Neurotransmitters and other chemical signalling agents
| ENDOTHELIN (ET) | |||
|---|---|---|---|
| Precursors: | preproET-1 etc. | ||
| Synthesising enzymes: | "endothelin converting enzyme" | ||
| Metabolising enzymes: | not known | ||
| Receptor subtypes | Agonists | Antagonists | Second messenger |
| ET(A) | ET-1, ET-2 | FR139317, BQ123 | PI |
| ET(B) | Sarafotoxin S6C, [Ala(1),(3),(11),(15)] ET-1, BQ 3020 |
IRL 1038 | PI |
| ET(C) MB | |||
NB: (+ve) indicates increase; (-ve) indicates decrease.
Reviews
Sakurai, T., Yanagisawa, M. and Masaki, T. (1992) Trends Pharmacol. Sci. 13,
103-108.
Enkephalin and Dynorphin
Dopamine
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