Go to the abstract in the NAR 2001 Database Issue.
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Bader, G.D.2, Donaldson, I.5, Wolting, C.5, Ouellette, B.F.F.3, Pawson, T.2, Hogue, C.W.V.2
2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada M5G 1X5
3Centre for Molecular Medicine and Therapeutics, Children and Women's Health Centre of British Columbia, University of British Columbia, Vancouver, Canada V5Z 4H4
5MDS Proteomics, Inc. 251 Attwell Drive Toronto, Canada M9W 7H4
Contact gary.bader@utoronto.ca
The Biomolecular Interaction Network Database (BIND) is a database designed to store full descriptions of interactions, molecular complexes and pathways. Development of the BIND 2.0 data model has led to the incorporation of virtually all components of molecular mechanisms including interactions between any two molecules composed of proteins, nucleic acids, and small molecules. Chemical reactions, photochemical activation and conformational changes can also be described. Everything from small molecule biochemistry to signal transduction is abstracted in such a way that graph theory methods may be applied for data mining. The database can be used to study networks of interactions, to map pathways across taxonomic branches and to generate information for kinetic simulations. BIND anticipates the coming large influx of interaction information from high-throughput proteomics efforts including detailed information about post-translational modifications from mass spectrometry. Version 2.0 of the BIND data model is discussed as well as implementation, content and the open nature of the BIND project. The BIND data specification is available as ASN.1 and XML DTD.
BLAST vs. BIND now allows searching for similar biological sequences in BIND to a query sequence of interest. Newly updated web site.
Category Intermolecular Interactions
Go to the abstract in the NAR 2001 Database Issue.