[1]
SEQUENCE FROM N.A.
MEDLINE=89302693 [NCBI, ExPASy, Israel, Japan]; PubMed=2472816;
Streicher R., Stoffel W.;
"The organization of the human myelin basic protein gene. Comparison with the mouse gene.";
Biol. Chem. Hoppe-Seyler 370:503-510(1989).

[2]
SEQUENCE FROM N.A.
MEDLINE=87311781 [NCBI, ExPASy, Israel, Japan]; PubMed=2442403;
Roth H.J., Kronquist K.E., de Rosbo N., Crandall B.F., Campagnoni A.T.;
"Evidence for the expression of four myelin basic protein variants in the developing human spinal cord through cDNA cloning.";
J. Neurosci. Res. 17:321-328(1987).

[3]
SEQUENCE OF 1-58; 85-131 AND 143-196 FROM N.A.
MEDLINE=86308101 [NCBI, ExPASy, Israel, Japan]; PubMed=2427738;
Roth H.J., Kronquist K.E., Pretorius P.J., Crandall B.F., Campagnoni A.T.;
"Isolation and characterization of a cDNA coding for a novel human 17.3K myelin basic protein (MBP) variant.";
J. Neurosci. Res. 16:227-238(1986).

[4]
SEQUENCE OF 1-58 AND 85-196 FROM N.A.
MEDLINE=86259714 [NCBI, ExPASy, Israel, Japan]; PubMed=2425357;
Kamholz J., de Ferra F., Puckett C., Lazzarini R.A.;
"Identification of three forms of human myelin basic protein by cDNA cloning.";
Proc. Natl. Acad. Sci. U.S.A. 83:4962-4966(1986).

[5]
SEQUENCE OF 1-58 AND 85-196.
MEDLINE=72066400 [NCBI, ExPASy, Israel, Japan]; PubMed=4108501;
Carnegie P.R.;
"Amino acid sequence of the encephalitogenic basic protein from human myelin.";
Biochem. J. 123:57-67(1971).

[6]
SEQUENCE OF 45-58 AND 85-114, AND REVISIONS.
Shapira R., McKneally S.S., Chou F., Kibler R.F.;
"Encephalitogenic fragment of myelin basic protein. Amino acid sequence of bovine, rabbit, guinea pig, monkey, and human fragments.";
J. Biol. Chem. 246:4630-4640(1971).

[7]
SEQUENCE OF 1-58 FROM N.A.
MEDLINE=90152679 [NCBI, ExPASy, Israel, Japan]; PubMed=1689270;
Boylan K.B., Ayres T.M., Popko B., Takahashi N., Hood L.E., Prusiner S.B.;
"Repetitive DNA (TGGA)n 5' to the human myelin basic protein gene: a new form of oligonucleotide repetitive sequence showing length polymorphism.";
Genomics 6:16-22(1990).

[8]
METHYLATION.
MEDLINE=72066401 [NCBI, ExPASy, Israel, Japan]; PubMed=5128665;
Baldwin G.S., Carnegie P.R.;
"Isolation and partial characterization of methylated arginines from the encephalitogenic basic protein of myelin.";
Biochem. J. 123:69-74(1971).

[9]
3D-STRUCTURE MODELING OF 1-171.
MEDLINE=97172499 [NCBI, ExPASy, Israel, Japan]; PubMed=9020143;
Ridsdale R.A., Beniac D.R., Tompkins T.A., Moscarello M.A., Harauz G.;
"Three-dimensional structure of myelin basic protein. II. Molecular modeling and considerations of predicted structures in multiple sclerosis.";
J. Biol. Chem. 272:4269-4275(1997).

Comments

FUNCTION: THIS PROTEIN MAY FUNCTION TO MAINTAIN PROPER STRUCTURE OF MYELIN.
SUBCELLULAR LOCATION: CYTOPLASMIC SIDE OF MYELIN.
ALTERNATIVE PRODUCTS: 3 ISOFORMS; 21.5 KDA (SHOWN HERE), 18.5 KDA (THE MOST ABUNDANT) AND 17.2 KDA; ARE PRODUCED BY ALTERNATIVE SPLICING.
SIMILARITY: BELONGS TO THE MYELIN BASIC PROTEIN FAMILY.

Copyright

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Cross-references

EMBL	M13577; AAA59562.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] M30516; AAA59563.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] M30515; AAA59564.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] M30047; AAA59559.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] X17286; CAA35179.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence] X17287; CAA35179.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] X17290; CAA35179.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] X17288; CAA35179.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] X17369; CAA35179.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] X17289; CAA35179.1; JOINED. [EMBL / GenBank / DDBJ] [CoDingSequence] M63599; AAA59560.1; -. [EMBL / GenBank / DDBJ] [CoDingSequence]
PIR	A24153; MBHUB. S10482; S10482.
PDB	1QCL; 11-MAY-99. [ExPASy / RCSB]
SWISS-3DIMAGE	MBP_HUMAN.
MIM	159430. [NCBI / EBI]
GeneCards	MBP.
InterPro	IPR000548; -. Graphical view of domain structure.
Pfam	PF01669; Myelin_MBP; 1.
PRINTS	PR00212; MYELINMBP.
PROSITE	PS00569; MYELIN_MBP; 1.
PRODOM	[Domain structure / List of seq. sharing at least 1 domain]
BLOCKS	P02686.
DOMO	P02686.
PROTOMAP	P02686.
PRESAGE	P02686.
DIP	P02686.
SWISS-2DPAGE	GET REGION ON 2D PAGE.

Keywords

Myelin; Structural protein; Acetylation; Methylation; Phosphorylation; Autoimmune encephalomyelitis; Alternative splicing; 3D-structure.

Features

INIT_MET      0      0

MOD_RES       1      1       ACETYLATION.

MOD_RES     133    133       METHYLATION (MONO-:6% OR DI-:60%).

DOMAIN       45    114       INDUCES EXPERIMENTAL AUTOIMMUNE
                             ENCEPHALOMYELITIS IN MONKEYS, RABBITS,
                             AND RATS BUT NOT IN GUINEA PIGS.
DOMAIN      138    148       INDUCES EXPERIMENTAL AUTOIMMUNE
                             ENCEPHALOMYELITIS.
VARSPLIC     59     84       MISSING (IN 18.5 KDA ISOFORM
                             AND 17.2 KDA ISOFORM).
VARSPLIC    132    142       MISSING (IN 17.2 KDA ISOFORM).

Feature table viewer

Sequence information

Length: 196 AA

Molecular weight: 21362 Da

CRC64: 23E8D0C1CE689653 [This is a checksum on the sequence]

        10         20         30         40         50         60 
         |          |          |          |          |          | 
ASQKRPSQRH GSKYLATAST MDHARHGFLP RHRDTGILDS IGRFFGGDRG APKRGSGKVP

        70         80         90        100        110        120 
         |          |          |          |          |          | 
WLKPGRSPLP SHARSQPGLC NMYKDSHHPA RTAHYGSLPQ KSHGRTQDEN PVVHFFKNIV

       130        140        150        160        170        180 
         |          |          |          |          |          | 
TPRTPPPSQG KGRGLSLSRF SWGAEGQRPG FGYGGRASDY KSAHKGFKGV DAQGTLSKIF

       190    196 
         |      |
KLGGRDSRSG SPMARR

P02686 in FASTA format

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