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PROSITE

http://www.expasy.org/prosite

Falquet, L.1, Pagni, M.1, Bucher, P.2, Bairoch, A.3, Hulo, N.3, Sigrist, C.J.A.3, Hofmann, K.4

1Swiss Institute of Bioinformatics Ch. des Boveresses 155 CH-1066 Epalinges, Switzerland
2Swiss Institute for Experimental Cancer Reaserch Ch. des Boveresses 155 CH-1066 Epalinges, Switzerland
3Swiss Institute of Bioinformatics, CMU, University of Geneva, 1 rue Michel Servet, CH-1211 Geneva 4, Switzerland
43 MEMOREC, Stoffel GmbH Stoeckheimer Weg 1, D-50829 Koeln, Germany

Contact   laurent.falquet@isb-sib.ch


Database Description

The PROSITE database (http://www.expasy.org/prosite/) consists of biologically significant patterns and profiles designed in such a way that with appropriate computational tools it can help to determine to which known family of protein (if any) a new sequence belongs, or which known domain(s) it contains.

Recent Developments

The profile collection was extended with profiles for compositionally biased regions (e.g., PRO_RICH) and with so-called circular profiles that will produce one match for a repeat region consisting of several tandem repeated units (e.g., COLLAGEN_REP). A new Profile Scan server (http://hits.isb-sib.ch/cgi-bin/hits_motifscan) was created to provide an automatic weekly update of the collections (patterns, profiles, pfam-hmms) as well as a link to the Hits databases (http://hits.isb-sib.ch)

Acknowledgements

PROSITE is funded by grants from the Swiss federal government.

REFERENCES

  1. Falquet, L., Pagni, M., Bucher, P., Hulo, N., Sigrist, C.J.A., Hofmann, K., Bairoch, A. The PROSITE database, its status in 2002. Nucleic Acids Res. 30 (2002), submitted.

Category   Protein Sequence Motifs

Go to the abstract in the NAR 2002 Database Issue.

 

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