Go to the abstract in the NAR 2000 Database Issue.
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Contact pirmail@nbrf.georgetown.edu
ProClass is a protein family database that organizes non-redundant sequence entries into families defined collectively by PIR superfamilies and ProSite patterns. By combining global similarities and functional motifs into a single classification scheme, ProClass helps to reveal domain and family relationships and classify multi-domain proteins. The database currently consists of more than 155,000 sequence entries retrieved from both PIR-International and SwissProt databases. Approximately 92,000 or 60% of the ProClass entries are classified into about 6,000 families, including a large number of new members detected by our GeneFIND family identification system. The ProClass motif collection contains about 72,000 motif sequences and over 1,300 multiple alignments for all ProSite patterns,including over 21,000 matches not listed in ProSite and mostly detected from unique PIR sequences. To maximize family information retrieval, the database provides links to various protein family,domain, alignment, and structural class databases. With its high classification rate and comprehensive family relationships, ProClass can be used to support full-scale genomic annotation. The database, now being implemented in an object-relational database management system, is available for on-line sequence search and record retrieval from our WWW server at http://pir.georgeown.edu/gfserver/proclass.html.
Category Protein Sequence Motifs
Go to the abstract in the NAR 2000 Database Issue.