Go to the abstract in the NAR 2000 Database Issue.
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Contact oke@biobase.de
The COMPEL database is devoted to the particular aspect of gene transcriptional regulation. It contains information about composite elements - the basic structures of combinatorial gene regulation. Composite regulatory elements consist of two closely situated binding sites for distinct transcription factors, and represent minimal functional units providing combinatorial transcriptional regulation. Both specific factor-DNA and factor-factor interactions contribute to the function of composite elements. Information about the structure of known composite elements and specific gene regulation achieved through such composite elements appears to be extremely useful for promoter prediction, for gene function prediction and for applied gene engineering as well. The structure of the relational model of COMPEL is determined by the concept of molecular structure and regulatory role of composite elements. The COMPEL database equipped with the search and browse tools is available at http://compel.bionet.nsc.ru/ and http://www.gene-regulation.com/databases.html#compel. A program for searching potential composite elements in DNA sequences has been developed. A sequence under study is scanned by this program using all composite elements collected in the COMPEL as individual searching patterns. All found matches are directly linked to the COMPEL entries containing the corresponding composite elements. The program for searching potential composite elements is available at http://compel.bionet.nsc.ru/FunSite/CompelPatternSearch.html and http://gene.gene-regulation.com/programs/pub/CompelPatternSearch/index.html.
Category Gene Identification and Structure
Go to the abstract in the NAR 2000 Database Issue.