The Data
- PDBsum, exons, functional residues, model structures and preliminary analysis using ProFunc
Here, the sequences are grouped together by their ENCODE reference
id so that the splice variants are side by side. Also added is a
column showing numbers of exons making up each sequence.
A preliminary set of 3D models have been generated for 6 of the
structures using SWISS-MODEL.
Each of these now has a PDBsum page, including a wiring diagram
showing the exon splice positions and a corresponding RasMol
showing how the exons form the 3D structure.
The sequences with 3D structures are identified by a red ball in
the list above (eg the first red ball is for abf9). Click on the
ball to go to the PDBsum page. Then go to the "Protein" analysis
to get the usual wiring diagram. Underneath, you will see a pair
of scissors. Click on these to go to the wiring diagram showing
the exon splice sites. The RasMol button will show the
individually coloured exon segments on the model of the 3D structure.
This work was carried out by Roman Laskowski and Gabrielle Reeves from the Thornton Group and Russell Marsden from the CATH group at UCL.
