Go to the abstract in the NAR 2001 Database Issue.
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Contact jpon@bionet.nsc.ru
ACTIVITY is a database on DNA/RNA site sequences with known activity magnitudes, measurement systems, sequence-activity relationships revealed at fixed experimental conditions, and procedures adapting the application of these relationships from one measurement system to another. This database deposits the information on DNA/RNA affinities to proteins and cell nuclear extracts, cutting efficiencies, gene transcription activity, mRNA translation efficiencies, mutability, and some other biological activities of natural sites occurring within promoters, mRNA leaders, and other regulatory regions in pro- and eukaryotic genomes, their mutant forms and synthetic analogues. Since activity magnitudes are heavily system-dependent, the presented version of ACTIVITY is supplemented by three novel sub-databases: (i) SYSTEM, measurement systems; (ii) KNOWLEDGE, sequence-activity relationship in experimental conditions fixed; and (iii) CROSS_TEST, procedures adapting a relationship from one measurement system to another. These databases are useful in molecular biology, pharmacogenetics, metabolic engineering, drug design, and biotechnology. The databases are SRS-queried and available through the Web, http://wwwmgs.bionet.nsc.ru/systems/Activity/.
Category RNA Sequences
Go to the abstract in the NAR 2001 Database Issue.