Go to the abstract in the NAR 2001 Database Issue.
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Contact wuc@nbrf.georgetown.edu
The iProClass database is an integrated resource that provides comprehensive family relationships at both global (whole protein) and local (domain and motif/site) levels, as well as structural/functional classifications and features of proteins. It currently consists of more than 270,000 non-redundant PIR and SwissProt proteins organized with more than 33,000 superfamilies, 100,000 families, 3400 domains, 1300 motifs, 280 post-translational modification sites, and links to over 40 databases of protein families, structures, functions, genes, genomes, literature, and taxonomy. Protein and superfamily summary reports provide rich annotations such as membership information with length, taxonomy, and keyword statistics, extensive cross-references, and graphical display of domain and motif regions. The iProClass employs a modular structure for scalability and extendibility, thereby providing a framework for integration of new data in a distributed networking environment. The database is implemented in Oracle 8i object-relational database system, and searchable by both sequence (BLAST search and peptide match) and text (unique identifiers and combinations of text strings). The integration of all the various family relationships facilitates comparative studies. Such knowledge is crucial to our understanding of protein evolution, structure, and function, and important for functional genomic and proteomic research.
Supported by NSF grant DBI-9974855
Category Protein Sequence Motifs
Go to the abstract in the NAR 2001 Database Issue.