Neurotransmitters and other chemical signalling agents
| DOPAMINE (DA) | |||
|---|---|---|---|
| Precursors: | Tyrosine (a) -> L-dihydroxyphenylalanine (L-DOPA) (b) -7gt; dopamine |
||
| Synthesising enzymes: | (a) Tyrosine hydroxylase; (b) L-aromatic amino-acid decarboxylase (DOPA decarboxylase) |
||
| Metabolising enzymes: | MAO and catechol-O-methyl transferase (COMT) | ||
| Metabolite: | 3,4-Dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) | ||
| Receptor subtypes | Agonists | Antagonists | Second messenger |
| D1 | SKF 38393 | Sch 23390 | (+ve) cAMP |
| D2 | Quinpirole | Sulpiride | (+ve)gK+ |
| D3 | 7-OH-DPAT | AJ-76 | ? |
| D4 | Dopamine | Clozapine | ? |
| D5 | Dopamine | Sch 23390 | (+ve)cAMP |
NB: (+ve) indicates increase; (-ve) indicates decrease.
Reviews
Sibley, D.R. (1991) Trends Pharmacol. Sci. 12, 7 - 9.
Van Tol, H.H.M. et al. (1991) Nature 350, 610 - 614.
Sunahara, R.K. et al. (1991) Nature 350, 614 - 619.
Endothelin
Cholecystokinin
Table of Contents
 |
 |
 |
 |
 |
 |
 |
 |