Go to the abstract in the NAR 2001 Database Issue.
 |
 |
|||||||
|
||||||||
1Department of Medical Biochemistry, University of Gˆteborg, Box 440, SE-405 30 Gˆteborg, Sweden
2Department of Molecular Biology, The University of Texas Health Science Center at Tyler, 11937 US Highway 271, Tyler, TX 75708-3154, U.S.A.
Contact zwieb@uthct.edu
Signal recognition particle (SRP) is an ribonucleoprotein particle designed to recognize secretory signal sequences as they emerge from the ribosome. SRP associates with the SRP-receptor in the ER membrane, is released from the ribosome, and recycled (for review, see [1]). To help in understanding the molecular details of this essential cellular function, the SRP database (SRPDB) provides sequences of SRP RNA, SRP proteins, and the SRP receptor ordered alphabetically and phylogenetically with links to the primary sources, as well as a manually-checked alignments. The SRP RNA alignment serves to derive phylogenetically-supported secondary structures and to evaluate potential tertiary interactions. The SRPDB is maintained at the University of Texas Health Science Center at Tyler, Texas, accessible on the World Wide Web at the URL http://psyche.uthct.edu/dbs/SRPDB/SRPDB.html and at the European mirror at the University of Gˆteborg, Sweden (http://bio.lundberg.gu.se/dbs/SRPDB/SRPDB.html). SRPDB is updated regularly at least once a year.
Archaeal SRP components have been updated recently. Numerous new sequences from the other phylogenetic domains will be added by the end of 2001. A tool to identify SRP RNA genes in genome sequences and to display potential secondary structure of these genes has been developed and a web interface to this tool will be available early in 2002.
This work is supported by NIH grant GM-49034 to C. Zwieb
Category RNA Sequences
Go to the abstract in the NAR 2001 Database Issue.