Homophila

http://homophila.sdsc.edu

Gribskov, M.¹, Bier, E.², Reiter, L.T.³, Chien, S.⁴

¹San Diego Supercomputer Center & Dept of Biology University of California, San Diego 9500 Gilman Dr. La Jolla CA 92093-0537
²Dept. of Biology University of California, San Diego 9500 Gilman Dr. La Jolla CA 92093-0349
³Dept. of Biology University of California, San Diego 9500 Gilman Dr. La Jolla CA 92093-0349
⁴San Diego Supercomputer Center & Dept. of Biology University of California, San Diego 9500 Gilman Dr. La Jolla CA 92093-0537

Contact gribskov@sdsc.edu

Database Description

Although many human genes have been associated with disease phenotypes, knowing the mutations in one or several disease genes often does not explain the etiology of a specific disease. Drosophila melanogaster provides a powerful system in which to use genetic and molecular approaches to investigate human genetic disease. Homophila is an intergenomic resource linking the human and fly genomes in order to provide a tool for planning functional genomic investigations in Drosophila that address questions about genetic disease in humans. Homophila is a relational database that allows searching based on human disease descriptions, fly phenotypes, human or fly gene names and sequence similarity. Homophila provides a comprehensive linkage between the disease genes compiled in Online Mendelian Inheritance in Man and the complete Drosophila genomic sequence. Homophila is available at http://homophila.sdsc.edu.

Acknowledgements

This work supported in part by the National Institutes of Health through grant through a National Center for Research Resources program grant (P 41 RR08605-06) to the National Biomedical Computation Resource at the San Diego Supercomputer Center.

REFERENCES

Reiter, LT; Potocki, L; Chien, S; Gribskov, M; Bier, E. (2001) A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome Research, 11:1114-1125.