Nuclc. Acids. Res. OUP
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LocusLink/RefSeq

http://www.ncbi.nlm.nih.gov/LocusLink/

Pruitt, K.D, Maglott, D.R.

National Center for Biotechnology Information NLM/NIH Bldg. 38A Rm 6N605 8600 Rockville Pike Bethesda, MD 20894 USA

Contact   pruitt@ncbi.nlm.nih.gov


Database Description

RefSeq provides curated non-redundant sequence standards for genomic regions, transcripts (including splice variants), and proteins. The scope includes small genomes, human, mouse, and rat. RefSeq standards provide a foundation for the functional annotation of the human genome. They provide a stable reference for gene characterization, mutation analysis, expression studies, and polymorphism discovery. RefSeq sequence records incorporate some of the descriptive data available in LocusLink; nucleotide records include computed variation annotation and protein records include computed domain annotation. Additional information including sequence extensions, corrections, and brief gene summaries are provided through an ongoing manual review process. LocusLink provides descriptive information about genes and loci including nomenclature, disease associations, map data, database identifiers, GO terms, sequence associations, and computed domains. LocusLink provides extensive cross-links to additional sources of information including the NCBI Map Viewer, OMIM, UniGene, HomoloGene, mutation databases, and many more. The scope includes human, mouse, rat, fly, and zebrafish. Together, RefSeq and LocusLink provide data on genes and other loci that supports research on genes and gene families, variation, gene expression, and genome annotation. Additional information about both RefSeq and LocusLink is available at http://www.ncbi.nlm.nih.gov/LocusLink/.

Recent Developments

A new type of RefSeq record representing larger genomic regions are provided for select regions. These records have the accession prefix "NG_". LocusLink added Gene Ontology (GO) terms to human, mouse, and fly reports. Links were added to access the computed human-mouse homology map. The web interface has been updated to support selecting multiple reports to display and download, and links to display mRNA-to-genomic alignments are provided.

REFERENCES

  1. Pruitt KD, Maglott DR. (2001) RefSeq and LocusLink: NCBI gene-centered resources. Nucleic Acids Res., 29, 137-140.
  2. Pruitt KD, Katz KS, Sicotte H, Maglott DR. (2000) Introducing RefSeq and LocusLink: curated human genome resources at the NCBI. Trends Genet., 16, 44-47.

Category   Varied Biomedical Content

Go to the abstract in the NAR 2001 Database Issue.

 

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