Neurotransmitters and other chemical signalling agents
| ENKEPHALIN (met- and leu-) and DYNORPHIN | ||||
|---|---|---|---|---|
| Precursors: | Proenkephalin and prodynorphin | |||
| Synthesising enzymes: | Peptidases | |||
| Metabolising enzymes: | Enkephalinase (EC 24:11) and other peptidases | |||
| Metabolite: | Peptide fragments | |||
| Receptor subtypes | Agonists | Antagonists | Second messenger | |
| µ-opoid | DAGOL (DAMGO) | Naloxone | (-ve)cAMP, (+ve)gK+ | |
| delta-opoid | DPDPE | Naltrindol | (-ve)cAMP, (+ve)gK+ | |
| kappa-opoid | U69593, CI 977, dynorphin |
Norbinaltorphimine | (-ve)gCa2+ | |
Reviews
Kosterlitz, H.W. and Paterson, S.J. (1985) Phil. Trans. Roy. Soc. Lond. 308,
291-297. Millan, M.J. (1990) Trends Pharmacol. Sci. 11, 70-73.
Glutamate and Aspartate
Endothelin
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