SEQUENCE ALIGNMENTS AND PROTEIN FAMILIES

Presentations

• Sequence alignment and Protein Families

Practical lessons

1. Pairwise and Multiple Sequence alignments. Similarity Searches
2. Command line BLAST and Sequence Clustering with PERL

A selection of links

• NCBI BLAST
• WU-BLAST at EMBL
• WU-BLAST at EBI
• ClustalW at EBI
• T-Coffee server
• T-Coffee home page

• COGs . Clusters of Orthologous Groups of proteins, at NCBI.
• InParanoid . Database of pairwise orthologs, at CGB, Karolinska Institute, Sweden.
• ProtoMap . Hierarchical classification of all proteins in SWISSPROT and TrEMBL.