-------GIIYGTDGQEAPIY 351
Query: 262 KIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQE 321
++ + F G CPSL GKPK+FFIQAC G+ G V + S E P+ E
Sbjct: 352 ELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQ------------PYLE 399
Query: 322 GLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL-DDIFEQWAHSEDL 380
+ Q I P +D + +T VS+R+P G+WY+++L + E+ +D+
Sbjct: 400 MDLSSPQTRYI---PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDI 456
Query: 381 QSLLLRVANAVS----VKGIYKQMPGCFNFLRKKLFF 413
++L V VS K + KQMP LRKKL F
Sbjct: 457 LTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVF 493
^ = trembl|AF422925|AF422925_1 gene: "CASP8"; product: "procaspase-8L"; Homo
sapiens procaspase-8L (CASP8) mRNA, complete cds; alternatively
spliced. //:gp|AF422925|19401519 procaspase-8L [Homo sapiens]
Length = 538
0 110 220 330 440
| | | | | |538
trembl|AF422925|AF422 | __________________________________________________
Local hits (HSPs) | _______________________
Score = 348 (127.6 bits), Expect = 3.7e-31, P = 3.7e-31
Identities = 95/277 (34%), Positives = 139/277 (50%)
Query: 150 DLAYILSMEPCGHCLIINNVNFC--RES-----GLRTRTGSNIDCEKLRRRFSSLHFMVE 202
D Y + +P G+CLIINN NF RE +R R G+++D L F LHF ++
Sbjct: 282 DKVYQMKSKPRGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIK 341
Query: 203 VKGDLTAKKMVLALLELAQ-QDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVE 261
D T ++ + +L++ Q DH +DC + ILSHG + G +YGTDG +
Sbjct: 342 PHDDCTVEQ-IYEILKIYQLMDHSNMDCFICCILSHGDK-------GIIYGTDGQEAPIY 393
Query: 262 KIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQE 321
++ + F G CPSL GKPK+FFIQAC G+ G V + S E P+ E
Sbjct: 394 ELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQ------------PYLE 441
Query: 322 GLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL-DDIFEQWAHSEDL 380
+ Q I P +D + +T VS+R+P G+WY+++L + E+ +D+
Sbjct: 442 MDLSSPQTRYI---PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLCQSLRERCPRGDDI 498
Query: 381 QSLLLRVANAVS----VKGIYKQMPGCFNFLRKKLFF 413
++L V VS K + KQMP LRKKL F
Sbjct: 499 LTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVF 535
^ = swissnew|O89110|ICE8_MOUSE Caspase-8 precursor (EC
3.4.22.-).//:swiss|O89110|ICE8_MOUSE Caspase-8 precursor (EC
3.4.22.-).//:trembl|AF067834|AF067834_1 product: "caspase-8"; Mus
musculus caspase-8 mRNA, complete cds.
//:trembl|AF067841|AF067841_1 product: "caspase-8"; Mus musculus
caspase-8 gene, exon 8, complete sequence; and complete cds.
//:trembl|BC006737|BC006737_1 product: "caspase 8"; Mus musculus,
caspase 8, clone MGC:11440 IMAGE:3964119, mRNA, complete cds.
//:gp|AF067834|3193167 caspase-8 [Mus
musculus]//:gp|AF067841|3211998 caspase-8 [Mus
musculus]//:gp|BC006737|13879513 caspase 8 [Mus musculus]
Length = 480
0 100 200 300 400
| | | | | |480
swissnew|O89110|ICE8_ | __________________________________________________
Local hits (HSPs) | __________________________
Score = 334 (122.6 bits), Expect = 5.7e-30, P = 5.7e-30
Identities = 100/278 (35%), Positives = 138/278 (49%)
Query: 149 ADLAYILSMEPCGHCLIINNVNF--CRES-----GLRTRTGSNIDCEKLRRRFSSLHFMV 201
+D Y + +P G+CLIINN +F RE ++ R G++ D E L + F LHF +
Sbjct: 224 SDKVYQMKNKPRGYCLIINNHDFSKAREDITQLRKMKDRKGTDCDKEALSKTFKELHFEI 283
Query: 202 EVKGDLTAKKMVLALLELAQQ-DHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSV 260
D TA + + +LE Q DH DC + ILSHG + G VYGTDG S+
Sbjct: 284 VSYDDCTANE-IHEILEGYQSADHKNKDCFICCILSHGDK-------GVVYGTDGKEASI 335
Query: 261 EKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQ 320
+ + F G+ CPSL GKPK+FFIQAC G G P DE+ G Q
Sbjct: 336 YDLTSYFTGSKCPSLSGKPKIFFIQACQGSNFQKGV------P-DEA-GFEQ-------Q 380
Query: 321 EGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL-DDIFEQWAHSED 379
D + +P +D + +T VS+RDP +G+WY+++L + E+ +D
Sbjct: 381 NHTLEVDSSSHKNYIPDEADFLLGMATVKNCVSYRDPVNGTWYIQSLCQSLRERCPQGDD 440
Query: 380 LQSLLLRVANAVSVKGIY----KQMPGCFNFLRKKLFF 413
+ S+L V VS K KQMP LRKKLFF
Sbjct: 441 ILSILTGVNYDVSNKDDRRNKGKQMPQPTFTLRKKLFF 478
^ = swissnew|O02002|ICE1_DROME Caspase-1 precursor (EC
3.4.22.-).//:swiss|O02002|ICE1_DROME Caspase-1 precursor (EC
3.4.22.-).//:tremblnew|AE003461|AE003461_18 gene: "Dcp-1"; product:
"CG5370-PA"; Drosophila melanogaster chromosome 2R, section 69 of
74 of the complete sequence. //:trembl|AE003461|AE003461_17 gene:
"Dcp-1"; product: "CG5370-PA"; Drosophila melanogaster chromosome
2R, section 69 of 74 of the complete sequence.
//:trembl|AF001464|DMAF1464_1 product: "caspase-1"; Drosophila
melanogaster caspase-1 mRNA, complete cds. //:gp|AF001464|2109453
caspase-1 [Drosophila melanogaster]//:gp|AE003461|7291604 CG5370-PA
[Drosophila melanogaster]//:gpnew|AE003461|7291604 CG5370-PA
[Drosophila melanogaster]
Length = 323
0 70 140 210 280
| | | | | |323
swissnew|O02002|ICE1_ | __________________________________________________
Local hits (HSPs) | ________________________________
Score = 237 (88.5 bits), Expect = 1.0e-28, Sum P(2) = 1.0e-28
Identities = 63/164 (38%), Positives = 88/164 (53%)
Query: 153 YILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKM 212
Y +S + G LI N+ F S L++RTG+N+D ++L++ F +L F V V D + +
Sbjct: 71 YNMSHKHRGVALIFNHEFFDIPS-LKSRTGTNVDAQELKKAFENLGFAVSVHKDCKLRDI 129
Query: 213 VLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSC 272
+ + + A+ DH DC V ILSHG H G +Y D ++ I + F T C
Sbjct: 130 LKHVGKAAELDHTDNDCLAVAILSHG---EH----GYLYAKD-TQYKLDNIWHYFTATFC 181
Query: 273 PSLGGKPKLFFIQACGGEQKDHGF--EVASTSPEDESPGSNPEP 314
PSL GKPKLFFIQAC G++ D G E T + ES S P
Sbjct: 182 PSLAGKPKLFFIQACQGDRLDGGITLEKGVTETDGESSTSYKIP 225
Score = 108 (43.1 bits), Expect = 1.0e-28, Sum P(2) = 1.0e-28
Identities = 25/75 (33%), Positives = 40/75 (53%)
Query: 320 QEGLRTFDQLDAIS-SLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSE 378
++G+ D + S +P +D SYST PG+ SWR+ +GSWY+++L
Sbjct: 208 EKGVTETDGESSTSYKIPIHADFLFSYSTIPGYFSWRNINNGSWYMQSLIRELNANGKKY 267
Query: 379 DLQSLLLRVANAVSV 393
DL +LL V V++
Sbjct: 268 DLLTLLTFVNQRVAL 282
^ = sptremblnew|AAH45046|AAH45046 Hypothetical
protein.//:tremblnew|BC045046|BC045046_1 product: "Unknown (protein
for MGC:53258)"; Xenopus laevis, clone MGC:53258 IMAGE:5569848,
mRNA, complete cds. //:gp|BC045046|27924349 Unknown (protein for
MGC:53258) [Xenopus laevis]
Length = 419
0 90 180 270 360
| | | | | |419
sptremblnew|AAH45046| | __________________________________________________
Local hits (HSPs) | _____________________________________
Score = 317 (116.6 bits), Expect = 3.6e-28, P = 3.6e-28
Identities = 102/339 (30%), Positives = 156/339 (46%)
Query: 19 ELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLE 78
E+ +++L D L+S E+ +M +I S ++ A L+ L RG +A F + L
Sbjct: 23 EMIIEELLDHLVSSEILTNNMHSNIMAYRSDYAQNVA--LLNLLPKRGPRAFSAFCNALH 80
Query: 79 DTGQDMLASFLRTNR--QAAKLSKPTLENLTPV-VLRPEIRKP--EVLRPETPRPVDIGS 133
T Q+ LA + Q ++ P+ V + +P + R +D G
Sbjct: 81 STNQEHLAQQVEKEALLQEEFITSKVHHGSFPLPVQESTLSRPGRQFCREYREESIDDGD 140
Query: 134 GGFG-DVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRR 192
G + ++ + AY + P G L+I+NV F L R G +D L +
Sbjct: 141 GPVTVQLCSVNFYITHCQQAYKMHSCPRGRALLISNVKF-ETPDLDYRCGGEVDLASLEK 199
Query: 193 RFSSLHFMVEVKGDLTAKKMVLALLEL-AQQDHGALDCCVVVILSHGCQASHLQFPGAVY 251
FSSL + V+V+ +L A+ M+ L A H +LD CVV ILSHG GAVY
Sbjct: 200 LFSSLGYQVDVRCNLNAQSMMSQLRAFSALPVHSSLDSCVVAILSHGLD-------GAVY 252
Query: 252 GTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSN 311
GTDG V ++++ + CP L KPK+FF QAC GE+ D G + + SPG
Sbjct: 253 GTDGKLVQLQEVFTALDNAHCPQLQNKPKMFFFQACRGEETDRGVDQRDGREQSGSPGCE 312
Query: 312 PEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPG 350
+ DA +E ++ LPT SD+ +Y+ G
Sbjct: 313 -QSDAG--REDIKV--------RLPTQSDMICAYACLKG 340
^ = swissnew|O01382|ICE_DROME Caspase precursor (EC 3.4.22.-)
(drICE).//:swiss|O01382|ICE_DROME Caspase precursor (EC 3.4.22.-)
(drICE).//:tremblnew|AE003771|AE003771_17 gene: "Ice"; product:
"CG7788-PA"; Drosophila melanogaster chromosome 3R, section 109 of
118 of the complete sequence. //:trembl|AE003771|AE003771_17 gene:
"Ice"; product: "CG7788-PA"; Drosophila melanogaster chromosome
3R, section 109 of 118 of the complete sequence.
//:trembl|AY058451|AY058451_1 gene: "Ice"; product: "GH24292p";
Drosophila melanogaster GH24292 full length cDNA.
//:gp|AY058451|16183280 GH24292p [Drosophila
melanogaster]//:gp|AE003771|7301830 CG7788-PA [Drosophila
melanogaster]//:gpnew|AE003771|7301830 CG7788-PA [Drosophila
melanogaster]
Length = 339
0 70 140 210 280
| | | | | |339
swissnew|O01382|ICE_D | __________________________________________________
Local hits (HSPs) | ___ ____________________ ________
Score = 232 (86.7 bits), Expect = 3.2e-26, Sum P(3) = 3.2e-26
Identities = 56/150 (37%), Positives = 76/150 (50%)
Query: 161 GHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELA 220
G LI N+ +F L++R G+N+DCE L R L F V V D K ++ + A
Sbjct: 94 GMALIFNHEHF-EVPTLKSRAGTNVDCENLTRVLKQLDFEVTVYKDCRYKDILRTIEYAA 152
Query: 221 QQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPK 280
Q+H DC +V ILSHG G +Y D ++ I + F CPSL GKPK
Sbjct: 153 SQNHSDSDCILVAILSHGEM-------GYIYAKD-TQYKLDNIWSFFTANHCPSLAGKPK 204
Query: 281 LFFIQACGGEQKDHGFEVASTSPEDESPGS 310
LFFIQAC G++ D G + + E + S
Sbjct: 205 LFFIQACQGDRLDGGVTMQRSQTETDGDSS 234
Score = 105 (42.0 bits), Expect = 3.2e-26, Sum P(3) = 3.2e-26
Identities = 21/59 (35%), Positives = 33/59 (55%)
Query: 335 LPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSV 393
+P +D ++YST PGF SWR+ GSW++++L D+ +LL V V+V
Sbjct: 239 IPVHADFLIAYSTVPGFYSWRNTTRGSWFMQSLCAELAANGKRLDILTLLTFVCQRVAV 297
Score = 37 (18.1 bits), Expect = 3.2e-26, Sum P(3) = 3.2e-26
Identities = 9/26 (34%), Positives = 11/26 (42%)
Query: 115 IRKPEVLRPETPRPVDIGSGGFGDVG 140
+ PE T +GSGG G G
Sbjct: 17 VGNPEQPNDHTDALGSVGSGGAGSSG 42
^ = swissnew|P55215|ICE2_RAT Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1
protease) (Fragment).//:swiss|P55215|ICE2_RAT Caspase-2 precursor
(EC 3.4.22.-) (CASP-2) (ICH-1 protease) (Fragment).
Length = 312
0 70 140 210 280
| | | | | |312
swissnew|P55215|ICE2_ | __________________________________________________
Local hits (HSPs) | ________________________________________________
Score = 297 (109.6 bits), Expect = 4.7e-26, P = 4.7e-26
Identities = 102/319 (31%), Positives = 143/319 (44%)
Query: 39 MIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKL 98
M E IQ G GS Q +L+ L RG QA F L +T Q L L T +
Sbjct: 4 MRELIQAKG-GSF-SQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTLSDIQH 61
Query: 99 SKPTLEN----------LTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGN 148
P L ++P +L P++L TP + + F AL S
Sbjct: 62 ILPPLSCDYAQVSPSRCMSPALLTSSPAYPQILW-NTPYIMVMVLPVFRWSHALLSFTST 120
Query: 149 ADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLT 208
LAY L P G L+++NV+F E L R+G ++D L F L + V V D T
Sbjct: 121 LQLAYRLQSRPRGLALVMSNVHFTGEKDLEFRSGGDVDHTTLVTLFKLLGYNVHVLYDQT 180
Query: 209 AKKMVLALLELAQQD-HGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIF 267
A++M L AQ H D C+V +LSHG + G +YG DG + ++++ +F
Sbjct: 181 AQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVE-------GGIYGVDGKLLQLQEVFRLF 233
Query: 268 NGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFD 327
+ +CPSL KPK+FFIQAC G++ D G + + PG E D +E L
Sbjct: 234 DNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAQPPGCE-ESDTV--KEELMKM- 289
Query: 328 QLDAISSLPTPSDIFVSYS 346
LPT SD+ Y+
Sbjct: 290 ------RLPTRSDMICVYA 302
^ = trembl|AF052645|AF052645_1 product: "recombinant reversed caspase-3";
Synthetic construct recombinant reversed caspase-3 mRNA, complete
cds. //:gp|AF052645|3170452 recombinant reversed caspase-3
[synthetic construct]
Length = 290
0 60 120 180 240
| | | | | |290
trembl|AF052645|AF052 | __________________________________________________
Local hits (HSPs) | _______________ _______________________
Score = 287 (106.1 bits), Expect = 5.4e-25, P = 5.4e-25
Identities = 60/148 (40%), Positives = 90/148 (60%)
Query: 150 DLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTA 209
D +Y + G C+IINN NF + +G+ +R+G+++D LR F +L + V K DLT
Sbjct: 149 DNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTR 208
Query: 210 KKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNG 269
+++V + +++++DH V V+LSHG + G ++GT+G PV ++KI N F G
Sbjct: 209 EEIVELMRDVSKEDHSKRSSFVCVLLSHGEE-------GIIFGTNG-PVDLKKITNFFRG 260
Query: 270 TSCPSLGGKPKLFFIQACGGEQKDHGFE 297
C SL GKPKLF IQAC G + D G E
Sbjct: 261 DRCRSLTGKPKLFIIQACRGTELDCGIE 288
Score = 131 (51.2 bits), Expect = 1.4e-05, P = 1.4e-05
Identities = 29/93 (31%), Positives = 50/93 (53%)
Query: 331 AISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANA 390
A +P +D +YST PG+ SWR+ K GSW++++L + +Q+A + +L RV
Sbjct: 13 ACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRK 72
Query: 391 VSVK-------GIY---KQMPGCFNFLRKKLFF 413
V+ + + KQ+P + L K+L+F
Sbjct: 73 VATEFESFSFDATFHAKKQIPCIVSMLTKELYF 105
^ = sptrembl|Q8I9V7|Q8I9V7 Caspase-1.//:tremblnew|AF448494|AF448494_1 product:
"caspase-1"; Bombyx mori caspase-1 mRNA, complete cds.
//:gp|AF448494|26985165 caspase-1 [Bombyx mori]
Length = 293
0 60 120 180 240
| | | | | |293
sptrembl|Q8I9V7|Q8I9V | __________________________________________________
Local hits (HSPs) | _______________________ _________
Score = 213 (80.0 bits), Expect = 1.6e-24, Sum P(2) = 1.6e-24
Identities = 51/150 (34%), Positives = 80/150 (53%)
Query: 161 GHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELA 220
G +I N+ +F L++RTG+N+D + L + L F V V +L A+ + + +++
Sbjct: 58 GMAIIFNHEHF-EIHNLKSRTGTNVDSDSLSKVLRGLGFSVTVLHNLRAEDINRYIQQIS 116
Query: 221 QQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPK 280
+ DH DC +V +LSHG L G +Y D + + F CP+L GKPK
Sbjct: 117 EMDHTDNDCLLVAVLSHG----EL---GMLYAKD-THYKPDNLWYYFTADKCPTLAGKPK 168
Query: 281 LFFIQACGGEQKDHGFEVASTSPEDESPGS 310
LFFIQAC G++ D G +++T + S S
Sbjct: 169 LFFIQACQGDKLDGGITLSNTETDGSSSSS 198
Score = 106 (42.4 bits), Expect = 1.6e-24, Sum P(2) = 1.6e-24
Identities = 18/59 (30%), Positives = 34/59 (57%)
Query: 335 LPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSV 393
+P +D + +ST PG+ SWR+ GSW++++L + + D+ +LL V V++
Sbjct: 201 IPIHADFLIVFSTVPGYYSWRNTTRGSWFMQSLCEELRNYGTQRDILTLLTFVCQRVAL 259
^ = trembl|X98174|HSMACHA3_1 product: "MACH-alpha-3"; H.sapiens mRNA for
MACH-alpha-3 protein //:gp|X98174|3928274 MACH-alpha-3 [Homo
sapiens]
Length = 266
0 60 120 180 240
| | | | | |266
trembl|X98174|HSMACHA | __________________________________________________
Local hits (HSPs) | ______________________________________
Score = 278 (102.9 bits), Expect = 4.9e-24, P = 4.9e-24
Identities = 77/230 (33%), Positives = 114/230 (49%)
Query: 190 LRRRFSSLHFMVEVKGDLTAKKMVLALLELAQ-QDHGALDCCVVVILSHGCQASHLQFPG 248
L F LHF ++ D T ++ + +L++ Q DH +DC + ILSHG + G
Sbjct: 57 LTTTFEELHFEIKPHDDCTVEQ-IYEILKIYQLMDHSNMDCFICCILSHGDK-------G 108
Query: 249 AVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESP 308
+YGTDG + ++ + F G CPSL GKPK+FFIQAC G+ G V + S E
Sbjct: 109 IIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQACQGDNYQKGIPVETDSEEQ--- 165
Query: 309 GSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETL- 367
P+ E + Q I P +D + +T VS+R+P G+WY+++L
Sbjct: 166 ---------PYLEMDLSSPQTRYI---PDEADFLLGMATVNNCVSYRNPAEGTWYIQSLC 213
Query: 368 DDIFEQWAHSEDLQSLLLRVANAVS----VKGIYKQMPGCFNFLRKKLFF 413
+ E+ +D+ ++L V VS K + KQMP LRKKL F
Sbjct: 214 QSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVF 263
^ = swissnew|P89116|ICE1_SPOFR Caspase-1 precursor (EC
3.4.22.-).//:swiss|P89116|ICE1_SPOFR Caspase-1 precursor (EC
3.4.22.-).//:trembl|U81510|SFU81510_1 product: "caspase-1";
Spodoptera frugiperda caspase-1 mRNA, complete cds.
//:gp|U81510|1814279 caspase-1 [Spodoptera frugiperda]
Length = 299
0 60 120 180 240
| | | | | |299
swissnew|P89116|ICE1_ | __________________________________________________
Local hits (HSPs) | ________________________ _________
Score = 215 (80.7 bits), Expect = 5.7e-24, Sum P(2) = 5.7e-24
Identities = 53/159 (33%), Positives = 87/159 (54%)
Query: 153 YILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKM 212
Y ++ + G +I N+ +F S L++RTG+N+D + L + +L F V V +L ++++
Sbjct: 53 YNMNHKHRGMAIIFNHEHFDIHS-LKSRTGTNVDSDNLSKVLKTLGFKVTVFPNLKSEEI 111
Query: 213 VLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSC 272
+ + A+ DH DC +V +L+HG L G +Y D + + F C
Sbjct: 112 NKFIQQTAEMDHSDADCLLVAVLTHG----EL---GMLYAKD-THYKPDNLWYYFTADKC 163
Query: 273 PSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSN 311
P+L GKPKLFFIQAC G++ D G ++ T D SP ++
Sbjct: 164 PTLAGKPKLFFIQACQGDRLDGGITLSRTET-DGSPSTS 201
Score = 103 (41.3 bits), Expect = 5.7e-24, Sum P(2) = 5.7e-24
Identities = 18/59 (30%), Positives = 33/59 (55%)
Query: 335 LPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSV 393
+P +D +++ST PG+ SWR+ GSW+++ L + D+ +LL V V++
Sbjct: 204 IPVHADFLIAFSTVPGYFSWRNTTRGSWFMQALCEELRYAGTERDILTLLTFVCQKVAL 262
^ = sptrembl|Q9IB65|Q9IB65 Caspase-7.//:trembl|AB038170|AB038170_1 gene:
"xCaspase-7"; product: "caspase-7"; Xenopus laevis mRNA for
caspase-7, complete cds. //:gp|AB038170|7619904 caspase-7 [Xenopus
laevis]
Length = 318
0 70 140 210 280
| | | | | |318
sptrembl|Q9IB65|Q9IB6 | __________________________________________________
Local hits (HSPs) | _____________________________________
Score = 272 (100.8 bits), Expect = 2.3e-23, P = 2.3e-23
Identities = 71/177 (40%), Positives = 94/177 (53%)
Query: 161 GHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELA 220
G C+IINN F + +G+ R G++ID +L R F L F V V + + ++M L +A
Sbjct: 79 GRCIIINNKIFDKITGMGARNGTDIDARELLRCFKGLGFDVNVYNNKSCEEMENLLRTVA 138
Query: 221 QQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGC-PVSVEKIVNIFNGTSCPSLGGKP 279
QQDH C + LSHG + G +YGTDG P+ V + +F G +C SL GKP
Sbjct: 139 QQDHKDSACFACIFLSHGEE-------GLIYGTDGAMPIKV--LTTLFRGDNCRSLVGKP 189
Query: 280 KLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLP 336
KLFFIQAC G + D G E S S D E DA P + D L A S++P
Sbjct: 190 KLFFIQACRGHEFDDGLEADSGSVNDSL-----ETDANPRHKIPVEADFLYAYSTVP 241
Score = 134 (52.2 bits), Expect = 8.1e-06, P = 8.1e-06
Identities = 33/113 (29%), Positives = 56/113 (49%)
Query: 313 EPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFE 372
E D+ + L T + +P +D +YST PG+ SWR+P GSW+V+ L +
Sbjct: 207 EADSGSVNDSLET--DANPRHKIPVEADFLYAYSTVPGYYSWRNPGMGSWFVQALCSVLN 264
Query: 373 QWAHSEDLQSLLLRVANAVSVK-GIY---------KQMPGCFNFLRKKLFFKT 415
++ ++ +L RV V+ + Y KQ+P + L K+L+FK+
Sbjct: 265 EYGKELEVMQILTRVNFLVATQFESYSDDPQFSKKKQIPCVVSMLTKELYFKS 317
^ = sptrembl|Q9IB62|Q9IB62 Caspase-10.//:trembl|AB038173|AB038173_1 gene:
"xCaspase-10"; product: "caspase-10"; Xenopus laevis mRNA for
caspase-10, complete cds. //:gp|AB038173|7619910 caspase-10
[Xenopus laevis]
Length = 520
0 110 220 330 440
| | | | | |520
sptrembl|Q9IB62|Q9IB6 | __________________________________________________
Local hits (HSPs) | ____________ __________
Score = 196 (74.1 bits), Expect = 3.9e-21, Sum P(2) = 3.9e-21
Identities = 54/137 (39%), Positives = 74/137 (54%)
Query: 153 YILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKM 212
Y ++ + G+CLII+N F + G R R GS+ D L FS L VE+ +L +++
Sbjct: 268 YHMNHKHRGYCLIIDNSIFMK--GKR-REGSDKDAGALSDVFSWLGLEVEIVKNLGTEQI 324
Query: 213 VLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSC 272
L +DH DC V IL+HG G V G+D VS+ ++++ F TSC
Sbjct: 325 RGCLKRFKSKDHSERDCFVCCILTHGES-------GTVMGSDDKEVSIREVMSYFTATSC 377
Query: 273 PSLGGKPKLFFIQACGG 289
SL KPKLFFIQAC G
Sbjct: 378 ISLTLKPKLFFIQACQG 394
Score = 126 (49.4 bits), Expect = 3.9e-21, Sum P(2) = 3.9e-21
Identities = 38/112 (33%), Positives = 57/112 (50%)
Query: 308 PGSNPEPDAT-PFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVET 366
P S EPDA+ P + + + I ++P +D + ST G+ ++R K GSWY++
Sbjct: 399 PSSKVEPDASVPVEH--KKY-----IVNVPKEADFLLGMSTVDGYAAYRHKKYGSWYIQA 451
Query: 367 L-DDIFEQWAHSEDLQSLLLRVANAVSVKGI----YKQMPGCFNFLRKKLFF 413
L ++ E ED+ S+L +V VS+K KQMP L KKL F
Sbjct: 452 LCKNLVEMVPRGEDILSILTKVNKDVSLKEDSEQKLKQMPQPAYTLLKKLIF 503
^ = sptrembl|Q9GV88|Q9GV88 Caspase 3B.//:trembl|AF155128|AF155128_1 product:
"caspase 3B"; Hydra vulgaris caspase 3B mRNA, complete cds.
//:gp|AF155128|9754624 caspase 3B [Hydra vulgaris]
Length = 326
0 70 140 210 280
| | | | | |326
sptrembl|Q9GV88|Q9GV8 | __________________________________________________
Local hits (HSPs) | _____________________________________
Score = 175 (66.7 bits), Expect = 9.7e-21, Sum P(2) = 9.7e-21
Identities = 52/171 (30%), Positives = 84/171 (49%)
Query: 148 NADLAYILSMEPCGHCLIINNVNFCRESGLRT--RTGSNIDCEKLRRRFSSLHFMVEVKG 205
N+D Y + P G IIN NF + S R G+++D E L F L F ++
Sbjct: 71 NSDNFYNTNTFPRGTLTIINVKNFMKSSNKHEYPRLGTDVDAESLCDLFLKLGFKIDRLN 130
Query: 206 DLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVN 265
+ + ++ L + A +D+ ++ CCVV +LSHG + G + T+ +++ +I N
Sbjct: 131 NPKSTDVLNILKQAANEDYSSMSCCVVALLSHGEE-------GKIICTNES-LNIREITN 182
Query: 266 IFNGTSCP-SLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPD 315
+F C +L GKPKLF IQAC G + + + PG + EP+
Sbjct: 183 LF----CTKALAGKPKLFLIQACRGTEYMESLDTV----DGLGPGLSNEPN 225
Score = 136 (52.9 bits), Expect = 9.7e-21, Sum P(2) = 9.7e-21
Identities = 39/113 (34%), Positives = 52/113 (46%)
Query: 317 TPFQEGLRTFDQLD-AISSLPT------PSDIFVSYSTFPGFVSWRDPKSGSWYVETLDD 369
T + E L T D L +S+ P SD +YST G+ SW K GSW++
Sbjct: 204 TEYMESLDTVDGLGPGLSNEPNVLDVTVESDFLYAYSTVLGYYSWSSQKLGSWFINAAVS 263
Query: 370 IFEQWAHSEDLQSLLLRVANAVS---------VKGIYKQMPGCFNFLRKKLFF 413
+F +AH D+ LL RV VS K KQ+ + LRK+LFF
Sbjct: 264 VFRDYAHKMDVLRLLTRVNKEVSEKTSITDNLTKDNKKQIGSLISLLRKELFF 316
^ = trembl|U13022|HS13022_1 gene: "Ich-1"; product: "ICH-1S"; Human negative
regulator of programmed cell death ICH-1S (Ich-1) mRNA, complete
cds. //:trembl|AX134407|AX134407_1 unnamed ORF; Sequence 3 from
Patent WO0129232. //:pironly|B54821|B54821 apoptosis regulator
ICH-1, suppressive form S - human//:gp|U13022|537294 ICH-1S [Homo
sapiens]//:gp|AX134407|14271054 unnamed protein product [Homo
sapiens]
Length = 312
0 70 140 210 280
| | | | | |312
trembl|U13022|HS13022 | __________________________________________________
Local hits (HSPs) | _____________________
Score = 247 (92.0 bits), Expect = 2.0e-20, P = 2.0e-20
Identities = 56/140 (40%), Positives = 79/140 (56%)
Query: 151 LAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAK 210
LAY L P G L+++NV+F E L R+G ++D L F L + V V D TA+
Sbjct: 159 LAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQ 218
Query: 211 KMVLALLELAQQD-HGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNG 269
+M L AQ H D C+V +LSHG + GA+YG DG + ++++ +F+
Sbjct: 219 EMQEKLQNFAQLPAHRVTDSCIVALLSHGVE-------GAIYGVDGKLLQLQEVFQLFDN 271
Query: 270 TSCPSLGGKPKLFFIQACGG 289
+CPSL KPK+FFIQAC G
Sbjct: 272 ANCPSLQNKPKMFFIQACRG 291
^ = swissnew|P55214|ICE7_MESAU Caspase-7 precursor (EC 3.4.22.-) (ICE-like
apoptotic protease 3) (ICE-LAP3) (Apoptotic protease Mch-3) (SREBP
cleavage activity 2) (SCA-2).//:swiss|P55214|ICE7_MESAU Caspase-7
precursor (EC 3.4.22.-) (ICE-like apoptotic protease 3) (ICE-LAP3)
(Apoptotic protease Mch-3) (SREBP cleavage activity 2)
(SCA-2).//:trembl|U47332|MA47332_1 product: "MCH3/SCA-2";
Mesocricetus auratus MCH3/SCA-2 mRNA, complete cds.
//:gp|U47332|1245144 MCH3/SCA-2 [Mesocricetus auratus]
Length = 303
0 60 120 180 240 300
| | | | | |303
swissnew|P55214|ICE7_ | __________________________________________________
Local hits (HSPs) | _______________________________________
Score = 244 (91.0 bits), Expect = 4.3e-20, P = 4.3e-20
Identities = 60/160 (37%), Positives = 86/160 (53%)
Query: 153 YILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKM 212
Y + E G C+IINN NF + +G+ R G++ D E L + F SL F V V D + KM
Sbjct: 60 YRMDFEKMGKCIIINNKNFDKVTGMDVRNGTDKDAEALFKCFRSLGFDVVVYNDCSCAKM 119
Query: 213 VLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSC 272
L + +++DH C V+LSHG + +YG DG ++ + F G C
Sbjct: 120 QDLLRKASEEDHSNSACFACVLLSHGEE-------NLIYGKDGV-TPIKDLTAHFRGDRC 171
Query: 273 PSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNP 312
+L KPKLFFIQAC G + D G + A + P +E+ +NP
Sbjct: 172 KTLLEKPKLFFIQACRGTELDDGVQ-ADSGPINETD-ANP 209
Score = 196 (74.1 bits), Expect = 3.7e-13, P = 3.7e-13
Identities = 58/176 (32%), Positives = 87/176 (49%)
Query: 250 VYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPG 309
+YG DG ++ + F G C +L KPKLFFIQAC G + D G + A + P +E+
Sbjct: 150 IYGKDGV-TPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGVQ-ADSGPINET-- 205
Query: 310 SNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDD 369
DA P + +P +D +YST PG+ SWR+P GSW+V+ L
Sbjct: 206 -----DANPRYK-------------IPVEADFLFAYSTVPGYYSWRNPGKGSWFVQALCS 247
Query: 370 IFEQWAHSEDLQ--SLLLRVANAVSVK----------GIYKQMPGCFNFLRKKLFF 413
I ++ H +DL+ +L RV + V+ KQ+P + L K+L+F
Sbjct: 248 ILDE--HGKDLEIMQILTRVNDRVARHFESQCDDPCFNEKKQIPCMVSMLTKELYF 301
WARNING: HSPs involving 72 database sequences were not reported due to the
limiting value of parameter B = 50.
Parameters:
matrix=BLOSUM62
E=10
V=250
B=50
hspmax=10
filter=seg
echofilter
stats
qtype
qres
ctxfactor=1.00
Query ----- As Used ----- ----- Computed ----
Frame MatID Matrix name Lambda K H Lambda K H
+0 0 BLOSUM62 0.320 0.138 0.415 same same same
Q=9,R=2 0.244 0.0300 0.180 n/a n/a n/a
Query
Frame MatID Length Eff.Length E S W T X E2 S2
+0 0 416 416 10. 82 3 11 22 0.20 34
34 0.22 37
Statistics:
Query Expected Observed HSPs HSPs
Frame MatID High Score High Score Reportable Reported
+0 0 72 (33.2 bits) 2111 (973.9 bits) 188 85
Query Neighborhd Word Excluded Failed Successful Overlaps
Frame MatID Words Hits Hits Extensions Extensions Excluded
+0 0 9809 189346525 40300170 148822569 223786 917
Database: /dove2/data/db/nrdb95
Title: nrdb-95% Rel.02.04.2003
Release date: unknown
Posted date: 10:18:45 AM MDT Apr 2, 2003
Last modified: unknown
First created: unknown
Format: BLAST-1.4
# of letters in database: 229,823,634
# of sequences in database: 701,238
# of database sequences satisfying E: 122
No. of states in DFA: 575 (113 KB)
Total size of DFA: 315 KB (320 KB)
Time to generate neighborhood: 0.02u 0.01s 0.03t Elapsed: 00:00:00
No. of threads or processors used: 4
Search cpu time: 261.79u 2.98s 264.77t Elapsed: 00:01:09
Total cpu time: 261.96u 3.09s 265.05t Elapsed: 00:01:09
Start: Wed Apr 2 11:53:27 2003 End: Wed Apr 2 11:54:36 2003
WARNINGS ISSUED: 1
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