BLASTP 2.2.3 [Apr-24-2002]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= d1bgc__:a.26.1.1
(165 letters)
Database: /data/tmp/fabascal/DBASE/scop+nr100.faa.nrdb90.reformated
475,909 sequences; 166,026,790 total letters
Searching..................................................done
Results from round 1
Score E
Sequences producing significant alignments: (bits) Value
scop|:d1bgc__:a.26.1.1 (d1bgc__:a.26.1.1) 275 1e-73
tr|:Q9GJU0 (Q9GJU0) Granulocyte colony-stimulating factor precu 232 6e-61
sp|:CSF3_PIG (O02837) Granulocyte colony-stimulating factor pre 230 3e-60
sp|:CSF3_HUMAN (P09919) Granulocyte colony-stimulating factor p 217 3e-56
tr|:P97712 (P97712) Granulocyte colony stimulating factor 196 7e-50
sp|:CSF3_MOUSE (P09920) Granulocyte colony-stimulating factor p 187 2e-47
tn|:AAM34205 (AAM34205) Granulocyte colony-stimulating factor 151 2e-36
sp|:MGF_CHICK (P13854) Myelomonocytic growth factor precursor ( 98 2e-20
>scop|:d1bgc__:a.26.1.1 (d1bgc__:a.26.1.1)
Length = 165
Score = 275 bits (702), Expect = 1e-73
Identities = 154/165 (93%), Positives = 154/165 (93%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXX 60
SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP
Sbjct: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPLSSCSSQ 60
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
RGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA
Sbjct: 61 SLQLRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
Query: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA
Sbjct: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
>tr|:Q9GJU0 (Q9GJU0) Granulocyte colony-stimulating factor precu
Length = 195
Score = 232 bits (592), Expect = 6e-61
Identities = 128/163 (78%), Positives = 135/163 (82%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXX 60
SLPQSFLLKCLEQVRK+QADG LQERLCAAHKLCHPEEL+LL H+LGIPQAP
Sbjct: 29 SLPQSFLLKCLEQVRKVQADGTALQERLCAAHKLCHPEELVLLGHALGIPQAPLSSCSSQ 88
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
GCL QLH GLFLYQGLLQALAGISPELAPTLD LQLD+TDFA NIW QMED+G A
Sbjct: 89 ALQLTGCLRQLHSGLFLYQGLLQALAGISPELAPTLDMLQLDITDFAINIWQQMEDVGMA 148
Query: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRY 163
PAV PTQG MPTFTSAFQRRAGG LVAS L FLE+AYR LR+
Sbjct: 149 PAVPPTQGTMPTFTSAFQRRAGGTLVASNLQSFLEVAYRALRH 191
>sp|:CSF3_PIG (O02837) Granulocyte colony-stimulating factor pre
Length = 195
Score = 230 bits (586), Expect = 3e-60
Identities = 133/165 (80%), Positives = 137/165 (82%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXX 60
SLPQSFLLKCLEQVRKIQADGAELQERLCA HKLCHP+EL+LL HSLG+PQA
Sbjct: 29 SLPQSFLLKCLEQVRKIQADGAELQERLCATHKLCHPQELVLLGHSLGLPQASLSSCSSQ 88
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
GCLNQLHGGL LYQGLLQALAGISPELAP LD LQLDVTD ATNIWLQMEDL A
Sbjct: 89 ALQLTGCLNQLHGGLVLYQGLLQALAGISPELAPALDILQLDVTDLATNIWLQMEDLRMA 148
Query: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
PA PTQG +PTFTSAFQRRAGGVLV SQL FLELAYR LRYLA
Sbjct: 149 PASLPTQGTVPTFTSAFQRRAGGVLVVSQLQSFLELAYRVLRYLA 193
>sp|:CSF3_HUMAN (P09919) Granulocyte colony-stimulating factor p
Length = 207
Score = 217 bits (552), Expect = 3e-56
Identities = 126/168 (75%), Positives = 135/168 (80%), Gaps = 3/168 (1%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERL---CAAHKLCHPEELMLLRHSLGIPQAPXXXX 57
SLPQSFLLKCLEQVRKIQ DGA LQE+L CA +KLCHPEEL+LL HSLGIP AP
Sbjct: 38 SLPQSFLLKCLEQVRKIQGDGAALQEKLVSECATYKLCHPEELVLLGHSLGIPWAPLSSC 97
Query: 58 XXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDL 117
GCL+QLH GLFLYQGLLQAL GISPEL PTLDTLQLDV DFAT IW QME+L
Sbjct: 98 PSQALQLAGCLSQLHSGLFLYQGLLQALEGISPELGPTLDTLQLDVADFATTIWQQMEEL 157
Query: 118 GAAPAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
G APA+QPTQGAMP F SAFQRRAGGVLVAS L FLE++YR LR+LA
Sbjct: 158 GMAPALQPTQGAMPAFASAFQRRAGGVLVASHLQSFLEVSYRVLRHLA 205
>tr|:P97712 (P97712) Granulocyte colony stimulating factor
Length = 214
Score = 196 bits (497), Expect = 7e-50
Identities = 111/163 (68%), Positives = 120/163 (73%)
Query: 2 LPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXX 61
LP+SFLLK LEQVRKIQA EL E+LCA +KLCHPEEL+L HSLGIP+A
Sbjct: 36 LPRSFLLKSLEQVRKIQARNTELLEQLCATYKLCHPEELVLFGHSLGIPKASLSSCSSQA 95
Query: 62 XXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAP 121
CL+QLH GLFLYQGLLQALAGIS ELAPTLD L LDV +FAT IW QME LG AP
Sbjct: 96 LQQTKCLSQLHSGLFLYQGLLQALAGISSELAPTLDMLHLDVDNFATTIWQQMESLGVAP 155
Query: 122 AVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYL 164
VQPTQ MP FTSAFQRRAGGVLV S L FLE A+ L +L
Sbjct: 156 TVQPTQSTMPIFTSAFQRRAGGVLVTSYLQSFLETAHHALHHL 198
>sp|:CSF3_MOUSE (P09920) Granulocyte colony-stimulating factor p
Length = 208
Score = 187 bits (475), Expect = 2e-47
Identities = 112/164 (68%), Positives = 123/164 (74%)
Query: 2 LPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXX 61
LP+SFLLK LEQVRKIQA G+ L E+LCA +KLCHPEEL+LL HSLGIP+A
Sbjct: 45 LPRSFLLKSLEQVRKIQASGSVLLEQLCATYKLCHPEELVLLGHSLGIPKASLSGCSSQA 104
Query: 62 XXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAP 121
CL+QLH GL LYQGLLQAL+GISP LAPTLD LQLDV +FAT IW QME+LG AP
Sbjct: 105 LQQTQCLSQLHSGLCLYQGLLQALSGISPALAPTLDLLQLDVANFATTIWQQMENLGVAP 164
Query: 122 AVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
VQPTQ AMP FTSAFQRRAGGVL S L FLE A L +LA
Sbjct: 165 TVQPTQSAMPAFTSAFQRRAGGVLAISYLQGFLETARLALHHLA 208
>tn|:AAM34205 (AAM34205) Granulocyte colony-stimulating factor
Length = 127
Score = 151 bits (381), Expect = 2e-36
Identities = 98/125 (78%), Positives = 99/125 (78%)
Query: 41 MLLRHSLGIPQAPXXXXXXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQ 100
MLL HSLGIPQ GCL+QLH GL LYQGLLQALAGISPELAPTLD LQ
Sbjct: 1 MLLGHSLGIPQPLLSSCSSQALQLTGCLSQLHSGLLLYQGLLQALAGISPELAPTLDMLQ 60
Query: 101 LDVTDFATNIWLQMEDLGAAPAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRG 160
LDVTDFATNIW QMEDLG AP VQPT G MPTF SAFQRRAGGVLVAS L RFLELAYRG
Sbjct: 61 LDVTDFATNIWQQMEDLGVAPVVQPTHGPMPTFASAFQRRAGGVLVASNLQRFLELAYRG 120
Query: 161 LRYLA 165
LRYLA
Sbjct: 121 LRYLA 125
>sp|:MGF_CHICK (P13854) Myelomonocytic growth factor precursor (
Length = 201
Score = 97.8 bits (242), Expect = 2e-20
Identities = 63/164 (38%), Positives = 84/164 (50%), Gaps = 2/164 (1%)
Query: 4 QSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXXXX 63
Q FL K LE RKI+ D A LQ +C +LC EEL L++ + QAP
Sbjct: 36 QLFLHKNLEFTRKIRGDVAALQRAVCDTFQLCTEEELQLVQPDPHLVQAPLDQCHKRGFQ 95
Query: 64 XRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAV 123
C Q+ GL Y L A+ + P ++TLQLD + ++NI QMEDLG
Sbjct: 96 AEVCFTQIRAGLHAYHDSLGAVLRLLPNHTTLVETLQLDAANLSSNIQQQMEDLGLDTVT 155
Query: 124 QPTQ--GAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
P + PTF+ FQ++ GG + + RFLE AYR LR+LA
Sbjct: 156 LPAEQRSPPPTFSGPFQQQVGGFFILANFQRFLETAYRALRHLA 199
Searching..................................................done
Results from round 2
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
scop|:d1bgc__:a.26.1.1 (d1bgc__:a.26.1.1) 261 1e-69
tr|:Q9GJU0 (Q9GJU0) Granulocyte colony-stimulating factor precu 257 2e-68
sp|:CSF3_HUMAN (P09919) Granulocyte colony-stimulating factor p 250 4e-66
sp|:CSF3_PIG (O02837) Granulocyte colony-stimulating factor pre 247 2e-65
tr|:P97712 (P97712) Granulocyte colony stimulating factor 244 1e-64
sp|:CSF3_MOUSE (P09920) Granulocyte colony-stimulating factor p 236 5e-62
sp|:MGF_CHICK (P13854) Myelomonocytic growth factor precursor ( 215 6e-56
tn|:AAM34205 (AAM34205) Granulocyte colony-stimulating factor 170 3e-42
Sequences not found previously or not previously below threshold:
tr|:Q90YI0 (Q90YI0) Interleukin-6 precursor 52 2e-06
>scop|:d1bgc__:a.26.1.1 (d1bgc__:a.26.1.1)
Length = 165
Score = 261 bits (668), Expect = 1e-69
Identities = 154/165 (93%), Positives = 154/165 (93%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXX 60
SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP
Sbjct: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPLSSCSSQ 60
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
RGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA
Sbjct: 61 SLQLRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
Query: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA
Sbjct: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
>tr|:Q9GJU0 (Q9GJU0) Granulocyte colony-stimulating factor precu
Length = 195
Score = 257 bits (658), Expect = 2e-68
Identities = 128/163 (78%), Positives = 135/163 (82%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXX 60
SLPQSFLLKCLEQVRK+QADG LQERLCAAHKLCHPEEL+LL H+LGIPQAP
Sbjct: 29 SLPQSFLLKCLEQVRKVQADGTALQERLCAAHKLCHPEELVLLGHALGIPQAPLSSCSSQ 88
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
GCL QLH GLFLYQGLLQALAGISPELAPTLD LQLD+TDFA NIW QMED+G A
Sbjct: 89 ALQLTGCLRQLHSGLFLYQGLLQALAGISPELAPTLDMLQLDITDFAINIWQQMEDVGMA 148
Query: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRY 163
PAV PTQG MPTFTSAFQRRAGG LVAS L FLE+AYR LR+
Sbjct: 149 PAVPPTQGTMPTFTSAFQRRAGGTLVASNLQSFLEVAYRALRH 191
>sp|:CSF3_HUMAN (P09919) Granulocyte colony-stimulating factor p
Length = 207
Score = 250 bits (638), Expect = 4e-66
Identities = 126/168 (75%), Positives = 135/168 (80%), Gaps = 3/168 (1%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERL---CAAHKLCHPEELMLLRHSLGIPQAPXXXX 57
SLPQSFLLKCLEQVRKIQ DGA LQE+L CA +KLCHPEEL+LL HSLGIP AP
Sbjct: 38 SLPQSFLLKCLEQVRKIQGDGAALQEKLVSECATYKLCHPEELVLLGHSLGIPWAPLSSC 97
Query: 58 XXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDL 117
GCL+QLH GLFLYQGLLQAL GISPEL PTLDTLQLDV DFAT IW QME+L
Sbjct: 98 PSQALQLAGCLSQLHSGLFLYQGLLQALEGISPELGPTLDTLQLDVADFATTIWQQMEEL 157
Query: 118 GAAPAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
G APA+QPTQGAMP F SAFQRRAGGVLVAS L FLE++YR LR+LA
Sbjct: 158 GMAPALQPTQGAMPAFASAFQRRAGGVLVASHLQSFLEVSYRVLRHLA 205
>sp|:CSF3_PIG (O02837) Granulocyte colony-stimulating factor pre
Length = 195
Score = 247 bits (631), Expect = 2e-65
Identities = 133/165 (80%), Positives = 137/165 (82%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXX 60
SLPQSFLLKCLEQVRKIQADGAELQERLCA HKLCHP+EL+LL HSLG+PQA
Sbjct: 29 SLPQSFLLKCLEQVRKIQADGAELQERLCATHKLCHPQELVLLGHSLGLPQASLSSCSSQ 88
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
GCLNQLHGGL LYQGLLQALAGISPELAP LD LQLDVTD ATNIWLQMEDL A
Sbjct: 89 ALQLTGCLNQLHGGLVLYQGLLQALAGISPELAPALDILQLDVTDLATNIWLQMEDLRMA 148
Query: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
PA PTQG +PTFTSAFQRRAGGVLV SQL FLELAYR LRYLA
Sbjct: 149 PASLPTQGTVPTFTSAFQRRAGGVLVVSQLQSFLELAYRVLRYLA 193
>tr|:P97712 (P97712) Granulocyte colony stimulating factor
Length = 214
Score = 244 bits (624), Expect = 1e-64
Identities = 111/163 (68%), Positives = 120/163 (73%)
Query: 2 LPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXX 61
LP+SFLLK LEQVRKIQA EL E+LCA +KLCHPEEL+L HSLGIP+A
Sbjct: 36 LPRSFLLKSLEQVRKIQARNTELLEQLCATYKLCHPEELVLFGHSLGIPKASLSSCSSQA 95
Query: 62 XXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAP 121
CL+QLH GLFLYQGLLQALAGIS ELAPTLD L LDV +FAT IW QME LG AP
Sbjct: 96 LQQTKCLSQLHSGLFLYQGLLQALAGISSELAPTLDMLHLDVDNFATTIWQQMESLGVAP 155
Query: 122 AVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYL 164
VQPTQ MP FTSAFQRRAGGVLV S L FLE A+ L +L
Sbjct: 156 TVQPTQSTMPIFTSAFQRRAGGVLVTSYLQSFLETAHHALHHL 198
>sp|:CSF3_MOUSE (P09920) Granulocyte colony-stimulating factor p
Length = 208
Score = 236 bits (602), Expect = 5e-62
Identities = 112/164 (68%), Positives = 123/164 (74%)
Query: 2 LPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXX 61
LP+SFLLK LEQVRKIQA G+ L E+LCA +KLCHPEEL+LL HSLGIP+A
Sbjct: 45 LPRSFLLKSLEQVRKIQASGSVLLEQLCATYKLCHPEELVLLGHSLGIPKASLSGCSSQA 104
Query: 62 XXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAP 121
CL+QLH GL LYQGLLQAL+GISP LAPTLD LQLDV +FAT IW QME+LG AP
Sbjct: 105 LQQTQCLSQLHSGLCLYQGLLQALSGISPALAPTLDLLQLDVANFATTIWQQMENLGVAP 164
Query: 122 AVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
VQPTQ AMP FTSAFQRRAGGVL S L FLE A L +LA
Sbjct: 165 TVQPTQSAMPAFTSAFQRRAGGVLAISYLQGFLETARLALHHLA 208
>sp|:MGF_CHICK (P13854) Myelomonocytic growth factor precursor (
Length = 201
Score = 215 bits (549), Expect = 6e-56
Identities = 63/164 (38%), Positives = 84/164 (50%), Gaps = 2/164 (1%)
Query: 4 QSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXXXX 63
Q FL K LE RKI+ D A LQ +C +LC EEL L++ + QAP
Sbjct: 36 QLFLHKNLEFTRKIRGDVAALQRAVCDTFQLCTEEELQLVQPDPHLVQAPLDQCHKRGFQ 95
Query: 64 XRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAV 123
C Q+ GL Y L A+ + P ++TLQLD + ++NI QMEDLG
Sbjct: 96 AEVCFTQIRAGLHAYHDSLGAVLRLLPNHTTLVETLQLDAANLSSNIQQQMEDLGLDTVT 155
Query: 124 QPTQ--GAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
P + PTF+ FQ++ GG + + RFLE AYR LR+LA
Sbjct: 156 LPAEQRSPPPTFSGPFQQQVGGFFILANFQRFLETAYRALRHLA 199
>tn|:AAM34205 (AAM34205) Granulocyte colony-stimulating factor
Length = 127
Score = 170 bits (431), Expect = 3e-42
Identities = 98/125 (78%), Positives = 99/125 (78%)
Query: 41 MLLRHSLGIPQAPXXXXXXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQ 100
MLL HSLGIPQ GCL+QLH GL LYQGLLQALAGISPELAPTLD LQ
Sbjct: 1 MLLGHSLGIPQPLLSSCSSQALQLTGCLSQLHSGLLLYQGLLQALAGISPELAPTLDMLQ 60
Query: 101 LDVTDFATNIWLQMEDLGAAPAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRG 160
LDVTDFATNIW QMEDLG AP VQPT G MPTF SAFQRRAGGVLVAS L RFLELAYRG
Sbjct: 61 LDVTDFATNIWQQMEDLGVAPVVQPTHGPMPTFASAFQRRAGGVLVASNLQRFLELAYRG 120
Query: 161 LRYLA 165
LRYLA
Sbjct: 121 LRYLA 125
>tr|:Q90YI0 (Q90YI0) Interleukin-6 precursor
Length = 241
Score = 51.7 bits (123), Expect = 2e-06
Identities = 34/165 (20%), Positives = 61/165 (36%), Gaps = 9/165 (5%)
Query: 7 LLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP-XXXXXXXXXXXR 65
LL C R ++ +LQ+ +C +C ML+R++L +P+
Sbjct: 71 LLDCEPLARVLRDRAVQLQDEMCKKFTVCENSMEMLVRNNLNLPKVTEEDGCLLAGFDEE 130
Query: 66 GCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQP 125
CL +L GLF +Q L+ + +++L A I + + V P
Sbjct: 131 KCLTKLSSGLFAFQTYLEFIQETFDSEKQNVESLCYSTKHLAATIRQMV--INPDEVVIP 188
Query: 126 TQGAMPTFTSAFQ------RRAGGVLVASQLHRFLELAYRGLRYL 164
A + + + + L+ F+E R +RYL
Sbjct: 189 DSAAQKSLLANLKSDKDWIEKITMHLILRDFTSFMEKTVRAVRYL 233
Searching..................................................done
Results from round 3
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
scop|:d1bgc__:a.26.1.1 (d1bgc__:a.26.1.1) 253 4e-67
tr|:Q9GJU0 (Q9GJU0) Granulocyte colony-stimulating factor precu 247 3e-65
sp|:CSF3_HUMAN (P09919) Granulocyte colony-stimulating factor p 242 7e-64
sp|:CSF3_PIG (O02837) Granulocyte colony-stimulating factor pre 236 3e-62
tr|:P97712 (P97712) Granulocyte colony stimulating factor 235 7e-62
sp|:CSF3_MOUSE (P09920) Granulocyte colony-stimulating factor p 226 4e-59
sp|:MGF_CHICK (P13854) Myelomonocytic growth factor precursor ( 205 8e-53
tr|:Q90YI0 (Q90YI0) Interleukin-6 precursor 196 5e-50
tn|:AAM34205 (AAM34205) Granulocyte colony-stimulating factor 164 3e-40
Sequences not found previously or not previously below threshold:
tr|:Q9XT80 (Q9XT80) Interleukin 6 81 2e-15
sp|:IL6_PIG (P26893) Interleukin-6 precursor (IL-6) 79 1e-14
sp|:IL6_HORSE (Q95181) Interleukin-6 precursor (IL-6) 78 2e-14
sp|:IL6_CANFA (P41323) Interleukin-6 precursor (IL-6) 75 2e-13
tr|:Q28403 (Q28403) Interleukin 6 (Fragment) 72 1e-12
tn|:AAM27192 (AAM27192) Interleukin-6 71 3e-12
sp|:IL6_FELCA (P41683) Interleukin-6 precursor (IL-6) 66 1e-10
tn|:AAK92044 (AAK92044) Interleukin-6 66 1e-10
scop|:d1alu__:a.26.1.1 (d1alu__:a.26.1.1) 65 2e-10
sp|:IL6_PHOVI (Q28819) Interleukin-6 precursor (IL-6) (Fragment 61 4e-09
tr|:Q9MZR1 (Q9MZR1) Interleukin 6 59 1e-08
sp|:IL6_BOVIN (P26892) Interleukin-6 precursor (IL-6) 54 3e-07
sp|:IL6_CAPHI (Q28319) Interleukin-6 precursor (IL-6) 53 7e-07
sp|:IL6_MARMO (O35736) Interleukin-6 precursor (IL-6) 52 1e-06
tr|:O97535 (O97535) Interleukin-6 (Fragment) 50 4e-06
tr|:Q9WVQ8 (Q9WVQ8) IL-6 (Fragment) 50 7e-06
sp|:IL6_MOUSE (P08505) Interleukin-6 precursor (IL-6) (Interleu 48 3e-05
tr|:Q9MZQ8 (Q9MZQ8) Interleukin 6 (Fragment)#tr|:Q9MZQ7 (Q9MZQ7)... 45 1e-04
tr|:Q9MZR0 (Q9MZR0) Interleukin 6 (Fragment) 43 0.001
sp|:IL6_MUSVI (P41693) Interleukin-6 (IL-6) (Fragment) 42 0.001
>scop|:d1bgc__:a.26.1.1 (d1bgc__:a.26.1.1)
Length = 165
Score = 253 bits (646), Expect = 4e-67
Identities = 154/165 (93%), Positives = 154/165 (93%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXX 60
SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP
Sbjct: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPLSSCSSQ 60
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
RGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA
Sbjct: 61 SLQLRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
Query: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA
Sbjct: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
>tr|:Q9GJU0 (Q9GJU0) Granulocyte colony-stimulating factor precu
Length = 195
Score = 247 bits (631), Expect = 3e-65
Identities = 128/163 (78%), Positives = 135/163 (82%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXX 60
SLPQSFLLKCLEQVRK+QADG LQERLCAAHKLCHPEEL+LL H+LGIPQAP
Sbjct: 29 SLPQSFLLKCLEQVRKVQADGTALQERLCAAHKLCHPEELVLLGHALGIPQAPLSSCSSQ 88
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
GCL QLH GLFLYQGLLQALAGISPELAPTLD LQLD+TDFA NIW QMED+G A
Sbjct: 89 ALQLTGCLRQLHSGLFLYQGLLQALAGISPELAPTLDMLQLDITDFAINIWQQMEDVGMA 148
Query: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRY 163
PAV PTQG MPTFTSAFQRRAGG LVAS L FLE+AYR LR+
Sbjct: 149 PAVPPTQGTMPTFTSAFQRRAGGTLVASNLQSFLEVAYRALRH 191
>sp|:CSF3_HUMAN (P09919) Granulocyte colony-stimulating factor p
Length = 207
Score = 242 bits (618), Expect = 7e-64
Identities = 126/168 (75%), Positives = 135/168 (80%), Gaps = 3/168 (1%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERL---CAAHKLCHPEELMLLRHSLGIPQAPXXXX 57
SLPQSFLLKCLEQVRKIQ DGA LQE+L CA +KLCHPEEL+LL HSLGIP AP
Sbjct: 38 SLPQSFLLKCLEQVRKIQGDGAALQEKLVSECATYKLCHPEELVLLGHSLGIPWAPLSSC 97
Query: 58 XXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDL 117
GCL+QLH GLFLYQGLLQAL GISPEL PTLDTLQLDV DFAT IW QME+L
Sbjct: 98 PSQALQLAGCLSQLHSGLFLYQGLLQALEGISPELGPTLDTLQLDVADFATTIWQQMEEL 157
Query: 118 GAAPAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
G APA+QPTQGAMP F SAFQRRAGGVLVAS L FLE++YR LR+LA
Sbjct: 158 GMAPALQPTQGAMPAFASAFQRRAGGVLVASHLQSFLEVSYRVLRHLA 205
>sp|:CSF3_PIG (O02837) Granulocyte colony-stimulating factor pre
Length = 195
Score = 236 bits (604), Expect = 3e-62
Identities = 133/165 (80%), Positives = 137/165 (82%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXX 60
SLPQSFLLKCLEQVRKIQADGAELQERLCA HKLCHP+EL+LL HSLG+PQA
Sbjct: 29 SLPQSFLLKCLEQVRKIQADGAELQERLCATHKLCHPQELVLLGHSLGLPQASLSSCSSQ 88
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
GCLNQLHGGL LYQGLLQALAGISPELAP LD LQLDVTD ATNIWLQMEDL A
Sbjct: 89 ALQLTGCLNQLHGGLVLYQGLLQALAGISPELAPALDILQLDVTDLATNIWLQMEDLRMA 148
Query: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
PA PTQG +PTFTSAFQRRAGGVLV SQL FLELAYR LRYLA
Sbjct: 149 PASLPTQGTVPTFTSAFQRRAGGVLVVSQLQSFLELAYRVLRYLA 193
>tr|:P97712 (P97712) Granulocyte colony stimulating factor
Length = 214
Score = 235 bits (601), Expect = 7e-62
Identities = 111/163 (68%), Positives = 120/163 (73%)
Query: 2 LPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXX 61
LP+SFLLK LEQVRKIQA EL E+LCA +KLCHPEEL+L HSLGIP+A
Sbjct: 36 LPRSFLLKSLEQVRKIQARNTELLEQLCATYKLCHPEELVLFGHSLGIPKASLSSCSSQA 95
Query: 62 XXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAP 121
CL+QLH GLFLYQGLLQALAGIS ELAPTLD L LDV +FAT IW QME LG AP
Sbjct: 96 LQQTKCLSQLHSGLFLYQGLLQALAGISSELAPTLDMLHLDVDNFATTIWQQMESLGVAP 155
Query: 122 AVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYL 164
VQPTQ MP FTSAFQRRAGGVLV S L FLE A+ L +L
Sbjct: 156 TVQPTQSTMPIFTSAFQRRAGGVLVTSYLQSFLETAHHALHHL 198
>sp|:CSF3_MOUSE (P09920) Granulocyte colony-stimulating factor p
Length = 208
Score = 226 bits (578), Expect = 4e-59
Identities = 112/164 (68%), Positives = 123/164 (74%)
Query: 2 LPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXX 61
LP+SFLLK LEQVRKIQA G+ L E+LCA +KLCHPEEL+LL HSLGIP+A
Sbjct: 45 LPRSFLLKSLEQVRKIQASGSVLLEQLCATYKLCHPEELVLLGHSLGIPKASLSGCSSQA 104
Query: 62 XXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAP 121
CL+QLH GL LYQGLLQAL+GISP LAPTLD LQLDV +FAT IW QME+LG AP
Sbjct: 105 LQQTQCLSQLHSGLCLYQGLLQALSGISPALAPTLDLLQLDVANFATTIWQQMENLGVAP 164
Query: 122 AVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
VQPTQ AMP FTSAFQRRAGGVL S L FLE A L +LA
Sbjct: 165 TVQPTQSAMPAFTSAFQRRAGGVLAISYLQGFLETARLALHHLA 208
>sp|:MGF_CHICK (P13854) Myelomonocytic growth factor precursor (
Length = 201
Score = 205 bits (523), Expect = 8e-53
Identities = 63/164 (38%), Positives = 84/164 (50%), Gaps = 2/164 (1%)
Query: 4 QSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXXXX 63
Q FL K LE RKI+ D A LQ +C +LC EEL L++ + QAP
Sbjct: 36 QLFLHKNLEFTRKIRGDVAALQRAVCDTFQLCTEEELQLVQPDPHLVQAPLDQCHKRGFQ 95
Query: 64 XRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAV 123
C Q+ GL Y L A+ + P ++TLQLD + ++NI QMEDLG
Sbjct: 96 AEVCFTQIRAGLHAYHDSLGAVLRLLPNHTTLVETLQLDAANLSSNIQQQMEDLGLDTVT 155
Query: 124 QPTQ--GAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
P + PTF+ FQ++ GG + + RFLE AYR LR+LA
Sbjct: 156 LPAEQRSPPPTFSGPFQQQVGGFFILANFQRFLETAYRALRHLA 199
>tr|:Q90YI0 (Q90YI0) Interleukin-6 precursor
Length = 241
Score = 196 bits (499), Expect = 5e-50
Identities = 34/165 (20%), Positives = 61/165 (36%), Gaps = 9/165 (5%)
Query: 7 LLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP-XXXXXXXXXXXR 65
LL C R ++ +LQ+ +C +C ML+R++L +P+
Sbjct: 71 LLDCEPLARVLRDRAVQLQDEMCKKFTVCENSMEMLVRNNLNLPKVTEEDGCLLAGFDEE 130
Query: 66 GCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQP 125
CL +L GLF +Q L+ + +++L A I + + V P
Sbjct: 131 KCLTKLSSGLFAFQTYLEFIQETFDSEKQNVESLCYSTKHLAATIRQMV--INPDEVVIP 188
Query: 126 TQGAMPTFTSAFQ------RRAGGVLVASQLHRFLELAYRGLRYL 164
A + + + + L+ F+E R +RYL
Sbjct: 189 DSAAQKSLLANLKSDKDWIEKITMHLILRDFTSFMEKTVRAVRYL 233
>tn|:AAM34205 (AAM34205) Granulocyte colony-stimulating factor
Length = 127
Score = 164 bits (415), Expect = 3e-40
Identities = 98/125 (78%), Positives = 99/125 (78%)
Query: 41 MLLRHSLGIPQAPXXXXXXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQ 100
MLL HSLGIPQ GCL+QLH GL LYQGLLQALAGISPELAPTLD LQ
Sbjct: 1 MLLGHSLGIPQPLLSSCSSQALQLTGCLSQLHSGLLLYQGLLQALAGISPELAPTLDMLQ 60
Query: 101 LDVTDFATNIWLQMEDLGAAPAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRG 160
LDVTDFATNIW QMEDLG AP VQPT G MPTF SAFQRRAGGVLVAS L RFLELAYRG
Sbjct: 61 LDVTDFATNIWQQMEDLGVAPVVQPTHGPMPTFASAFQRRAGGVLVASNLQRFLELAYRG 120
Query: 161 LRYLA 165
LRYLA
Sbjct: 121 LRYLA 125
>tr|:Q9XT80 (Q9XT80) Interleukin 6
Length = 208
Score = 81.3 bits (200), Expect = 2e-15
Identities = 27/162 (16%), Positives = 59/162 (35%), Gaps = 10/162 (6%)
Query: 9 KCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXXXXRGC 67
K ++ I + +++ +C + C + L ++L +P+ A C
Sbjct: 47 KTEALIKYILGKISAMRKEMCEKYDKCENSKEALAENNLNLPKMAEKDGCFQSGFNQETC 106
Query: 68 LNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQ 127
L ++ GL YQ L L +++ +Q+ + A + +++ P
Sbjct: 107 LMRITTGLLEYQIYLDYLQNEYEGDKGSIEAVQISIKALAQILRQKVK--NPDEVTTPDP 164
Query: 128 GAMPTFTSAFQ-------RRAGGVLVASQLHRFLELAYRGLR 162
+ + Q R +L+ L FL+ + R +R
Sbjct: 165 TTNASLMNNLQSQNDDWMRNTKIILILRSLENFLQFSLRAVR 206
>sp|:IL6_PIG (P26893) Interleukin-6 precursor (IL-6)
Length = 212
Score = 79.0 bits (194), Expect = 1e-14
Identities = 26/161 (16%), Positives = 57/161 (35%), Gaps = 9/161 (5%)
Query: 9 KCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXXXXRGC 67
K E ++ I + +++ +C ++ C + +L ++L +P+ A C
Sbjct: 52 KTEELIKYILGKISAMRKEMCEKYEKCENSKEVLAENNLNLPKMAEKDGCFQSGFNQETC 111
Query: 68 LNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQ 127
L ++ GL +Q L L ++ +Q+ + + + A P
Sbjct: 112 LMRITTGLVEFQIYLDYLQKEYESNKGNVEAVQISTKALIQTLRQKGK--NPDKATTPNP 169
Query: 128 GAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLR 162
Q + +L+ L FL+ + R +R
Sbjct: 170 TTNAGLLDKLQSQNEWMKNTKIILILRSLEDFLQFSLRAIR 210
>sp|:IL6_HORSE (Q95181) Interleukin-6 precursor (IL-6)
Length = 208
Score = 77.8 bits (191), Expect = 2e-14
Identities = 27/161 (16%), Positives = 57/161 (34%), Gaps = 10/161 (6%)
Query: 9 KCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXXXXRGC 67
K + ++ I + L+ +C C + +L ++L +P+ A C
Sbjct: 49 KTKQHIKYILGKISALKNEMCNNFSKCENSKEVLAENNLNLPKMAEKDGCFQSGFNQETC 108
Query: 68 LNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQ 127
L ++ GL +Q L+ L + T+Q+ + +M++ P
Sbjct: 109 LMKITTGLSEFQIYLEYLQNEFKGEKENIKTMQISTKVLVQILMQKMKN---PEVTTPDP 165
Query: 128 GAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLR 162
A + + + L+ L FL+ + R +R
Sbjct: 166 TAKSSLLAKLHSQNEWLKNTTTHLILRSLEDFLQFSLRAVR 206
>sp|:IL6_CANFA (P41323) Interleukin-6 precursor (IL-6)
Length = 207
Score = 75.2 bits (184), Expect = 2e-13
Identities = 27/169 (15%), Positives = 57/169 (32%), Gaps = 9/169 (5%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP-XXXXXX 59
SLP + K E ++ I + L++ +C C + L ++L +P+
Sbjct: 39 SLPLTSANKVEELIKYILGKISALRKEMCDKFNKCEDSKEALAENNLHLPKLEGKDGCFQ 98
Query: 60 XXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGA 119
CL ++ GL +Q L L + ++ + + +++
Sbjct: 99 SGFNQETCLTRITTGLVEFQLHLNILQNNYEGDKENVKSVHMSTKILVQMLKSKVK--NQ 156
Query: 120 APAVQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLR 162
P + + Q + L+ L FL+ + R +R
Sbjct: 157 DEVTTPDPTTDASLQAILQSQDECVKHTTIHLILRSLEDFLQFSLRAVR 205
>tr|:Q28403 (Q28403) Interleukin 6 (Fragment)
Length = 207
Score = 72.5 bits (177), Expect = 1e-12
Identities = 24/161 (14%), Positives = 54/161 (32%), Gaps = 11/161 (6%)
Query: 9 KCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXXXXRGC 67
K + ++ I + L+ +C + C + +L ++L +P+ A C
Sbjct: 49 KMEDFIKFILGKISALRNEMCDKYNKCEDSKEVLAENNLNLPKLAEKDRCFQSRFNQETC 108
Query: 68 LNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQ 127
L ++ GL +Q L+ L ++ + + P
Sbjct: 109 LTRITTGLQEFQIHLKYLESNYEGNKDNAHSVYISTKHLLQTLRPM----NQIEVTTPDP 164
Query: 128 GAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLR 162
+ + F+ + L+ +L FL+ + R +R
Sbjct: 165 TTDASLQALFKSQDKWLKHTTIHLILRRLEDFLQFSLRAIR 205
>tn|:AAM27192 (AAM27192) Interleukin-6
Length = 214
Score = 70.9 bits (173), Expect = 3e-12
Identities = 20/133 (15%), Positives = 46/133 (34%), Gaps = 3/133 (2%)
Query: 9 KCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXXXXRGC 67
K E ++ I + +++ +C ++ C + +L ++L +P+ A C
Sbjct: 52 KTEELIKYILGKISAMRKEMCEKYEKCENSKEVLAENNLNLPKMAEKDGCFQSGFNQETC 111
Query: 68 LNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQ 127
L ++ GL +Q L L ++ +Q+ + + + A P
Sbjct: 112 LMRITTGLVEFQIYLDYLQKEYESNKGNVEAVQISTKALIQTLRQKGK--NPDKATTPNP 169
Query: 128 GAMPTFTSAFQRR 140
Q +
Sbjct: 170 TTNAGLLDKLQSQ 182
>sp|:IL6_FELCA (P41683) Interleukin-6 precursor (IL-6)
Length = 208
Score = 65.9 bits (160), Expect = 1e-10
Identities = 33/171 (19%), Positives = 60/171 (34%), Gaps = 15/171 (8%)
Query: 2 LPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXX 60
LP + K E ++ I + L++ +C + C + L ++L +P+ A
Sbjct: 41 LPLTSADKMEELIKYILGKISALKKEMCDNYNKCEDSKEALAENNLNLPKLAEKDGCFQS 100
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQM---EDL 117
CL ++ GL +Q L+ L ++ +TN+ LQM +
Sbjct: 101 GFNQETCLTRITTGLQEFQIYLKFLQDKYEGDEENAKSV-----YTSTNVLLQMLKRKGK 155
Query: 118 GAAPAVQPTQGAMPTFTSAFQ------RRAGGVLVASQLHRFLELAYRGLR 162
P + Q R L +L FL+ + R +R
Sbjct: 156 NQDEVTIPVPTVEVGLQAKLQSQEEWLRHTTIHLTLRRLEDFLQFSLRAVR 206
>tn|:AAK92044 (AAK92044) Interleukin-6
Length = 212
Score = 65.5 bits (159), Expect = 1e-10
Identities = 30/173 (17%), Positives = 61/173 (34%), Gaps = 13/173 (7%)
Query: 3 PQSFLLKCLEQVRK----IQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXX 57
P LL E++ K I + L++ +C +C + L ++L +P+ A
Sbjct: 42 PNRQLLTSTERIDKHIWYILDGISALRKEICNKSNMCESSKEALAENNLNLPKMAEKDGC 101
Query: 58 XXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDL 117
CL ++ GL ++ L+ L +Q+ ++ + ++L
Sbjct: 102 FQSGFNEETCLLKITTGLLEFEVYLEYLQNRFESSKEQAGAVQMSTKGLIQSLQRKAKNL 161
Query: 118 GAAPAVQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
A P + + Q + L+ FL+ + R LR +
Sbjct: 162 SA--IATPDPATNASLLTKLQAQDQWLQGVTTHLILRSFKEFLQCSLRALRQM 212
>scop|:d1alu__:a.26.1.1 (d1alu__:a.26.1.1)
Length = 166
Score = 65.1 bits (158), Expect = 2e-10
Identities = 26/159 (16%), Positives = 54/159 (33%), Gaps = 9/159 (5%)
Query: 13 QVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXXXXRGCLNQL 71
Q+R I + L++ C +C + L ++L +P+ A CL ++
Sbjct: 10 QIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKI 69
Query: 72 HGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQGAMP 131
GL ++ L+ L +Q+ + + ++L P
Sbjct: 70 ITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNL--DAITTPDPTTNA 127
Query: 132 TFTSAFQ------RRAGGVLVASQLHRFLELAYRGLRYL 164
+ + Q + L+ FL+ + R LR +
Sbjct: 128 SLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM 166
>sp|:IL6_PHOVI (Q28819) Interleukin-6 precursor (IL-6) (Fragment
Length = 209
Score = 60.5 bits (146), Expect = 4e-09
Identities = 23/161 (14%), Positives = 56/161 (34%), Gaps = 9/161 (5%)
Query: 9 KCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXXXXRGC 67
K E ++ I + L++ +C + C + L ++L +P+ A C
Sbjct: 49 KMEEFIKYILGKISALRKEMCDKYNKCEDSKEALAENNLRLPKLAEKDGCFQSGFNQETC 108
Query: 68 LNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQ 127
L ++ GL +Q L+ + +++ + + +++ P
Sbjct: 109 LTRITTGLLEFQIHLKYIQANYEGNKEDANSVYISTKLLVQMLMKKVKS--QDEVTTPDP 166
Query: 128 GAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLR 162
+ + + + L+ L FL+ + R +R
Sbjct: 167 TTDTSLQAILKAQDKWLKHTTIHLILRSLEDFLQFSLRAVR 207
>tr|:Q9MZR1 (Q9MZR1) Interleukin 6
Length = 241
Score = 59.0 bits (142), Expect = 1e-08
Identities = 26/159 (16%), Positives = 55/159 (34%), Gaps = 11/159 (6%)
Query: 12 EQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXXXXRGCLNQ 70
E +R I EL++ +C C + L +L +P+ CL +
Sbjct: 55 ESIRSILETIKELRKEMCDHDVNCMNRKEALAEVNLHLPRLIEEDGCFPPAVNNETCLLR 114
Query: 71 LHGGLFLYQGLLQALAGI--SPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQG 128
+ GL ++ L+ L S E + + ++ + ++++L ++P
Sbjct: 115 ITSGLMEFRMYLEHLQAKFRSDEENTRVSMVLKNIQHLIKTLRPKVKNLNEEATLKPAVA 174
Query: 129 AMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGL 161
+ Q++ + L FLE R +
Sbjct: 175 V--SLMENLQQKNQWLKTTTIHFILRGLTNFLEFTLRAV 211
>sp|:IL6_BOVIN (P26892) Interleukin-6 precursor (IL-6)
Length = 208
Score = 54.4 bits (130), Expect = 3e-07
Identities = 26/155 (16%), Positives = 58/155 (36%), Gaps = 1/155 (0%)
Query: 9 KCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXXXXXRG-C 67
K ++++ + +++ +C + C + L + L +P+ + C
Sbjct: 52 KTEALIKRMVDKISAMRKEICEKNDECESSKETLAENKLNLPKMEEKDGCFQSGFNQAIC 111
Query: 68 LNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQ 127
L + GL YQ L L + L+ ++ + ++ DL PA
Sbjct: 112 LIRTTAGLLEYQIYLDYLQNEYEGNQENVRDLRKNIRTLIQILKQKIADLITTPATNTDL 171
Query: 128 GAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLR 162
++ + + A +L+ L FL+ + R +R
Sbjct: 172 LEKMQSSNEWVKNAKIILILRNLENFLQFSLRAIR 206
>sp|:IL6_CAPHI (Q28319) Interleukin-6 precursor (IL-6)
Length = 208
Score = 53.2 bits (127), Expect = 7e-07
Identities = 27/155 (17%), Positives = 56/155 (35%), Gaps = 1/155 (0%)
Query: 9 KCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXXXXXRG-C 67
K ++ I + +++ +C + C + L + L +P+ + C
Sbjct: 52 KTEALIKHIVDKISAIRKEICEKNDECENSKETLAENKLKLPKMEEKDGCFQSGFNQAIC 111
Query: 68 LNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQ 127
L + GL YQ L L T+ LQ + + ++ L PA
Sbjct: 112 LIKTTAGLLEYQIYLDFLQNEFEGNQETVMELQSSIRTLIQILKEKIAGLITTPATNTDM 171
Query: 128 GAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLR 162
++ + + A +++ L FL+ + R +R
Sbjct: 172 LEKMQSSNEWVKNAKVIIILRSLENFLQFSLRAIR 206
>sp|:IL6_MARMO (O35736) Interleukin-6 precursor (IL-6)
Length = 207
Score = 52.4 bits (125), Expect = 1e-06
Identities = 26/149 (17%), Positives = 53/149 (35%), Gaps = 11/149 (7%)
Query: 23 ELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXXXXXR-GCLNQLHGGLFLYQGL 81
E+++ LC + C + + ++L +P+ R CL ++ GL +Q
Sbjct: 59 EMRKELCKNDETCIKSHVAVSENNLNLPKMTEKDGCFQTGYNRDDCLVRITSGLLEFQVY 118
Query: 82 LQALAGISPE--LAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQGAMPTFTSAF-- 137
L+ + E + +Q + +++D V P+ A +
Sbjct: 119 LRYIRNKFQEGNNRDRAEHVQSSSKALIEILKQEVKD--PNKIVFPSPTANINLLAKLES 176
Query: 138 ----QRRAGGVLVASQLHRFLELAYRGLR 162
Q+ L+ S FL+ R +R
Sbjct: 177 QNDWQKVMTMQLILSNFEDFLQFTLRAVR 205
>tr|:O97535 (O97535) Interleukin-6 (Fragment)
Length = 160
Score = 50.5 bits (120), Expect = 4e-06
Identities = 22/111 (19%), Positives = 42/111 (37%), Gaps = 5/111 (4%)
Query: 3 PQSFLLKCLEQ----VRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXX 57
P LL EQ +R I A L++ +C +C + L ++L +P+ A
Sbjct: 42 PNRQLLTSTEQIDKHIRYILEGIAALRKEICDKSNMCESSKEALAENNLNLPKMAEKDGC 101
Query: 58 XXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFAT 108
CL ++ GL ++ L+ L +Q+ +++
Sbjct: 102 FQSGFNEETCLLKITTGLLEFEVYLEYLQNRFESSKEQAGAVQMSTKAWSS 152
>tr|:Q9WVQ8 (Q9WVQ8) IL-6 (Fragment)
Length = 210
Score = 49.7 bits (118), Expect = 7e-06
Identities = 28/148 (18%), Positives = 52/148 (34%), Gaps = 10/148 (6%)
Query: 23 ELQERLCAAHKLCHPEELMLLRHSLGIPQAP-XXXXXXXXXXXRGCLNQLHGGLFLYQGL 81
EL++ LC + C + +LL ++L +P CL ++ GL YQ
Sbjct: 63 ELRKELCNNNPGCMDNDYVLLENNLELPVIQINDGCLQTGYNWEICLLKITSGLLDYQIY 122
Query: 82 LQALA-GISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQGAMPTFTSAFQ-- 138
L+ + + +Q + + +++ G V P+ + +
Sbjct: 123 LEFVTNNVQDNKKDKARVIQSTIKTLSQIFKQEVK--GPDKIVTPSPTSKAILMEKLESQ 180
Query: 139 ----RRAGGVLVASQLHRFLELAYRGLR 162
R L+ L FLE+ R R
Sbjct: 181 KEWPRTKTIKLILKALEEFLEVTMRSTR 208
>sp|:IL6_MOUSE (P08505) Interleukin-6 precursor (IL-6) (Interleu
Length = 211
Score = 47.8 bits (113), Expect = 3e-05
Identities = 28/149 (18%), Positives = 50/149 (32%), Gaps = 10/149 (6%)
Query: 22 AELQERLCAAHKLCHPEELMLLRHSLGIPQAP-XXXXXXXXXXXRGCLNQLHGGLFLYQG 80
E+++ LC + C + L ++L +P+ CL ++ GL Y
Sbjct: 63 VEMRKELCNGNSDCMNNDDALAENNLKLPEIQRNDGCYQTGYNQEICLLKISSGLLEYHS 122
Query: 81 LLQALA-GISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQGAMPTFTSAFQ- 138
L+ + + LQ D +++DL V PT + T +
Sbjct: 123 YLEYMKNNLKDNKKDKARVLQRDTETLIHIFNQEVKDLH--KIVLPTPISNALLTDKLES 180
Query: 139 -----RRAGGVLVASQLHRFLELAYRGLR 162
R + L FL++ R R
Sbjct: 181 QKEWLRTKTIQFILKSLEEFLKVTLRSTR 209
>tr|:Q9MZQ8 (Q9MZQ8) Interleukin 6 (Fragment)#tr|:Q9MZQ7 (Q9MZQ7)
Interleukin 6 (Fragment)
Length = 118
Score = 45.5 bits (107), Expect = 1e-04
Identities = 17/105 (16%), Positives = 39/105 (36%), Gaps = 10/105 (9%)
Query: 65 RGCLNQLHGGLFLYQGLLQALAGI--SPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPA 122
CL ++ GL +Q L+ L S E + + ++ + ++++L
Sbjct: 13 ETCLLRITSGLLEFQMYLEHLQAKFRSDEENTRVSMMLKNIRYLIKTLRPKVKNLNEGAT 72
Query: 123 VQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGL 161
++P A + Q++ + L FL+ + R +
Sbjct: 73 LKPAIVA--SLMKNLQQKDQWLKTTTIHFILRNLTDFLQFSLRAV 115
>tr|:Q9MZR0 (Q9MZR0) Interleukin 6 (Fragment)
Length = 118
Score = 42.8 bits (100), Expect = 0.001
Identities = 16/106 (15%), Positives = 38/106 (35%), Gaps = 10/106 (9%)
Query: 65 RGCLNQLHGGLFLYQGLLQALAGI--SPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPA 122
CL ++ GL +Q L+ L S E + + ++ + ++++
Sbjct: 13 ETCLLRITSGLLEFQMYLEHLQAKFRSEEENTRVSMILKNMRHLINTLRPKVKNFNEGAT 72
Query: 123 VQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLR 162
++P + + Q++ + L FL+ R +R
Sbjct: 73 LKP--AVVASLMENLQQKDQWLKTTTIHFILRGLTDFLQFTLRSVR 116
>sp|:IL6_MUSVI (P41693) Interleukin-6 (IL-6) (Fragment)
Length = 125
Score = 42.4 bits (99), Expect = 0.001
Identities = 17/125 (13%), Positives = 40/125 (31%), Gaps = 11/125 (8%)
Query: 45 HSLGIPQ-APXXXXXXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDV 103
++L +P+ A C+ ++ GL +Q L+ L ++ +
Sbjct: 3 NNLKLPKLAEKDKCFQSQFNQETCMTRITTGLQEFQIHLKYLEANYEGNKNNAHSVYIST 62
Query: 104 TDFATNIWLQMEDLGAAPAVQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELA 157
++ + P + + F+ + L+ L FL+ +
Sbjct: 63 KHLL----QKLRPMNQVEVTTPNPTTDSSLQALFKSQDKWLKHVTIHLILRSLEDFLQFS 118
Query: 158 YRGLR 162
R +R
Sbjct: 119 LRAIR 123
Searching..................................................done
Results from round 4
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
tr|:Q9XT80 (Q9XT80) Interleukin 6 214 2e-55
sp|:IL6_CANFA (P41323) Interleukin-6 precursor (IL-6) 213 4e-55
sp|:IL6_PIG (P26893) Interleukin-6 precursor (IL-6) 209 6e-54
scop|:d1bgc__:a.26.1.1 (d1bgc__:a.26.1.1) 209 7e-54
tr|:Q28403 (Q28403) Interleukin 6 (Fragment) 209 7e-54
sp|:CSF3_HUMAN (P09919) Granulocyte colony-stimulating factor p 207 2e-53
tr|:Q9GJU0 (Q9GJU0) Granulocyte colony-stimulating factor precu 207 2e-53
sp|:IL6_FELCA (P41683) Interleukin-6 precursor (IL-6) 201 2e-51
sp|:CSF3_PIG (O02837) Granulocyte colony-stimulating factor pre 199 6e-51
sp|:IL6_HORSE (Q95181) Interleukin-6 precursor (IL-6) 195 1e-49
sp|:IL6_PHOVI (Q28819) Interleukin-6 precursor (IL-6) (Fragment 194 3e-49
tr|:P97712 (P97712) Granulocyte colony stimulating factor 192 5e-49
sp|:CSF3_MOUSE (P09920) Granulocyte colony-stimulating factor p 190 2e-48
tn|:AAK92044 (AAK92044) Interleukin-6 189 7e-48
tn|:AAM27192 (AAM27192) Interleukin-6 184 2e-46
sp|:IL6_BOVIN (P26892) Interleukin-6 precursor (IL-6) 183 4e-46
scop|:d1alu__:a.26.1.1 (d1alu__:a.26.1.1) 179 7e-45
sp|:MGF_CHICK (P13854) Myelomonocytic growth factor precursor ( 177 2e-44
sp|:IL6_CAPHI (Q28319) Interleukin-6 precursor (IL-6) 177 3e-44
tr|:Q90YI0 (Q90YI0) Interleukin-6 precursor 174 2e-43
tr|:Q9MZR1 (Q9MZR1) Interleukin 6 166 5e-41
sp|:IL6_MARMO (O35736) Interleukin-6 precursor (IL-6) 159 8e-39
tr|:Q9WVQ8 (Q9WVQ8) IL-6 (Fragment) 153 4e-37
sp|:IL6_MOUSE (P08505) Interleukin-6 precursor (IL-6) (Interleu 150 2e-36
tr|:O97535 (O97535) Interleukin-6 (Fragment) 135 1e-31
sp|:IL6_MUSVI (P41693) Interleukin-6 (IL-6) (Fragment) 134 2e-31
tn|:AAM34205 (AAM34205) Granulocyte colony-stimulating factor 129 7e-30
tr|:Q9MZR0 (Q9MZR0) Interleukin 6 (Fragment) 113 3e-25
tr|:Q9MZQ8 (Q9MZQ8) Interleukin 6 (Fragment)#tr|:Q9MZQ7 (Q9MZQ7)... 113 6e-25
Sequences not found previously or not previously below threshold:
sp|:IL6_RAT (P20607) Interleukin-6 precursor (IL-6) 138 1e-32
tr|:Q91ZL3 (Q91ZL3) Interleukin 6 135 1e-31
tr|:Q8SPS3 (Q8SPS3) Interleukin-6 (Fragment) 69 1e-11
>tr|:Q9XT80 (Q9XT80) Interleukin 6
Length = 208
Score = 214 bits (545), Expect = 2e-55
Identities = 28/169 (16%), Positives = 61/169 (35%), Gaps = 10/169 (5%)
Query: 2 LPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXX 60
L + K ++ I + +++ +C + C + L ++L +P+ A
Sbjct: 40 LLLTSPDKTEALIKYILGKISAMRKEMCEKYDKCENSKEALAENNLNLPKMAEKDGCFQS 99
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
CL ++ GL YQ L L +++ +Q+ + A + +++
Sbjct: 100 GFNQETCLMRITTGLLEYQIYLDYLQNEYEGDKGSIEAVQISIKALAQILRQKVK--NPD 157
Query: 121 PAVQPTQGAMPTFTSAFQ-------RRAGGVLVASQLHRFLELAYRGLR 162
P + + Q R +L+ L FL+ + R +R
Sbjct: 158 EVTTPDPTTNASLMNNLQSQNDDWMRNTKIILILRSLENFLQFSLRAVR 206
>sp|:IL6_CANFA (P41323) Interleukin-6 precursor (IL-6)
Length = 207
Score = 213 bits (543), Expect = 4e-55
Identities = 27/171 (15%), Positives = 58/171 (33%), Gaps = 9/171 (5%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP-XXXXXX 59
SLP + K E ++ I + L++ +C C + L ++L +P+
Sbjct: 39 SLPLTSANKVEELIKYILGKISALRKEMCDKFNKCEDSKEALAENNLHLPKLEGKDGCFQ 98
Query: 60 XXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGA 119
CL ++ GL +Q L L + ++ + + +++
Sbjct: 99 SGFNQETCLTRITTGLVEFQLHLNILQNNYEGDKENVKSVHMSTKILVQMLKSKVK--NQ 156
Query: 120 APAVQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
P + + Q + L+ L FL+ + R +R +
Sbjct: 157 DEVTTPDPTTDASLQAILQSQDECVKHTTIHLILRSLEDFLQFSLRAVRIM 207
>sp|:IL6_PIG (P26893) Interleukin-6 precursor (IL-6)
Length = 212
Score = 209 bits (533), Expect = 6e-54
Identities = 26/167 (15%), Positives = 59/167 (34%), Gaps = 9/167 (5%)
Query: 5 SFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXXX 63
+ K E ++ I + +++ +C ++ C + +L ++L +P+ A
Sbjct: 48 TSPDKTEELIKYILGKISAMRKEMCEKYEKCENSKEVLAENNLNLPKMAEKDGCFQSGFN 107
Query: 64 XRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAV 123
CL ++ GL +Q L L ++ +Q+ + + + A
Sbjct: 108 QETCLMRITTGLVEFQIYLDYLQKEYESNKGNVEAVQISTKALIQTLRQKGK--NPDKAT 165
Query: 124 QPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
P Q + +L+ L FL+ + R +R +
Sbjct: 166 TPNPTTNAGLLDKLQSQNEWMKNTKIILILRSLEDFLQFSLRAIRIM 212
>scop|:d1bgc__:a.26.1.1 (d1bgc__:a.26.1.1)
Length = 165
Score = 209 bits (532), Expect = 7e-54
Identities = 154/165 (93%), Positives = 154/165 (93%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXX 60
SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP
Sbjct: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPLSSCSSQ 60
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
RGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA
Sbjct: 61 SLQLRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
Query: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA
Sbjct: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
>tr|:Q28403 (Q28403) Interleukin 6 (Fragment)
Length = 207
Score = 209 bits (532), Expect = 7e-54
Identities = 25/169 (14%), Positives = 58/169 (33%), Gaps = 11/169 (6%)
Query: 3 PQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXX 61
P + K + ++ I + L+ +C + C + +L ++L +P+ A
Sbjct: 43 PLTSADKMEDFIKFILGKISALRNEMCDKYNKCEDSKEVLAENNLNLPKLAEKDRCFQSR 102
Query: 62 XXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAP 121
CL ++ GL +Q L+ L ++ + + +
Sbjct: 103 FNQETCLTRITTGLQEFQIHLKYLESNYEGNKDNAHSVYISTKHLLQTLRP----MNQIE 158
Query: 122 AVQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
P + + F+ + L+ +L FL+ + R +R +
Sbjct: 159 VTTPDPTTDASLQALFKSQDKWLKHTTIHLILRRLEDFLQFSLRAIRIM 207
>sp|:CSF3_HUMAN (P09919) Granulocyte colony-stimulating factor p
Length = 207
Score = 207 bits (529), Expect = 2e-53
Identities = 126/168 (75%), Positives = 135/168 (80%), Gaps = 3/168 (1%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERL---CAAHKLCHPEELMLLRHSLGIPQAPXXXX 57
SLPQSFLLKCLEQVRKIQ DGA LQE+L CA +KLCHPEEL+LL HSLGIP AP
Sbjct: 38 SLPQSFLLKCLEQVRKIQGDGAALQEKLVSECATYKLCHPEELVLLGHSLGIPWAPLSSC 97
Query: 58 XXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDL 117
GCL+QLH GLFLYQGLLQAL GISPEL PTLDTLQLDV DFAT IW QME+L
Sbjct: 98 PSQALQLAGCLSQLHSGLFLYQGLLQALEGISPELGPTLDTLQLDVADFATTIWQQMEEL 157
Query: 118 GAAPAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
G APA+QPTQGAMP F SAFQRRAGGVLVAS L FLE++YR LR+LA
Sbjct: 158 GMAPALQPTQGAMPAFASAFQRRAGGVLVASHLQSFLEVSYRVLRHLA 205
>tr|:Q9GJU0 (Q9GJU0) Granulocyte colony-stimulating factor precu
Length = 195
Score = 207 bits (528), Expect = 2e-53
Identities = 128/163 (78%), Positives = 135/163 (82%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXX 60
SLPQSFLLKCLEQVRK+QADG LQERLCAAHKLCHPEEL+LL H+LGIPQAP
Sbjct: 29 SLPQSFLLKCLEQVRKVQADGTALQERLCAAHKLCHPEELVLLGHALGIPQAPLSSCSSQ 88
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
GCL QLH GLFLYQGLLQALAGISPELAPTLD LQLD+TDFA NIW QMED+G A
Sbjct: 89 ALQLTGCLRQLHSGLFLYQGLLQALAGISPELAPTLDMLQLDITDFAINIWQQMEDVGMA 148
Query: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRY 163
PAV PTQG MPTFTSAFQRRAGG LVAS L FLE+AYR LR+
Sbjct: 149 PAVPPTQGTMPTFTSAFQRRAGGTLVASNLQSFLEVAYRALRH 191
>sp|:IL6_FELCA (P41683) Interleukin-6 precursor (IL-6)
Length = 208
Score = 201 bits (512), Expect = 2e-51
Identities = 28/170 (16%), Positives = 56/170 (32%), Gaps = 9/170 (5%)
Query: 2 LPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXX 60
LP + K E ++ I + L++ +C + C + L ++L +P+ A
Sbjct: 41 LPLTSADKMEELIKYILGKISALKKEMCDNYNKCEDSKEALAENNLNLPKLAEKDGCFQS 100
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
CL ++ GL +Q L+ L ++ + + +
Sbjct: 101 GFNQETCLTRITTGLQEFQIYLKFLQDKYEGDEENAKSVYTSTNVLLQMLKRKGK--NQD 158
Query: 121 PAVQPTQGAMPTFTSAFQ------RRAGGVLVASQLHRFLELAYRGLRYL 164
P + Q R L +L FL+ + R +R +
Sbjct: 159 EVTIPVPTVEVGLQAKLQSQEEWLRHTTIHLTLRRLEDFLQFSLRAVRIM 208
>sp|:CSF3_PIG (O02837) Granulocyte colony-stimulating factor pre
Length = 195
Score = 199 bits (507), Expect = 6e-51
Identities = 133/165 (80%), Positives = 137/165 (82%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXX 60
SLPQSFLLKCLEQVRKIQADGAELQERLCA HKLCHP+EL+LL HSLG+PQA
Sbjct: 29 SLPQSFLLKCLEQVRKIQADGAELQERLCATHKLCHPQELVLLGHSLGLPQASLSSCSSQ 88
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
GCLNQLHGGL LYQGLLQALAGISPELAP LD LQLDVTD ATNIWLQMEDL A
Sbjct: 89 ALQLTGCLNQLHGGLVLYQGLLQALAGISPELAPALDILQLDVTDLATNIWLQMEDLRMA 148
Query: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
PA PTQG +PTFTSAFQRRAGGVLV SQL FLELAYR LRYLA
Sbjct: 149 PASLPTQGTVPTFTSAFQRRAGGVLVVSQLQSFLELAYRVLRYLA 193
>sp|:IL6_HORSE (Q95181) Interleukin-6 precursor (IL-6)
Length = 208
Score = 195 bits (496), Expect = 1e-49
Identities = 27/168 (16%), Positives = 59/168 (35%), Gaps = 10/168 (5%)
Query: 4 QSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXX 62
+ K + ++ I + L+ +C C + +L ++L +P+ A
Sbjct: 44 LTTADKTKQHIKYILGKISALKNEMCNNFSKCENSKEVLAENNLNLPKMAEKDGCFQSGF 103
Query: 63 XXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPA 122
CL ++ GL +Q L+ L + T+Q+ + +M++
Sbjct: 104 NQETCLMKITTGLSEFQIYLEYLQNEFKGEKENIKTMQISTKVLVQILMQKMKN---PEV 160
Query: 123 VQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
P A + + + L+ L FL+ + R +R +
Sbjct: 161 TTPDPTAKSSLLAKLHSQNEWLKNTTTHLILRSLEDFLQFSLRAVRIM 208
>sp|:IL6_PHOVI (Q28819) Interleukin-6 precursor (IL-6) (Fragment
Length = 209
Score = 194 bits (493), Expect = 3e-49
Identities = 24/169 (14%), Positives = 59/169 (34%), Gaps = 9/169 (5%)
Query: 3 PQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXX 61
P + K E ++ I + L++ +C + C + L ++L +P+ A
Sbjct: 43 PLTSPDKMEEFIKYILGKISALRKEMCDKYNKCEDSKEALAENNLRLPKLAEKDGCFQSG 102
Query: 62 XXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAP 121
CL ++ GL +Q L+ + +++ + + +++
Sbjct: 103 FNQETCLTRITTGLLEFQIHLKYIQANYEGNKEDANSVYISTKLLVQMLMKKVKS--QDE 160
Query: 122 AVQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
P + + + + L+ L FL+ + R +R +
Sbjct: 161 VTTPDPTTDTSLQAILKAQDKWLKHTTIHLILRSLEDFLQFSLRAVRIM 209
>tr|:P97712 (P97712) Granulocyte colony stimulating factor
Length = 214
Score = 192 bits (490), Expect = 5e-49
Identities = 111/163 (68%), Positives = 120/163 (73%)
Query: 2 LPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXX 61
LP+SFLLK LEQVRKIQA EL E+LCA +KLCHPEEL+L HSLGIP+A
Sbjct: 36 LPRSFLLKSLEQVRKIQARNTELLEQLCATYKLCHPEELVLFGHSLGIPKASLSSCSSQA 95
Query: 62 XXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAP 121
CL+QLH GLFLYQGLLQALAGIS ELAPTLD L LDV +FAT IW QME LG AP
Sbjct: 96 LQQTKCLSQLHSGLFLYQGLLQALAGISSELAPTLDMLHLDVDNFATTIWQQMESLGVAP 155
Query: 122 AVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYL 164
VQPTQ MP FTSAFQRRAGGVLV S L FLE A+ L +L
Sbjct: 156 TVQPTQSTMPIFTSAFQRRAGGVLVTSYLQSFLETAHHALHHL 198
>sp|:CSF3_MOUSE (P09920) Granulocyte colony-stimulating factor p
Length = 208
Score = 190 bits (485), Expect = 2e-48
Identities = 112/164 (68%), Positives = 123/164 (74%)
Query: 2 LPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXX 61
LP+SFLLK LEQVRKIQA G+ L E+LCA +KLCHPEEL+LL HSLGIP+A
Sbjct: 45 LPRSFLLKSLEQVRKIQASGSVLLEQLCATYKLCHPEELVLLGHSLGIPKASLSGCSSQA 104
Query: 62 XXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAP 121
CL+QLH GL LYQGLLQAL+GISP LAPTLD LQLDV +FAT IW QME+LG AP
Sbjct: 105 LQQTQCLSQLHSGLCLYQGLLQALSGISPALAPTLDLLQLDVANFATTIWQQMENLGVAP 164
Query: 122 AVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
VQPTQ AMP FTSAFQRRAGGVL S L FLE A L +LA
Sbjct: 165 TVQPTQSAMPAFTSAFQRRAGGVLAISYLQGFLETARLALHHLA 208
>tn|:AAK92044 (AAK92044) Interleukin-6
Length = 212
Score = 189 bits (480), Expect = 7e-48
Identities = 28/173 (16%), Positives = 59/173 (33%), Gaps = 13/173 (7%)
Query: 3 PQSFLLKCLEQVR----KIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXX 57
P LL E++ I + L++ +C +C + L ++L +P+ A
Sbjct: 42 PNRQLLTSTERIDKHIWYILDGISALRKEICNKSNMCESSKEALAENNLNLPKMAEKDGC 101
Query: 58 XXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDL 117
CL ++ GL ++ L+ L +Q+ ++ + ++L
Sbjct: 102 FQSGFNEETCLLKITTGLLEFEVYLEYLQNRFESSKEQAGAVQMSTKGLIQSLQRKAKNL 161
Query: 118 GAAPAVQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
P + + Q + L+ FL+ + R LR +
Sbjct: 162 S--AIATPDPATNASLLTKLQAQDQWLQGVTTHLILRSFKEFLQCSLRALRQM 212
>tn|:AAM27192 (AAM27192) Interleukin-6
Length = 214
Score = 184 bits (468), Expect = 2e-46
Identities = 20/137 (14%), Positives = 47/137 (33%), Gaps = 3/137 (2%)
Query: 5 SFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXXX 63
+ K E ++ I + +++ +C ++ C + +L ++L +P+ A
Sbjct: 48 TSPDKTEELIKYILGKISAMRKEMCEKYEKCENSKEVLAENNLNLPKMAEKDGCFQSGFN 107
Query: 64 XRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAV 123
CL ++ GL +Q L L ++ +Q+ + + + A
Sbjct: 108 QETCLMRITTGLVEFQIYLDYLQKEYESNKGNVEAVQISTKALIQTLRQKGK--NPDKAT 165
Query: 124 QPTQGAMPTFTSAFQRR 140
P Q +
Sbjct: 166 TPNPTTNAGLLDKLQSQ 182
>sp|:IL6_BOVIN (P26892) Interleukin-6 precursor (IL-6)
Length = 208
Score = 183 bits (465), Expect = 4e-46
Identities = 29/165 (17%), Positives = 61/165 (36%), Gaps = 5/165 (3%)
Query: 3 PQSFLL----KCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXX 58
P LL K ++++ + +++ +C + C + L + L +P+
Sbjct: 42 PGRLLLTTPEKTEALIKRMVDKISAMRKEICEKNDECESSKETLAENKLNLPKMEEKDGC 101
Query: 59 XXXXXXR-GCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDL 117
+ CL + GL YQ L L + L+ ++ + ++ DL
Sbjct: 102 FQSGFNQAICLIRTTAGLLEYQIYLDYLQNEYEGNQENVRDLRKNIRTLIQILKQKIADL 161
Query: 118 GAAPAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLR 162
PA ++ + + A +L+ L FL+ + R +R
Sbjct: 162 ITTPATNTDLLEKMQSSNEWVKNAKIILILRNLENFLQFSLRAIR 206
>scop|:d1alu__:a.26.1.1 (d1alu__:a.26.1.1)
Length = 166
Score = 179 bits (454), Expect = 7e-45
Identities = 26/159 (16%), Positives = 54/159 (33%), Gaps = 9/159 (5%)
Query: 13 QVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXXXXRGCLNQL 71
Q+R I + L++ C +C + L ++L +P+ A CL ++
Sbjct: 10 QIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKI 69
Query: 72 HGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQGAMP 131
GL ++ L+ L +Q+ + + ++L P
Sbjct: 70 ITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNL--DAITTPDPTTNA 127
Query: 132 TFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
+ + Q + L+ FL+ + R LR +
Sbjct: 128 SLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM 166
>sp|:MGF_CHICK (P13854) Myelomonocytic growth factor precursor (
Length = 201
Score = 177 bits (451), Expect = 2e-44
Identities = 63/164 (38%), Positives = 84/164 (50%), Gaps = 2/164 (1%)
Query: 4 QSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXXXX 63
Q FL K LE RKI+ D A LQ +C +LC EEL L++ + QAP
Sbjct: 36 QLFLHKNLEFTRKIRGDVAALQRAVCDTFQLCTEEELQLVQPDPHLVQAPLDQCHKRGFQ 95
Query: 64 XRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAV 123
C Q+ GL Y L A+ + P ++TLQLD + ++NI QMEDLG
Sbjct: 96 AEVCFTQIRAGLHAYHDSLGAVLRLLPNHTTLVETLQLDAANLSSNIQQQMEDLGLDTVT 155
Query: 124 QPTQ--GAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
P + PTF+ FQ++ GG + + RFLE AYR LR+LA
Sbjct: 156 LPAEQRSPPPTFSGPFQQQVGGFFILANFQRFLETAYRALRHLA 199
>sp|:IL6_CAPHI (Q28319) Interleukin-6 precursor (IL-6)
Length = 208
Score = 177 bits (449), Expect = 3e-44
Identities = 30/165 (18%), Positives = 59/165 (35%), Gaps = 5/165 (3%)
Query: 3 PQSFLL----KCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXX 58
P LL K ++ I + +++ +C + C + L + L +P+
Sbjct: 42 PSRLLLTTPEKTEALIKHIVDKISAIRKEICEKNDECENSKETLAENKLKLPKMEEKDGC 101
Query: 59 XXXXXXR-GCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDL 117
+ CL + GL YQ L L T+ LQ + + ++ L
Sbjct: 102 FQSGFNQAICLIKTTAGLLEYQIYLDFLQNEFEGNQETVMELQSSIRTLIQILKEKIAGL 161
Query: 118 GAAPAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLR 162
PA ++ + + A +++ L FL+ + R +R
Sbjct: 162 ITTPATNTDMLEKMQSSNEWVKNAKVIIILRSLENFLQFSLRAIR 206
>tr|:Q90YI0 (Q90YI0) Interleukin-6 precursor
Length = 241
Score = 174 bits (443), Expect = 2e-43
Identities = 34/168 (20%), Positives = 62/168 (36%), Gaps = 9/168 (5%)
Query: 4 QSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQA-PXXXXXXXXX 62
+ LL C R ++ +LQ+ +C +C ML+R++L +P+
Sbjct: 68 RRALLDCEPLARVLRDRAVQLQDEMCKKFTVCENSMEMLVRNNLNLPKVTEEDGCLLAGF 127
Query: 63 XXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPA 122
CL +L GLF +Q L+ + +++L A I + +
Sbjct: 128 DEEKCLTKLSSGLFAFQTYLEFIQETFDSEKQNVESLCYSTKHLAATIRQMV--INPDEV 185
Query: 123 VQPTQGAMPTFTSAFQR------RAGGVLVASQLHRFLELAYRGLRYL 164
V P A + + + + L+ F+E R +RYL
Sbjct: 186 VIPDSAAQKSLLANLKSDKDWIEKITMHLILRDFTSFMEKTVRAVRYL 233
>tr|:Q9MZR1 (Q9MZR1) Interleukin 6
Length = 241
Score = 166 bits (421), Expect = 5e-41
Identities = 25/162 (15%), Positives = 56/162 (34%), Gaps = 11/162 (6%)
Query: 9 KCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXXXXRGC 67
+ +E +R I EL++ +C C + L +L +P+ C
Sbjct: 52 RTIESIRSILETIKELRKEMCDHDVNCMNRKEALAEVNLHLPRLIEEDGCFPPAVNNETC 111
Query: 68 LNQLHGGLFLYQGLLQALAGIS--PELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQP 125
L ++ GL ++ L+ L E + + ++ + ++++L ++P
Sbjct: 112 LLRITSGLMEFRMYLEHLQAKFRSDEENTRVSMVLKNIQHLIKTLRPKVKNLNEEATLKP 171
Query: 126 TQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGL 161
+ Q++ + L FLE R +
Sbjct: 172 AVAV--SLMENLQQKNQWLKTTTIHFILRGLTNFLEFTLRAV 211
>sp|:IL6_MARMO (O35736) Interleukin-6 precursor (IL-6)
Length = 207
Score = 159 bits (402), Expect = 8e-39
Identities = 27/163 (16%), Positives = 58/163 (35%), Gaps = 11/163 (6%)
Query: 9 KCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQA-PXXXXXXXXXXXRGC 67
K Q+ + + E+++ LC + C + + ++L +P+ C
Sbjct: 45 KTRRQISYLIKEVFEMRKELCKNDETCIKSHVAVSENNLNLPKMTEKDGCFQTGYNRDDC 104
Query: 68 LNQLHGGLFLYQGLLQALAGISPE--LAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQP 125
L ++ GL +Q L+ + E + +Q + +++D V P
Sbjct: 105 LVRITSGLLEFQVYLRYIRNKFQEGNNRDRAEHVQSSSKALIEILKQEVKD--PNKIVFP 162
Query: 126 TQGAMPTFTSA------FQRRAGGVLVASQLHRFLELAYRGLR 162
+ A + +Q+ L+ S FL+ R +R
Sbjct: 163 SPTANINLLAKLESQNDWQKVMTMQLILSNFEDFLQFTLRAVR 205
>tr|:Q9WVQ8 (Q9WVQ8) IL-6 (Fragment)
Length = 210
Score = 153 bits (388), Expect = 4e-37
Identities = 28/159 (17%), Positives = 54/159 (33%), Gaps = 10/159 (6%)
Query: 13 QVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP-XXXXXXXXXXXRGCLNQL 71
V + + EL++ LC + C + +LL ++L +P CL ++
Sbjct: 53 LVTYVLREIYELRKELCNNNPGCMDNDYVLLENNLELPVIQINDGCLQTGYNWEICLLKI 112
Query: 72 HGGLFLYQGLLQALAGI-SPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQGAM 130
GL YQ L+ + +Q + + +++ G V P+ +
Sbjct: 113 TSGLLDYQIYLEFVTNNVQDNKKDKARVIQSTIKTLSQIFKQEVK--GPDKIVTPSPTSK 170
Query: 131 PTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRY 163
+ + L+ L FLE+ R R
Sbjct: 171 AILMEKLESQKEWPRTKTIKLILKALEEFLEVTMRSTRQ 209
>sp|:IL6_MOUSE (P08505) Interleukin-6 precursor (IL-6) (Interleu
Length = 211
Score = 150 bits (381), Expect = 2e-36
Identities = 27/159 (16%), Positives = 52/159 (31%), Gaps = 10/159 (6%)
Query: 13 QVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP-XXXXXXXXXXXRGCLNQL 71
+ + + E+++ LC + C + L ++L +P+ CL ++
Sbjct: 54 LITHVLWEIVEMRKELCNGNSDCMNNDDALAENNLKLPEIQRNDGCYQTGYNQEICLLKI 113
Query: 72 HGGLFLYQGLLQALAGIS-PELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQGAM 130
GL Y L+ + LQ D +++DL V PT +
Sbjct: 114 SSGLLEYHSYLEYMKNNLKDNKKDKARVLQRDTETLIHIFNQEVKDLH--KIVLPTPISN 171
Query: 131 PTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRY 163
T + + + L FL++ R R
Sbjct: 172 ALLTDKLESQKEWLRTKTIQFILKSLEEFLKVTLRSTRQ 210
>sp|:IL6_RAT (P20607) Interleukin-6 precursor (IL-6)
Length = 211
Score = 138 bits (350), Expect = 1e-32
Identities = 23/159 (14%), Positives = 53/159 (32%), Gaps = 10/159 (6%)
Query: 13 QVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP-XXXXXXXXXXXRGCLNQL 71
+ + + E+++ LC + C + L ++L +P+ CL ++
Sbjct: 54 LITYVLREILEMRKELCNGNSDCMNSDDALSENNLKLPEIQRNDGCFQTGYNQEICLLKI 113
Query: 72 HGGLFLYQGLLQALAGI-SPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQGAM 130
GL ++ L+ + +Q + +++D + V PT +
Sbjct: 114 CSGLLEFRFYLEFVKNNLQDNKKDKARVIQSNTETLVHIFKQEIKD--SYKIVLPTPTSN 171
Query: 131 PTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRY 163
+ + L+ L FL++ R R
Sbjct: 172 ALLMEKLESQKEWLRTKTIQLILKALEEFLKVTMRSTRQ 210
>tr|:Q91ZL3 (Q91ZL3) Interleukin 6
Length = 212
Score = 135 bits (341), Expect = 1e-31
Identities = 23/161 (14%), Positives = 50/161 (30%), Gaps = 10/161 (6%)
Query: 11 LEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP-XXXXXXXXXXXRGCLN 69
+ ++ + ++ + LC + C + L ++L +P CL
Sbjct: 53 EGLITRVLKEILQMSKELCNNNPDCMTHDDALSENNLDLPVIERNDGCFQTGYDRENCLL 112
Query: 70 QLHGGLFLYQGLLQALAGI-SPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQG 128
++ GL YQ L+ L +Q + +++D P+
Sbjct: 113 KITSGLLDYQIYLEFLKNNVQDNKKERARVIQNSTKALNQILKQEVKD--PGKTATPSPT 170
Query: 129 AMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRY 163
+ + + L+ L FL++ R R
Sbjct: 171 SKVLLMEKLESQKDWPRTKTIQLILKALEEFLKITMRSTRQ 211
>tr|:O97535 (O97535) Interleukin-6 (Fragment)
Length = 160
Score = 135 bits (340), Expect = 1e-31
Identities = 22/111 (19%), Positives = 42/111 (37%), Gaps = 5/111 (4%)
Query: 3 PQSFLLKCLEQ----VRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXX 57
P LL EQ +R I A L++ +C +C + L ++L +P+ A
Sbjct: 42 PNRQLLTSTEQIDKHIRYILEGIAALRKEICDKSNMCESSKEALAENNLNLPKMAEKDGC 101
Query: 58 XXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFAT 108
CL ++ GL ++ L+ L +Q+ +++
Sbjct: 102 FQSGFNEETCLLKITTGLLEFEVYLEYLQNRFESSKEQAGAVQMSTKAWSS 152
>sp|:IL6_MUSVI (P41693) Interleukin-6 (IL-6) (Fragment)
Length = 125
Score = 134 bits (338), Expect = 2e-31
Identities = 17/129 (13%), Positives = 41/129 (31%), Gaps = 11/129 (8%)
Query: 43 LRHSLGIPQ-APXXXXXXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQL 101
++L +P+ A C+ ++ GL +Q L+ L ++ +
Sbjct: 1 AENNLKLPKLAEKDKCFQSQFNQETCMTRITTGLQEFQIHLKYLEANYEGNKNNAHSVYI 60
Query: 102 DVTDFATNIWLQMEDLGAAPAVQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLE 155
++ + P + + F+ + L+ L FL+
Sbjct: 61 STKHLL----QKLRPMNQVEVTTPNPTTDSSLQALFKSQDKWLKHVTIHLILRSLEDFLQ 116
Query: 156 LAYRGLRYL 164
+ R +R +
Sbjct: 117 FSLRAIRIM 125
>tn|:AAM34205 (AAM34205) Granulocyte colony-stimulating factor
Length = 127
Score = 129 bits (325), Expect = 7e-30
Identities = 98/125 (78%), Positives = 99/125 (78%)
Query: 41 MLLRHSLGIPQAPXXXXXXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQ 100
MLL HSLGIPQ GCL+QLH GL LYQGLLQALAGISPELAPTLD LQ
Sbjct: 1 MLLGHSLGIPQPLLSSCSSQALQLTGCLSQLHSGLLLYQGLLQALAGISPELAPTLDMLQ 60
Query: 101 LDVTDFATNIWLQMEDLGAAPAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRG 160
LDVTDFATNIW QMEDLG AP VQPT G MPTF SAFQRRAGGVLVAS L RFLELAYRG
Sbjct: 61 LDVTDFATNIWQQMEDLGVAPVVQPTHGPMPTFASAFQRRAGGVLVASNLQRFLELAYRG 120
Query: 161 LRYLA 165
LRYLA
Sbjct: 121 LRYLA 125
>tr|:Q9MZR0 (Q9MZR0) Interleukin 6 (Fragment)
Length = 118
Score = 113 bits (285), Expect = 3e-25
Identities = 15/108 (13%), Positives = 38/108 (34%), Gaps = 10/108 (9%)
Query: 65 RGCLNQLHGGLFLYQGLLQALAGIS--PELAPTLDTLQLDVTDFATNIWLQMEDLGAAPA 122
CL ++ GL +Q L+ L E + + ++ + ++++
Sbjct: 13 ETCLLRITSGLLEFQMYLEHLQAKFRSEEENTRVSMILKNMRHLINTLRPKVKNFNEGAT 72
Query: 123 VQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
++P + + Q++ + L FL+ R +R +
Sbjct: 73 LKP--AVVASLMENLQQKDQWLKTTTIHFILRGLTDFLQFTLRSVRLM 118
>tr|:Q9MZQ8 (Q9MZQ8) Interleukin 6 (Fragment)#tr|:Q9MZQ7 (Q9MZQ7)
Interleukin 6 (Fragment)
Length = 118
Score = 113 bits (283), Expect = 6e-25
Identities = 15/105 (14%), Positives = 38/105 (35%), Gaps = 10/105 (9%)
Query: 65 RGCLNQLHGGLFLYQGLLQALAGIS--PELAPTLDTLQLDVTDFATNIWLQMEDLGAAPA 122
CL ++ GL +Q L+ L E + + ++ + ++++L
Sbjct: 13 ETCLLRITSGLLEFQMYLEHLQAKFRSDEENTRVSMMLKNIRYLIKTLRPKVKNLNEGAT 72
Query: 123 VQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGL 161
++P + + Q++ + L FL+ + R +
Sbjct: 73 LKPAI--VASLMKNLQQKDQWLKTTTIHFILRNLTDFLQFSLRAV 115
>tr|:Q8SPS3 (Q8SPS3) Interleukin-6 (Fragment)
Length = 70
Score = 68.9 bits (168), Expect = 1e-11
Identities = 14/67 (20%), Positives = 18/67 (25%)
Query: 65 RGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQ 124
CL + GL YQ L L + LQ V + + DL P
Sbjct: 4 ETCLIRSTVGLLEYQAYLDYLQNEYEGDEENIKDLQSSVRTLLQIMRQKSIDLVTTPTAN 63
Query: 125 PTQGAMP 131
Sbjct: 64 LDLLEKM 70
Searching..................................................done
Results from round 5
Score E
Sequences producing significant alignments: (bits) Value
Sequences used in model and found again:
tr|:Q9XT80 (Q9XT80) Interleukin 6 218 1e-56
sp|:IL6_CANFA (P41323) Interleukin-6 precursor (IL-6) 215 1e-55
sp|:IL6_PIG (P26893) Interleukin-6 precursor (IL-6) 214 2e-55
tr|:Q28403 (Q28403) Interleukin 6 (Fragment) 210 2e-54
sp|:IL6_FELCA (P41683) Interleukin-6 precursor (IL-6) 204 2e-52
tr|:Q9GJU0 (Q9GJU0) Granulocyte colony-stimulating factor precu 203 3e-52
scop|:d1bgc__:a.26.1.1 (d1bgc__:a.26.1.1) 203 4e-52
sp|:CSF3_HUMAN (P09919) Granulocyte colony-stimulating factor p 202 5e-52
sp|:IL6_HORSE (Q95181) Interleukin-6 precursor (IL-6) 199 9e-51
sp|:IL6_PHOVI (Q28819) Interleukin-6 precursor (IL-6) (Fragment 198 1e-50
sp|:CSF3_PIG (O02837) Granulocyte colony-stimulating factor pre 194 2e-49
tr|:P97712 (P97712) Granulocyte colony stimulating factor 188 1e-47
tn|:AAK92044 (AAK92044) Interleukin-6 188 1e-47
tn|:AAM27192 (AAM27192) Interleukin-6 187 2e-47
sp|:IL6_BOVIN (P26892) Interleukin-6 precursor (IL-6) 187 2e-47
sp|:CSF3_MOUSE (P09920) Granulocyte colony-stimulating factor p 187 3e-47
sp|:IL6_CAPHI (Q28319) Interleukin-6 precursor (IL-6) 180 4e-45
scop|:d1alu__:a.26.1.1 (d1alu__:a.26.1.1) 179 8e-45
sp|:MGF_CHICK (P13854) Myelomonocytic growth factor precursor ( 172 6e-43
tr|:Q90YI0 (Q90YI0) Interleukin-6 precursor 171 1e-42
sp|:IL6_MARMO (O35736) Interleukin-6 precursor (IL-6) 169 6e-42
tr|:Q9MZR1 (Q9MZR1) Interleukin 6 167 3e-41
tr|:Q9WVQ8 (Q9WVQ8) IL-6 (Fragment) 167 3e-41
sp|:IL6_MOUSE (P08505) Interleukin-6 precursor (IL-6) (Interleu 165 7e-41
sp|:IL6_RAT (P20607) Interleukin-6 precursor (IL-6) 161 1e-39
tr|:Q91ZL3 (Q91ZL3) Interleukin 6 160 3e-39
sp|:IL6_MUSVI (P41693) Interleukin-6 (IL-6) (Fragment) 136 6e-32
tr|:O97535 (O97535) Interleukin-6 (Fragment) 133 5e-31
tn|:AAM34205 (AAM34205) Granulocyte colony-stimulating factor 127 4e-29
tr|:Q9MZR0 (Q9MZR0) Interleukin 6 (Fragment) 115 1e-25
tr|:Q9MZQ8 (Q9MZQ8) Interleukin 6 (Fragment)#tr|:Q9MZQ7 (Q9MZQ7)... 112 7e-25
tr|:Q8SPS3 (Q8SPS3) Interleukin-6 (Fragment) 78 3e-14
Sequences not found previously or not previously below threshold:
CONVERGED!
>tr|:Q9XT80 (Q9XT80) Interleukin 6
Length = 208
Score = 218 bits (556), Expect = 1e-56
Identities = 27/170 (15%), Positives = 61/170 (35%), Gaps = 10/170 (5%)
Query: 2 LPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXX 60
L + K ++ I + +++ +C + C + L ++L +P+ A
Sbjct: 40 LLLTSPDKTEALIKYILGKISAMRKEMCEKYDKCENSKEALAENNLNLPKMAEKDGCFQS 99
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
CL ++ GL YQ L L +++ +Q+ + A + +++
Sbjct: 100 GFNQETCLMRITTGLLEYQIYLDYLQNEYEGDKGSIEAVQISIKALAQILRQKVK--NPD 157
Query: 121 PAVQPTQGAMPTFTSAFQRR-------AGGVLVASQLHRFLELAYRGLRY 163
P + + Q + +L+ L FL+ + R +R
Sbjct: 158 EVTTPDPTTNASLMNNLQSQNDDWMRNTKIILILRSLENFLQFSLRAVRI 207
>sp|:IL6_CANFA (P41323) Interleukin-6 precursor (IL-6)
Length = 207
Score = 215 bits (548), Expect = 1e-55
Identities = 27/171 (15%), Positives = 58/171 (33%), Gaps = 9/171 (5%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP-XXXXXX 59
SLP + K E ++ I + L++ +C C + L ++L +P+
Sbjct: 39 SLPLTSANKVEELIKYILGKISALRKEMCDKFNKCEDSKEALAENNLHLPKLEGKDGCFQ 98
Query: 60 XXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGA 119
CL ++ GL +Q L L + ++ + + +++
Sbjct: 99 SGFNQETCLTRITTGLVEFQLHLNILQNNYEGDKENVKSVHMSTKILVQMLKSKVK--NQ 156
Query: 120 APAVQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
P + + Q + L+ L FL+ + R +R +
Sbjct: 157 DEVTTPDPTTDASLQAILQSQDECVKHTTIHLILRSLEDFLQFSLRAVRIM 207
>sp|:IL6_PIG (P26893) Interleukin-6 precursor (IL-6)
Length = 212
Score = 214 bits (545), Expect = 2e-55
Identities = 26/167 (15%), Positives = 59/167 (34%), Gaps = 9/167 (5%)
Query: 5 SFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXXX 63
+ K E ++ I + +++ +C ++ C + +L ++L +P+ A
Sbjct: 48 TSPDKTEELIKYILGKISAMRKEMCEKYEKCENSKEVLAENNLNLPKMAEKDGCFQSGFN 107
Query: 64 XRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAV 123
CL ++ GL +Q L L ++ +Q+ + + + A
Sbjct: 108 QETCLMRITTGLVEFQIYLDYLQKEYESNKGNVEAVQISTKALIQTLRQKGK--NPDKAT 165
Query: 124 QPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
P Q + +L+ L FL+ + R +R +
Sbjct: 166 TPNPTTNAGLLDKLQSQNEWMKNTKIILILRSLEDFLQFSLRAIRIM 212
>tr|:Q28403 (Q28403) Interleukin 6 (Fragment)
Length = 207
Score = 210 bits (536), Expect = 2e-54
Identities = 25/169 (14%), Positives = 58/169 (33%), Gaps = 11/169 (6%)
Query: 3 PQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXX 61
P + K + ++ I + L+ +C + C + +L ++L +P+ A
Sbjct: 43 PLTSADKMEDFIKFILGKISALRNEMCDKYNKCEDSKEVLAENNLNLPKLAEKDRCFQSR 102
Query: 62 XXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAP 121
CL ++ GL +Q L+ L ++ + + +
Sbjct: 103 FNQETCLTRITTGLQEFQIHLKYLESNYEGNKDNAHSVYISTKHLLQTLRP----MNQIE 158
Query: 122 AVQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
P + + F+ + L+ +L FL+ + R +R +
Sbjct: 159 VTTPDPTTDASLQALFKSQDKWLKHTTIHLILRRLEDFLQFSLRAIRIM 207
>sp|:IL6_FELCA (P41683) Interleukin-6 precursor (IL-6)
Length = 208
Score = 204 bits (520), Expect = 2e-52
Identities = 27/170 (15%), Positives = 56/170 (32%), Gaps = 9/170 (5%)
Query: 2 LPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXX 60
LP + K E ++ I + L++ +C + C + L ++L +P+ A
Sbjct: 41 LPLTSADKMEELIKYILGKISALKKEMCDNYNKCEDSKEALAENNLNLPKLAEKDGCFQS 100
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
CL ++ GL +Q L+ L ++ + + +
Sbjct: 101 GFNQETCLTRITTGLQEFQIYLKFLQDKYEGDEENAKSVYTSTNVLLQMLKRKGK--NQD 158
Query: 121 PAVQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
P + Q + L +L FL+ + R +R +
Sbjct: 159 EVTIPVPTVEVGLQAKLQSQEEWLRHTTIHLTLRRLEDFLQFSLRAVRIM 208
>tr|:Q9GJU0 (Q9GJU0) Granulocyte colony-stimulating factor precu
Length = 195
Score = 203 bits (518), Expect = 3e-52
Identities = 128/163 (78%), Positives = 135/163 (82%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXX 60
SLPQSFLLKCLEQVRK+QADG LQERLCAAHKLCHPEEL+LL H+LGIPQAP
Sbjct: 29 SLPQSFLLKCLEQVRKVQADGTALQERLCAAHKLCHPEELVLLGHALGIPQAPLSSCSSQ 88
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
GCL QLH GLFLYQGLLQALAGISPELAPTLD LQLD+TDFA NIW QMED+G A
Sbjct: 89 ALQLTGCLRQLHSGLFLYQGLLQALAGISPELAPTLDMLQLDITDFAINIWQQMEDVGMA 148
Query: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRY 163
PAV PTQG MPTFTSAFQRRAGG LVAS L FLE+AYR LR+
Sbjct: 149 PAVPPTQGTMPTFTSAFQRRAGGTLVASNLQSFLEVAYRALRH 191
>scop|:d1bgc__:a.26.1.1 (d1bgc__:a.26.1.1)
Length = 165
Score = 203 bits (517), Expect = 4e-52
Identities = 154/165 (93%), Positives = 154/165 (93%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXX 60
SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP
Sbjct: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPLSSCSSQ 60
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
RGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA
Sbjct: 61 SLQLRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
Query: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA
Sbjct: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
>sp|:CSF3_HUMAN (P09919) Granulocyte colony-stimulating factor p
Length = 207
Score = 202 bits (516), Expect = 5e-52
Identities = 126/168 (75%), Positives = 135/168 (80%), Gaps = 3/168 (1%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERL---CAAHKLCHPEELMLLRHSLGIPQAPXXXX 57
SLPQSFLLKCLEQVRKIQ DGA LQE+L CA +KLCHPEEL+LL HSLGIP AP
Sbjct: 38 SLPQSFLLKCLEQVRKIQGDGAALQEKLVSECATYKLCHPEELVLLGHSLGIPWAPLSSC 97
Query: 58 XXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDL 117
GCL+QLH GLFLYQGLLQAL GISPEL PTLDTLQLDV DFAT IW QME+L
Sbjct: 98 PSQALQLAGCLSQLHSGLFLYQGLLQALEGISPELGPTLDTLQLDVADFATTIWQQMEEL 157
Query: 118 GAAPAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
G APA+QPTQGAMP F SAFQRRAGGVLVAS L FLE++YR LR+LA
Sbjct: 158 GMAPALQPTQGAMPAFASAFQRRAGGVLVASHLQSFLEVSYRVLRHLA 205
>sp|:IL6_HORSE (Q95181) Interleukin-6 precursor (IL-6)
Length = 208
Score = 199 bits (506), Expect = 9e-51
Identities = 27/168 (16%), Positives = 59/168 (35%), Gaps = 10/168 (5%)
Query: 4 QSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXX 62
+ K + ++ I + L+ +C C + +L ++L +P+ A
Sbjct: 44 LTTADKTKQHIKYILGKISALKNEMCNNFSKCENSKEVLAENNLNLPKMAEKDGCFQSGF 103
Query: 63 XXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPA 122
CL ++ GL +Q L+ L + T+Q+ + +M++
Sbjct: 104 NQETCLMKITTGLSEFQIYLEYLQNEFKGEKENIKTMQISTKVLVQILMQKMKN---PEV 160
Query: 123 VQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
P A + + + L+ L FL+ + R +R +
Sbjct: 161 TTPDPTAKSSLLAKLHSQNEWLKNTTTHLILRSLEDFLQFSLRAVRIM 208
>sp|:IL6_PHOVI (Q28819) Interleukin-6 precursor (IL-6) (Fragment
Length = 209
Score = 198 bits (504), Expect = 1e-50
Identities = 24/169 (14%), Positives = 59/169 (34%), Gaps = 9/169 (5%)
Query: 3 PQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXX 61
P + K E ++ I + L++ +C + C + L ++L +P+ A
Sbjct: 43 PLTSPDKMEEFIKYILGKISALRKEMCDKYNKCEDSKEALAENNLRLPKLAEKDGCFQSG 102
Query: 62 XXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAP 121
CL ++ GL +Q L+ + +++ + + +++
Sbjct: 103 FNQETCLTRITTGLLEFQIHLKYIQANYEGNKEDANSVYISTKLLVQMLMKKVKS--QDE 160
Query: 122 AVQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
P + + + + L+ L FL+ + R +R +
Sbjct: 161 VTTPDPTTDTSLQAILKAQDKWLKHTTIHLILRSLEDFLQFSLRAVRIM 209
>sp|:CSF3_PIG (O02837) Granulocyte colony-stimulating factor pre
Length = 195
Score = 194 bits (494), Expect = 2e-49
Identities = 133/165 (80%), Positives = 137/165 (82%)
Query: 1 SLPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXX 60
SLPQSFLLKCLEQVRKIQADGAELQERLCA HKLCHP+EL+LL HSLG+PQA
Sbjct: 29 SLPQSFLLKCLEQVRKIQADGAELQERLCATHKLCHPQELVLLGHSLGLPQASLSSCSSQ 88
Query: 61 XXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
GCLNQLHGGL LYQGLLQALAGISPELAP LD LQLDVTD ATNIWLQMEDL A
Sbjct: 89 ALQLTGCLNQLHGGLVLYQGLLQALAGISPELAPALDILQLDVTDLATNIWLQMEDLRMA 148
Query: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
PA PTQG +PTFTSAFQRRAGGVLV SQL FLELAYR LRYLA
Sbjct: 149 PASLPTQGTVPTFTSAFQRRAGGVLVVSQLQSFLELAYRVLRYLA 193
>tr|:P97712 (P97712) Granulocyte colony stimulating factor
Length = 214
Score = 188 bits (479), Expect = 1e-47
Identities = 111/163 (68%), Positives = 120/163 (73%)
Query: 2 LPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXX 61
LP+SFLLK LEQVRKIQA EL E+LCA +KLCHPEEL+L HSLGIP+A
Sbjct: 36 LPRSFLLKSLEQVRKIQARNTELLEQLCATYKLCHPEELVLFGHSLGIPKASLSSCSSQA 95
Query: 62 XXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAP 121
CL+QLH GLFLYQGLLQALAGIS ELAPTLD L LDV +FAT IW QME LG AP
Sbjct: 96 LQQTKCLSQLHSGLFLYQGLLQALAGISSELAPTLDMLHLDVDNFATTIWQQMESLGVAP 155
Query: 122 AVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYL 164
VQPTQ MP FTSAFQRRAGGVLV S L FLE A+ L +L
Sbjct: 156 TVQPTQSTMPIFTSAFQRRAGGVLVTSYLQSFLETAHHALHHL 198
>tn|:AAK92044 (AAK92044) Interleukin-6
Length = 212
Score = 188 bits (478), Expect = 1e-47
Identities = 28/173 (16%), Positives = 59/173 (33%), Gaps = 13/173 (7%)
Query: 3 PQSFLLKCLEQVR----KIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXX 57
P LL E++ I + L++ +C +C + L ++L +P+ A
Sbjct: 42 PNRQLLTSTERIDKHIWYILDGISALRKEICNKSNMCESSKEALAENNLNLPKMAEKDGC 101
Query: 58 XXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDL 117
CL ++ GL ++ L+ L +Q+ ++ + ++L
Sbjct: 102 FQSGFNEETCLLKITTGLLEFEVYLEYLQNRFESSKEQAGAVQMSTKGLIQSLQRKAKNL 161
Query: 118 GAAPAVQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
P + + Q + L+ FL+ + R LR +
Sbjct: 162 S--AIATPDPATNASLLTKLQAQDQWLQGVTTHLILRSFKEFLQCSLRALRQM 212
>tn|:AAM27192 (AAM27192) Interleukin-6
Length = 214
Score = 187 bits (476), Expect = 2e-47
Identities = 20/137 (14%), Positives = 47/137 (33%), Gaps = 3/137 (2%)
Query: 5 SFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXXX 63
+ K E ++ I + +++ +C ++ C + +L ++L +P+ A
Sbjct: 48 TSPDKTEELIKYILGKISAMRKEMCEKYEKCENSKEVLAENNLNLPKMAEKDGCFQSGFN 107
Query: 64 XRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAV 123
CL ++ GL +Q L L ++ +Q+ + + + A
Sbjct: 108 QETCLMRITTGLVEFQIYLDYLQKEYESNKGNVEAVQISTKALIQTLRQKGK--NPDKAT 165
Query: 124 QPTQGAMPTFTSAFQRR 140
P Q +
Sbjct: 166 TPNPTTNAGLLDKLQSQ 182
>sp|:IL6_BOVIN (P26892) Interleukin-6 precursor (IL-6)
Length = 208
Score = 187 bits (476), Expect = 2e-47
Identities = 27/162 (16%), Positives = 60/162 (36%), Gaps = 1/162 (0%)
Query: 2 LPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXX 61
L + K ++++ + +++ +C + C + L + L +P+
Sbjct: 45 LLLTTPEKTEALIKRMVDKISAMRKEICEKNDECESSKETLAENKLNLPKMEEKDGCFQS 104
Query: 62 XXXR-GCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
+ CL + GL YQ L L + L+ ++ + ++ DL
Sbjct: 105 GFNQAICLIRTTAGLLEYQIYLDYLQNEYEGNQENVRDLRKNIRTLIQILKQKIADLITT 164
Query: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLR 162
PA ++ + + A +L+ L FL+ + R +R
Sbjct: 165 PATNTDLLEKMQSSNEWVKNAKIILILRNLENFLQFSLRAIR 206
>sp|:CSF3_MOUSE (P09920) Granulocyte colony-stimulating factor p
Length = 208
Score = 187 bits (475), Expect = 3e-47
Identities = 112/164 (68%), Positives = 123/164 (74%)
Query: 2 LPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXX 61
LP+SFLLK LEQVRKIQA G+ L E+LCA +KLCHPEEL+LL HSLGIP+A
Sbjct: 45 LPRSFLLKSLEQVRKIQASGSVLLEQLCATYKLCHPEELVLLGHSLGIPKASLSGCSSQA 104
Query: 62 XXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAP 121
CL+QLH GL LYQGLLQAL+GISP LAPTLD LQLDV +FAT IW QME+LG AP
Sbjct: 105 LQQTQCLSQLHSGLCLYQGLLQALSGISPALAPTLDLLQLDVANFATTIWQQMENLGVAP 164
Query: 122 AVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
VQPTQ AMP FTSAFQRRAGGVL S L FLE A L +LA
Sbjct: 165 TVQPTQSAMPAFTSAFQRRAGGVLAISYLQGFLETARLALHHLA 208
>sp|:IL6_CAPHI (Q28319) Interleukin-6 precursor (IL-6)
Length = 208
Score = 180 bits (457), Expect = 4e-45
Identities = 28/162 (17%), Positives = 58/162 (35%), Gaps = 1/162 (0%)
Query: 2 LPQSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXX 61
L + K ++ I + +++ +C + C + L + L +P+
Sbjct: 45 LLLTTPEKTEALIKHIVDKISAIRKEICEKNDECENSKETLAENKLKLPKMEEKDGCFQS 104
Query: 62 XXXR-GCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAA 120
+ CL + GL YQ L L T+ LQ + + ++ L
Sbjct: 105 GFNQAICLIKTTAGLLEYQIYLDFLQNEFEGNQETVMELQSSIRTLIQILKEKIAGLITT 164
Query: 121 PAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLR 162
PA ++ + + A +++ L FL+ + R +R
Sbjct: 165 PATNTDMLEKMQSSNEWVKNAKVIIILRSLENFLQFSLRAIR 206
>scop|:d1alu__:a.26.1.1 (d1alu__:a.26.1.1)
Length = 166
Score = 179 bits (454), Expect = 8e-45
Identities = 26/159 (16%), Positives = 54/159 (33%), Gaps = 9/159 (5%)
Query: 13 QVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXXXXRGCLNQL 71
Q+R I + L++ C +C + L ++L +P+ A CL ++
Sbjct: 10 QIRYILDGISALRKETCNKSNMCESSKEALAENNLNLPKMAEKDGCFQSGFNEETCLVKI 69
Query: 72 HGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQGAMP 131
GL ++ L+ L +Q+ + + ++L P
Sbjct: 70 ITGLLEFEVYLEYLQNRFESSEEQARAVQMSTKVLIQFLQKKAKNL--DAITTPDPTTNA 127
Query: 132 TFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
+ + Q + L+ FL+ + R LR +
Sbjct: 128 SLLTKLQAQNQWLQDMTTHLILRSFKEFLQSSLRALRQM 166
>sp|:MGF_CHICK (P13854) Myelomonocytic growth factor precursor (
Length = 201
Score = 172 bits (438), Expect = 6e-43
Identities = 63/164 (38%), Positives = 84/164 (50%), Gaps = 2/164 (1%)
Query: 4 QSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAPXXXXXXXXXX 63
Q FL K LE RKI+ D A LQ +C +LC EEL L++ + QAP
Sbjct: 36 QLFLHKNLEFTRKIRGDVAALQRAVCDTFQLCTEEELQLVQPDPHLVQAPLDQCHKRGFQ 95
Query: 64 XRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAV 123
C Q+ GL Y L A+ + P ++TLQLD + ++NI QMEDLG
Sbjct: 96 AEVCFTQIRAGLHAYHDSLGAVLRLLPNHTTLVETLQLDAANLSSNIQQQMEDLGLDTVT 155
Query: 124 QPTQ--GAMPTFTSAFQRRAGGVLVASQLHRFLELAYRGLRYLA 165
P + PTF+ FQ++ GG + + RFLE AYR LR+LA
Sbjct: 156 LPAEQRSPPPTFSGPFQQQVGGFFILANFQRFLETAYRALRHLA 199
>tr|:Q90YI0 (Q90YI0) Interleukin-6 precursor
Length = 241
Score = 171 bits (435), Expect = 1e-42
Identities = 34/168 (20%), Positives = 62/168 (36%), Gaps = 9/168 (5%)
Query: 4 QSFLLKCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQA-PXXXXXXXXX 62
+ LL C R ++ +LQ+ +C +C ML+R++L +P+
Sbjct: 68 RRALLDCEPLARVLRDRAVQLQDEMCKKFTVCENSMEMLVRNNLNLPKVTEEDGCLLAGF 127
Query: 63 XXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPA 122
CL +L GLF +Q L+ + +++L A I + +
Sbjct: 128 DEEKCLTKLSSGLFAFQTYLEFIQETFDSEKQNVESLCYSTKHLAATIRQMV--INPDEV 185
Query: 123 VQPTQGAMPTFTSAFQR------RAGGVLVASQLHRFLELAYRGLRYL 164
V P A + + + + L+ F+E R +RYL
Sbjct: 186 VIPDSAAQKSLLANLKSDKDWIEKITMHLILRDFTSFMEKTVRAVRYL 233
>sp|:IL6_MARMO (O35736) Interleukin-6 precursor (IL-6)
Length = 207
Score = 169 bits (429), Expect = 6e-42
Identities = 25/163 (15%), Positives = 56/163 (34%), Gaps = 11/163 (6%)
Query: 9 KCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQA-PXXXXXXXXXXXRGC 67
K Q+ + + E+++ LC + C + + ++L +P+ C
Sbjct: 45 KTRRQISYLIKEVFEMRKELCKNDETCIKSHVAVSENNLNLPKMTEKDGCFQTGYNRDDC 104
Query: 68 LNQLHGGLFLYQGLLQALAGISP--ELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQP 125
L ++ GL +Q L+ + + +Q + +++D V P
Sbjct: 105 LVRITSGLLEFQVYLRYIRNKFQEGNNRDRAEHVQSSSKALIEILKQEVKD--PNKIVFP 162
Query: 126 TQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLR 162
+ A + + + L+ S FL+ R +R
Sbjct: 163 SPTANINLLAKLESQNDWQKVMTMQLILSNFEDFLQFTLRAVR 205
>tr|:Q9MZR1 (Q9MZR1) Interleukin 6
Length = 241
Score = 167 bits (424), Expect = 3e-41
Identities = 25/165 (15%), Positives = 57/165 (34%), Gaps = 11/165 (6%)
Query: 9 KCLEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXXXXXXXXXRGC 67
+ +E +R I EL++ +C C + L +L +P+ C
Sbjct: 52 RTIESIRSILETIKELRKEMCDHDVNCMNRKEALAEVNLHLPRLIEEDGCFPPAVNNETC 111
Query: 68 LNQLHGGLFLYQGLLQALAGIS--PELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQP 125
L ++ GL ++ L+ L E + + ++ + ++++L ++P
Sbjct: 112 LLRITSGLMEFRMYLEHLQAKFRSDEENTRVSMVLKNIQHLIKTLRPKVKNLNEEATLKP 171
Query: 126 TQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
+ Q++ + L FLE R + +
Sbjct: 172 AVAV--SLMENLQQKNQWLKTTTIHFILRGLTNFLEFTLRAVDLM 214
>tr|:Q9WVQ8 (Q9WVQ8) IL-6 (Fragment)
Length = 210
Score = 167 bits (424), Expect = 3e-41
Identities = 28/159 (17%), Positives = 54/159 (33%), Gaps = 10/159 (6%)
Query: 13 QVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP-XXXXXXXXXXXRGCLNQL 71
V + + EL++ LC + C + +LL ++L +P CL ++
Sbjct: 53 LVTYVLREIYELRKELCNNNPGCMDNDYVLLENNLELPVIQINDGCLQTGYNWEICLLKI 112
Query: 72 HGGLFLYQGLLQALAGI-SPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQGAM 130
GL YQ L+ + +Q + + +++ G V P+ +
Sbjct: 113 TSGLLDYQIYLEFVTNNVQDNKKDKARVIQSTIKTLSQIFKQEVK--GPDKIVTPSPTSK 170
Query: 131 PTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRY 163
+ + L+ L FLE+ R R
Sbjct: 171 AILMEKLESQKEWPRTKTIKLILKALEEFLEVTMRSTRQ 209
>sp|:IL6_MOUSE (P08505) Interleukin-6 precursor (IL-6) (Interleu
Length = 211
Score = 165 bits (420), Expect = 7e-41
Identities = 27/159 (16%), Positives = 52/159 (31%), Gaps = 10/159 (6%)
Query: 13 QVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP-XXXXXXXXXXXRGCLNQL 71
+ + + E+++ LC + C + L ++L +P+ CL ++
Sbjct: 54 LITHVLWEIVEMRKELCNGNSDCMNNDDALAENNLKLPEIQRNDGCYQTGYNQEICLLKI 113
Query: 72 HGGLFLYQGLLQALAGIS-PELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQGAM 130
GL Y L+ + LQ D +++DL V PT +
Sbjct: 114 SSGLLEYHSYLEYMKNNLKDNKKDKARVLQRDTETLIHIFNQEVKDLH--KIVLPTPISN 171
Query: 131 PTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRY 163
T + + + L FL++ R R
Sbjct: 172 ALLTDKLESQKEWLRTKTIQFILKSLEEFLKVTLRSTRQ 210
>sp|:IL6_RAT (P20607) Interleukin-6 precursor (IL-6)
Length = 211
Score = 161 bits (409), Expect = 1e-39
Identities = 23/159 (14%), Positives = 53/159 (32%), Gaps = 10/159 (6%)
Query: 13 QVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP-XXXXXXXXXXXRGCLNQL 71
+ + + E+++ LC + C + L ++L +P+ CL ++
Sbjct: 54 LITYVLREILEMRKELCNGNSDCMNSDDALSENNLKLPEIQRNDGCFQTGYNQEICLLKI 113
Query: 72 HGGLFLYQGLLQALAGI-SPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQGAM 130
GL ++ L+ + +Q + +++D + V PT +
Sbjct: 114 CSGLLEFRFYLEFVKNNLQDNKKDKARVIQSNTETLVHIFKQEIKD--SYKIVLPTPTSN 171
Query: 131 PTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRY 163
+ + L+ L FL++ R R
Sbjct: 172 ALLMEKLESQKEWLRTKTIQLILKALEEFLKVTMRSTRQ 210
>tr|:Q91ZL3 (Q91ZL3) Interleukin 6
Length = 212
Score = 160 bits (406), Expect = 3e-39
Identities = 23/161 (14%), Positives = 50/161 (30%), Gaps = 10/161 (6%)
Query: 11 LEQVRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQAP-XXXXXXXXXXXRGCLN 69
+ ++ + ++ + LC + C + L ++L +P CL
Sbjct: 53 EGLITRVLKEILQMSKELCNNNPDCMTHDDALSENNLDLPVIERNDGCFQTGYDRENCLL 112
Query: 70 QLHGGLFLYQGLLQALAGI-SPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQPTQG 128
++ GL YQ L+ L +Q + +++D P+
Sbjct: 113 KITSGLLDYQIYLEFLKNNVQDNKKERARVIQNSTKALNQILKQEVKD--PGKTATPSPT 170
Query: 129 AMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRY 163
+ + + L+ L FL++ R R
Sbjct: 171 SKVLLMEKLESQKDWPRTKTIQLILKALEEFLKITMRSTRQ 211
>sp|:IL6_MUSVI (P41693) Interleukin-6 (IL-6) (Fragment)
Length = 125
Score = 136 bits (343), Expect = 6e-32
Identities = 17/129 (13%), Positives = 41/129 (31%), Gaps = 11/129 (8%)
Query: 43 LRHSLGIPQ-APXXXXXXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQL 101
++L +P+ A C+ ++ GL +Q L+ L ++ +
Sbjct: 1 AENNLKLPKLAEKDKCFQSQFNQETCMTRITTGLQEFQIHLKYLEANYEGNKNNAHSVYI 60
Query: 102 DVTDFATNIWLQMEDLGAAPAVQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLE 155
++ + P + + F+ + L+ L FL+
Sbjct: 61 STKHLL----QKLRPMNQVEVTTPNPTTDSSLQALFKSQDKWLKHVTIHLILRSLEDFLQ 116
Query: 156 LAYRGLRYL 164
+ R +R +
Sbjct: 117 FSLRAIRIM 125
>tr|:O97535 (O97535) Interleukin-6 (Fragment)
Length = 160
Score = 133 bits (336), Expect = 5e-31
Identities = 22/111 (19%), Positives = 42/111 (37%), Gaps = 5/111 (4%)
Query: 3 PQSFLLKCLEQ----VRKIQADGAELQERLCAAHKLCHPEELMLLRHSLGIPQ-APXXXX 57
P LL EQ +R I A L++ +C +C + L ++L +P+ A
Sbjct: 42 PNRQLLTSTEQIDKHIRYILEGIAALRKEICDKSNMCESSKEALAENNLNLPKMAEKDGC 101
Query: 58 XXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFAT 108
CL ++ GL ++ L+ L +Q+ +++
Sbjct: 102 FQSGFNEETCLLKITTGLLEFEVYLEYLQNRFESSKEQAGAVQMSTKAWSS 152
>tn|:AAM34205 (AAM34205) Granulocyte colony-stimulating factor
Length = 127
Score = 127 bits (319), Expect = 4e-29
Identities = 98/125 (78%), Positives = 99/125 (78%)
Query: 41 MLLRHSLGIPQAPXXXXXXXXXXXRGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQ 100
MLL HSLGIPQ GCL+QLH GL LYQGLLQALAGISPELAPTLD LQ
Sbjct: 1 MLLGHSLGIPQPLLSSCSSQALQLTGCLSQLHSGLLLYQGLLQALAGISPELAPTLDMLQ 60
Query: 101 LDVTDFATNIWLQMEDLGAAPAVQPTQGAMPTFTSAFQRRAGGVLVASQLHRFLELAYRG 160
LDVTDFATNIW QMEDLG AP VQPT G MPTF SAFQRRAGGVLVAS L RFLELAYRG
Sbjct: 61 LDVTDFATNIWQQMEDLGVAPVVQPTHGPMPTFASAFQRRAGGVLVASNLQRFLELAYRG 120
Query: 161 LRYLA 165
LRYLA
Sbjct: 121 LRYLA 125
>tr|:Q9MZR0 (Q9MZR0) Interleukin 6 (Fragment)
Length = 118
Score = 115 bits (289), Expect = 1e-25
Identities = 15/108 (13%), Positives = 38/108 (34%), Gaps = 10/108 (9%)
Query: 65 RGCLNQLHGGLFLYQGLLQALAGIS--PELAPTLDTLQLDVTDFATNIWLQMEDLGAAPA 122
CL ++ GL +Q L+ L E + + ++ + ++++
Sbjct: 13 ETCLLRITSGLLEFQMYLEHLQAKFRSEEENTRVSMILKNMRHLINTLRPKVKNFNEGAT 72
Query: 123 VQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
++P + + Q++ + L FL+ R +R +
Sbjct: 73 LKP--AVVASLMENLQQKDQWLKTTTIHFILRGLTDFLQFTLRSVRLM 118
>tr|:Q9MZQ8 (Q9MZQ8) Interleukin 6 (Fragment)#tr|:Q9MZQ7 (Q9MZQ7)
Interleukin 6 (Fragment)
Length = 118
Score = 112 bits (282), Expect = 7e-25
Identities = 15/108 (13%), Positives = 39/108 (35%), Gaps = 10/108 (9%)
Query: 65 RGCLNQLHGGLFLYQGLLQALAGIS--PELAPTLDTLQLDVTDFATNIWLQMEDLGAAPA 122
CL ++ GL +Q L+ L E + + ++ + ++++L
Sbjct: 13 ETCLLRITSGLLEFQMYLEHLQAKFRSDEENTRVSMMLKNIRYLIKTLRPKVKNLNEGAT 72
Query: 123 VQPTQGAMPTFTSAFQRR------AGGVLVASQLHRFLELAYRGLRYL 164
++P + + Q++ + L FL+ + R + +
Sbjct: 73 LKPAI--VASLMKNLQQKDQWLKTTTIHFILRNLTDFLQFSLRAVGLM 118
>tr|:Q8SPS3 (Q8SPS3) Interleukin-6 (Fragment)
Length = 70
Score = 77.7 bits (191), Expect = 3e-14
Identities = 14/67 (20%), Positives = 18/67 (25%)
Query: 65 RGCLNQLHGGLFLYQGLLQALAGISPELAPTLDTLQLDVTDFATNIWLQMEDLGAAPAVQ 124
CL + GL YQ L L + LQ V + + DL P
Sbjct: 4 ETCLIRSTVGLLEYQAYLDYLQNEYEGDEENIKDLQSSVRTLLQIMRQKSIDLVTTPTAN 63
Query: 125 PTQGAMP 131
Sbjct: 64 LDLLEKM 70
Database: /data/tmp/fabascal/DBASE/scop+nr100.faa.nrdb90.reformated
Posted date: Jul 30, 2002 10:40 AM
Number of letters in database: 166,026,790
Number of sequences in database: 475,909
Lambda K H
0.312 0.181 0.523
Lambda K H
0.267 0.0555 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 343,087,452
Number of Sequences: 475909
Number of extensions: 17061274
Number of successful extensions: 53486
Number of sequences better than 5.0e-03: 112
Number of HSP's better than 0.0 without gapping: 97
Number of HSP's successfully gapped in prelim test: 17
Number of HSP's that attempted gapping in prelim test: 53199
Number of HSP's gapped (non-prelim): 115
length of query: 165
length of database: 166,026,790
effective HSP length: 108
effective length of query: 57
effective length of database: 114,628,618
effective search space: 6533831226
effective search space used: 6533831226
T: 11
A: 40
X1: 15 ( 6.8 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (20.5 bits)
S2: 94 (40.4 bits)