Mycobacterium leprae

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Species: Mycobacterium leprae

Species code: MYCLE

Type: Eubacteria

Taxonomy: Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium (TaxID: 1769) [NEWT / NCBI]

Strain(s): TN

Genome: circular, 3.27 Mb; no ECE

Reference(s): MEDLINE=21128732 [NCBI, ExPASy, Israel, Japan]; PubMed=11234002;
Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C., Harris D., Mungall K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G.;
"Massive gene decay in the leprosy bacillus.";
Nature 409:1007-1011(2001).

Genome official sequence WWW site(s): http://www.sanger.ac.uk/Projects/M_leprae/

Other WWW site(s): Leproma
GIB (DDBJ)
TIGR CMR
EBI GeneQuiz

Description: Acid-fast, obligate intracellular pathogen, non-motile, rod-shaped bacterium. It is responsible for leprosy. It reproduces very slowly and affects skin, nerves and mucous membranes.

Before the 1940's leprosy was considered incurable until the development of the drug dapsone. M.leprae has however started to develop resistance to dapsone and so a new multiple-drug therapy (MDT) containing three drugs: dapsone, rifampicin and clofazimine is administered.

Properties: Number of membranes : 1
Presence of a flagella : No
Number of inteins : 4 in 4 different sequences

Genomic Proximity Viewer
Proteome analysis at EBI
Perform a BLAST search against all proteins from Mycobacterium leprae
Download ftp file containing all Swiss-Prot and TrEMBL entries of this organism
- in Swiss-Prot format
- in FASTA format

Last modified 12-Apr-2003

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Species:	Mycobacterium leprae
Species code:	MYCLE
Type:	Eubacteria
Taxonomy:	Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium (TaxID: 1769) [NEWT / NCBI]
Strain(s):	TN
Genome:	circular, 3.27 Mb; no ECE
Reference(s):	MEDLINE=21128732 [NCBI, ExPASy, Israel, Japan]; PubMed=11234002; Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C., Harris D., Mungall K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G.; "Massive gene decay in the leprosy bacillus."; Nature 409:1007-1011(2001).
Genome official sequence WWW site(s):	http://www.sanger.ac.uk/Projects/M_leprae/
Other WWW site(s):	Leproma GIB (DDBJ) TIGR CMR EBI GeneQuiz
Description:	Acid-fast, obligate intracellular pathogen, non-motile, rod-shaped bacterium. It is responsible for leprosy. It reproduces very slowly and affects skin, nerves and mucous membranes. Before the 1940's leprosy was considered incurable until the development of the drug dapsone. M.leprae has however started to develop resistance to dapsone and so a new multiple-drug therapy (MDT) containing three drugs: dapsone, rifampicin and clofazimine is administered.
Properties:	Number of membranes : 1 Presence of a flagella : No Number of inteins : 4 in 4 different sequences