EPConDB

http://www.cbil.upenn.edu/EPConDB

Pizarro, A.¹, Pinney, D.¹, Crabtree, J.¹, Mazzarelli, J.¹, Grant, G.¹, Le, P.¹, Manduchi, E.¹, McWeeney, S.¹, Scearce, M.², Brestelli, J.², Brownstein, B.³, Clifton, S.⁴, Inoue, H.⁵, Pape, D.⁴, Melton, D.⁶, Permutt, A.⁵, Kaestner, K.², Stoeckert, C.²

¹Center for Bioinformatics, University of Pennsylvania
²Dept. of Genetics, University of Pennsylvania School of Medicine
³Dept. of Genetics, Washington University in St. Louis School of Medicine
⁴Genome Sequencing Center, Washington University in St. Louis School of Medicine
⁵Division of Endocrinology, Metabolism and Diabetes, St. Louis, Missouri, USA , Washington University in St. Louis School of Medicine
⁶Dept. of Molecuar and Cellular Biology, Harvard University

Contact stoeckrt@pcbi.upenn.edu

Database Description

Genes expressed in the developing pancreas are the focus of EPConDB with a special emphasis on islet cells, the endocrine portion of the pancreas. Sources of gene expression data are ESTs from cDNA libraries and microarray experiments. Represented are all dbEST libraries from pancreatic tissues including those generated and sequenced by the laboratories of consortium members. Novel transcripts identified from the Consortium libraries are highlighted. Results of microarray experiments by consortium members are also provided. The EST and microarray experiment s have been used to design arrays that are enriched in genes expressed in pancreatic tissues; clones present on the array are provided on the site. The EST data are stored in GUS, the relational database that underlies PlasmoDB (http://plasmodb.org) and AllGenes (http://www.allgenes.org). Microarray data are stored in a sister relational database, RAD. Special features of the site include the ability to search for specific signal transduction pathways and to construct Boolean queries of chromosomal location, Gene Ontology function, dbEST library source, and tissue.

Acknowledgements

EPConDB is part of the NIDDK-sponsored consortium on "Functional Genomics of the Developing Endocrine Pancreas". We gratefully acknowledge support through NIDDK 56947 and 56954 with cosponsorship from the JDFI.