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HAMAP families

HIGH-QUALITY AUTOMATED AND MANUAL ANNOTATION OF MICROBIAL PROTEOMES
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The HAMAP families are a collection of orthologous microbial protein families, generated manually by expert curators. They are used for the high-quality automatic annotation of microbial proteomes in the framework of the Swiss-Prot protein knowledgebase. Each family is composed of the following data:
  • Annotation that is propagated to member entries (e.g. protein name, keywords).
  • Computed features (e.g. export signals, transmembrane regions) that may be applied to entries by using appropriate prediction programs.
  • Alignments of a representative set of entries. There is usually a single alignment per family, unless there is a 'deep split' between bacterial and archaeal entries.
  • Profiles in PROSITE format that are automatically generated from the alignments and serve for the identification of new members in complete microbial proteomes.
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Statistics
(Last update: 03-Apr-2003)
Number of families: 755
      (800 alignments/profiles)
By taxonomic scope:
      Archaea: 106
      Bacteria: 332
      Archaea+Bacteria: 223
      Bacteria+Plastid: 58
      Bacteria+Firmicutes: 1
      Actinobacteria+Bacteria: 2
      Arch.+Bact.+Plas.: 22
      Bacteria+Enterobacteriaceae: 9
      Baci.+Bact.+Clos.: 1
      Arch.+Bact.+Ther.: 1
Coverage:
      24838 Swiss-Prot entries
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