Nuclc. Acids. Res. OUP
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH ARTICLES TABLE OF CONTENTS
Compilation Paper
Categories List
Alphabetical List
Search Summary Papers

The HugeIndex: Human Gene Expression Index

http://www.hugeindex.org

Haverty, P.1, Weng, Z.2, Best, N.3, Auerback, K.3, Hsiao, L.3, Jensen, R.4, Gullans, S.3

1Bioinformatics Program, Boston University, Boston, Massachusett
2Department of Biomedical Engineering, Boston University, Boston, Massachusett
3Departments of Medicine and Neurology, Brigham and WomenÌs Hospital, Harvard Medical School, Boston, Massachuset
4Department of Physics, Wesleyan University, Middletown, Connecticu

Contact   zhiping@bu.edu


Database Description

High-density oligonucleotide arrays are a powerful tool for uncovering changes in global gene expression in various disease states. To this end, it is essential to first characterize the variations of gene expression in normal physiological processes. We established the Human Gene Expression (HuGE) Index database (www.HugeIndex.org) to serve as a public repository for gene expression data on normal human tissues using high-density oligonucleotide arrays. This resource currently contains the results of 59 gene expression experiments on 19 human tissues. We provide interactive tools for researchers to query and visualize our data over the Internet. To facilitate data analysis, we cross-reference each gene on the array with its annotation in the LocusLink d

REFERENCES

  1. Lockhart, D.J. and Winzeler, E.A. (2000) Nature, 405, 827-836.
  2. DeRisi, J., Penland, L., Brown, P.O., Bittner, M.L., Meltzer, P.S., Ray, M., Chen, Y., Su, Y.A. and Trent, J.M. (1996) Nat Genet, 14, 457-460.
  3. Golub, T.R., Slonim, D.K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J.P., Coller, H., Loh, M.L., Downing, J.R., Caligiuri, M.A. et al. (1999) Science, 286, 531-537.
  4. Alizadeh, A.A., Eisen, M.B., Davis, R.E., Ma, C., Lossos, I.S., Rosenwald, A., Boldrick, J.C., Sabet, H., Tran, T., Yu, X. et al. (2000) Nature, 403, 503-511.
  5. Alon, U., Barkai, N., Notterman, D.A., Gish, K., Ybarra, S., Mack, D. and Levine, A.J. (1999) Proc Natl Acad Sci U S A, 96, 6745-6750.
  6. Svaren, J., Ehrig, T., Abdulkadir, S.A., Ehrengruber, M.U., Watson, M.A. and Milbrandt, J. (2000) J Biol Chem.
  7. Lockhart, D.J., Dong, H., Byrne, M.C., Follettie, M.T., Gallo, M.V., Chee, M.S., Mittmann, M., Wang, C., Kobayashi, M., Horton, H. et al. (1996) Nat Biotechnol, 14, 1675-1680.
  8. Hsiao, L., Yoshida, T., Hong, R., Jensen, R., Dangond, F., Misra, J., Haverty, P., Weng, Z., Mutter, G., Milford, E.L. et al. (Accepted) Physiological Genomics.
  9. Visual Mining, I. (2001). 3.7 ed, Rockville.
  10. Pruitt, K.D. and Maglott, D.R. (2001) Nucleic Acids Res, 29, 137-140.

Category   Gene Expression

 

Compilation Paper
Categories List
Alphabetical List
Search Summary Papers