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The ExPASy Molecular Biology Server

History of changes, improvements and new features

If you subscribe to our Swiss-Flash service of electronic bulletins, you can receive these and other news by electronic mail.

March 21, 2003
New cross-references have been introduced in Swiss-Prot:

There is a new Swiss-Prot document, arath.txt - Index of Arabidopsis thaliana entries and their corresponding gene designations.

An interface to PRATT has been implemented on ExPASy. PRATT is a tool to discover patterns that are conserved in a set of protein sequences. The patterns are reported using the PROSITE format. The ExPASy BLAST result representation has been modified to allow direct submission of a number of sequences to PRATT.

The ExPASy BLAST interface now allows to perform tblastn searches against individual microbial genomes (EMBL genome records, including plasmids).

Throughout the ExPASy server, the navigation bar at the top of every page now includes a search bar, for quick access to Swiss-Prot, TrEMBL, PROSITE, SWISS-2DPAGE, ENZYME, Taxonomy, HAMAP and ExPASy site search.

November 19, 2002
We are happy to announce a new ExPASy mirror site in Bolivia, http://bo.expasy.org, hosted by the Universidad Católica Boliviana in Cochabamba.

October 25, 2002
ExPASyBar, a very useful navigation bar to the most important databases and tools on the ExPASy server, has been developed by Martin Hassman, with input from the ExPASy team. ExPASyBar is an add-on to the Mozilla web browser (i.e. it does not work with Netscape, MS Internet Explorer and other browsers). Installation is very simple. ExPASyBar can be configured to use the ExPASy mirror of the user's choice (in the Edit/Preferences/Advanced/ExPASyBar menu of Mozilla).

August 27, 2002
The last "What's new on ExPASy" is more than a year old, which means that some of the changes and "new" features and services are not all that new anymore.... We are trying to list here the most important changes, and we will try to report new tools and documents again more frequently in the future!

=== ExPASy ===

=== TOOLS ===

Two tools have been added to our collection of sequence analysis and proteomics tools:

Major updates have been performed on two tools:

=== SWISS-PROT ===

=== SWISS-2DPAGE ===

New cross-references, reference maps, and a document have been added:

June 30, 2001
New cross-references have been added from relevant SWISS-PROT entries to three databases:

The keyword "Complete proteome" has been introduced to all SWISS-PROT/TrEMBL entries describing a protein which is thought to be expressed by an organism whose genome has been completely sequenced. This keyword is so far only used for microbial (bacterial and archaeal) proteins. A complete set of proteins from a microbial genome can therefore be obtained using this keyword across SWISS-PROT and TrEMBL.

A new and improved version of the NiceProt view of SWISS-PROT is available (example). Some of its new features are:

SWISS-PROT release statistics are now available for every update of the database. Among other parameters, statistics about database growth, average sequence lengths and amino acid composition, taxonomic origin, journal citations and database cross-references are presented, including some graphics.

A new view is available within the SRS Sequence Retrieval System. It displays, for each protein corresponding to a user query, gene name(s) and organism (in addition to the parameters ID, AC, description and sequence length which are displayed by the default view "Short description"). This new view is entitled "Long description" and is available from the menu "Use view ..." in the SRS query form.

The SIB Blast interface (accessible also via "Quick BLAST" or from the bottom of every SWISS-PROT/ TrEMBL entry) now offers the possibility to restrict the similarity search by using taxonomic criteria. A "Taxonomic View" of the results can also be obtained via the BLAST result page.

L'équipe Swiss-Prot a le plaisir de vous présenter le premier article de "Protéines à la Une", sa nouvelle rubrique de vulgarisation scientifique dédiée aux protéines qui font parler d'elles dans l'actualité.

January 18, 2001
    New cross-references have been added to three additional databases:
    • GlycoSuiteDB - a database of glycan structures; explicit links
      example: P00750
    • GeneCensus - a compilation of ORF data for the Saccharomyces genome; implicit links
      example: Q01802
    • HUGE - a database of human unidentified gene-encoded large proteins; implicit links
      example: P42330

  • NiceProt & SIB BLAST The NiceProt view of SWISS-PROT/TrEMBL entries now contains a direct submission button requesting a blastp homology search of the protein against SWISS-PROT/TrEMBL/TrEMBLnew, on the SIB BLAST server ("Quick BlastP search"). In the results of SIB BLAST searches on ExPASy (normal or "NiceBlast" output formats), the user can select a number of matching sequences and directly submit them to a ClustalW search, or retrieve and download the corresponding SWISS-PROT/TrEMBL entries.

  • Proteomics tools
    • FindPept: This new tool can identify peptides that result from unspecific cleavage of proteins from their experimental masses, taking into account artefactual chemical modifications, post-translational modifications (PTM) and protease autolytic cleavage.
    • PeptIdent: Several new features have been added.
      • When searching SWISS-PROT, all alternative splice isoforms described in SWISS-PROT feature tables are included in the search (e.g. Isoform 12S of O43184).
      • New organism classes can be searched. For each of the available taxonomic available (e.g. Mammalia), a new section (e.g. other Mammalia) has been added, which comprises all entries not corresponding to any of the searchable subclasses (e.g. all Mammalia except human, bovine, rabbit, and other rodents).
      • For each matching protein in a PeptIdent result, buttons are available which allow further analysis of the protein by direct submission of the data to FindMod, FindPept, GlycoMod, PeptideMass and BioGraph.
    • GlycoMod: Possible oligosaccharide structures suggested by GlycoMod are linked to the GlycoSuiteDB database of glycan structures, if they are reported in this database. The user can also select to display compositions reported in GlycoSuiteDB separately from the compositions not known in the database.
  • October 28, 2000

    April 26, 2000

    October 4, 1999

    June 16, 1999
    The 'Nice' view tools for the databases provided on ExPASy (SWISS-PROT, SWISS-2DPAGE, PROSITE, ENZYME) have been developed in order to provide users with an easily readable alternative to the original text file representation.

    The following tools are available:

    Database       Tool       Example
    SWISS-PROT     NiceProt   http://www.expasy.ch/cgi-bin/niceprot.pl?P14060
    SWISS-2DPAGE   Nice2DPage http://www.expasy.ch/cgi-bin/nice2dpage.pl?P00938
    PROSITE        NiceSite   http://www.expasy.ch/cgi-bin/nicesite.pl?PS00661 
    ENZYME         NiceZyme   http://www.expasy.ch/cgi-bin/nicezyme.pl? 
    We have now changed all our tools and database search programs on ExPASy to display the 'Nice' version of a database entry by default. The programs displaying database entries in their original text formats continue to be maintained, and links are available from the 'Nice' views to the corresponding get-xxx-entry programs (e.g. get-sprot-entry).

    If you maintain pages with links to entries from the above-mentioned databases, you might be interested to update these links to use the 'Nice' View if you prefer this representation to the original format. Otherwise you are, of course, completely free to keep the get-xxx-entry links.

    May 24, 1999

    February 26, 1999

    October 27, 1998

    August 24, 1998

    June 13, 1998

    March 27, 1998

    February 13, 1998

    January 13, 1998

    November 27, 1997

    October 7, 1997

    September 5, 1997
    Some new features of ExPASy:

    July 24, 1997
    We have now an SRS server (version 5) running on ExPASy. SRS (Sequence Retrieval System) allows you to retrieve entries across multiple databases with more sophisticated criteria than those allowed by the text-search interfaces available from the SWISS-PROT top page.

    You can combine all the fields with logical operators and achieve queries like:

    Five databases are indexed: SWISS-PROT, TrEMBL, TrEMBL_NEW, PROSITE, and ENZYME. SWISS-PROT and TrEMBL are updated on a weekly basis so that the set of these two databases stays non-redundant.

    TrEMBL entries are now fully accessible on ExPASy via a cgi-script. The hypertext version of TrEMBL contains links to various databases and allows direct access to sequence analysis tools such as Swiss-Model, Blast, ProtParam, ProtScale, Compute pI/Mw and PeptideMass, as is the case for SWISS-PROT.

    If you wish to link to a TrEMBL entry, you can use the following URL:

    e.g. to create a link to TrEMBL entry Q00061, use:

    June 6, 1997
    We are actively seeking any type of updates and/or corrections of SWISS-PROT entries, whether they have been published or not, and we encourage our users to submit us their suggested updates or corrections. This can be done using our new submission form, which can be accessed through an active link from the SWISS-PROT home page or from the bottom of each SWISS-PROT entry. Please read the tips and guidelines to find out what type of information we are seeking and how to proceed. We would already like to thank our users in advance for any contribution they can make in updating and correcting SWISS-PROT!

    The tool which allows you to visualize and highlight the subsequence corresponding to a line in a SWISS-PROT feature table (FT) has been improved and is now using colour to highlight the subsequences in question. Example: in FA9_HUMAN:

    FT   DOMAIN       93    129       EGF-LIKE 1, CALCIUM-BINDING (POTENTIAL).

    May 21, 1997
    At the bottom of each page displaying a SWISS-PROT entry, you will now find a link to a graphical Feature Table viewer (Java Applet) written by Thomas Junier at the Bioinformatics Group of ISREC Lausanne.

    We have added several new hyperlinks in SWISS-PROT entries:
  • The DR lines containing cross-references to EMBL/GenBank/DDBJ now include a link to a page displaying exclusively the corresponding CoDing Sequence (CDS).
  • The RL lines referring to recent articles in certain journals whose WWW servers are maintained in collaboration with HighWire Press are now active hyperlinks to the abstracts of the corresponding articles. From the abstract page you can frequently access directly a full text on-line version of the article. The journals include J. Biol. Chem., Proc. Natl. Acad. Sci. USA, Science, Cell, etc.
  • Entries with cross-references to MIM are now also linked (through a new virtual "DR GeneCards" line) to GeneCards, a database integrating information about the functions of human genes and their products, and of biomedical applications based on this knowledge.
    Example: BRC1_HUMAN.
  • Entries belonging to family 1 of G-protein coupled receptors (as documented in feature tables) now contain active links to GPCRDB-Snakes diagrams (through the new virtual "DR GPCRDB-Snakes" line) prepared by the GPCRDB group at EMBL Heidelberg.
    Example: 5H1A_HUMAN.
  • There are 3 new SWISS-PROT documents:
  • humchr19.txt: an index of protein sequence entries encoded on human chromosome 19
  • ngr234.txt: a table of putative genes in Rhizobium plasmid pNGR234a
  • initfact.txt: a list of translation initiation factors
  • On the ExPASy anonymous FTP server, the SWISS-PROT update files new_seq.dat, upd_ann.dat and upd_seq.dat are now also available in compressed form in the directory /ftp/databases/swiss-prot/updates_compressed/.

    March 27, 1997
    We have modified and improved access from ExPASy to various BLAST (Basic Local Alignment Search Tool) similarity search services:

    In the tools page, you can now choose between 5 different interfaces to BLAST servers in Switzerland, the USA and Germany:

    Running on a 2-processor Pentium Pro machine, the new WU-BLAST server at EMBNet Switzerland in Lausanne has a faster response time than the EPFL server, and should be more stable. As opposed to the original NCBI BLAST algorithm, WU-BLAST generates gapped alignments. A full set of weekly updated databases is provided.
    USA: Germany:

    For direct BLAST submission from a SWISS-PROT entry (icons at the bottom of the page displaying an entry - example), you have the choice between the servers at NCBI and EMBNet-CH.

    The following documents have been added to the list of SWISS-PROT documents:

    March 17, 1997
    We have completely rewritten the Swiss-Shop sequence alerting system for SWISS-PROT that allows you to automatically obtain (by email) new sequence entries relevant to your field(s) of interest.

    In the new version of Swiss-Shop, some new features have been added:

    As before, you can either launch a sequence/pattern based search or a keyword based search.

    Furthermore, we now offer you 4 different output formats. You can choose to receive the sequences matching your query

    You can further specify if you wish to be notified every time Swiss-Shop is run, even if there are no new sequences matching your query, or to receive an email report only when there are new SWISS-PROT entries matching your search terms.
    You can specify the expiration date of your request, the default being one year after submission.
    For editing previous requests (e.g. to update the expiration date or to modify search criteria) you can enter a password for each new request. This allows you to open the request later and edit it on-line rather than deleting it and submitting a new one.

    March 6, 1997
    New and improved protein identification tools:

    March 4, 1997
    Thanks to the generosity of the Geneva Government, we have been able to acquire a new computer for the ExPASy server (a Sun Microsystems Ultra Server Enterprise 2). The server is now accessible at URL:


    The old URL remains valid for some time.

    January 9, 1997
    Some new features of ExPASy:

    November 26, 1996
    The Boehringer Mannheim Biochemical Pathways maps and index have been digitised and are now accesible on this server. Enter a keyword (such as, for example Oxoacyl) and surf on the biochemical pathways maps.

    November 11, 1996
    CD40Lbase, The European CD40L Defect Database prepared by Manuel Peitsch, has been made accessible through this server. The purpose of CD40Lbase is to collect clinical and molecular data on CD40 ligand defects leading to X-linked Hyper-IgM syndrome.

    A new tool is available from the Tools page: The PeptideMass Peptide Characterisation Software. This program is designed to calculate the theoretical masses of peptides generated by the chemical or enzymatic cleavage of proteins, to assist in the interpretation of peptide mass fingerprinting and peptide mapping experiments. Protein sequences can be provided by the user or can be a code name for a protein in the SWISS-PROT protein database. When proteins of interest are specified from SWISS-PROT, the program considers all annotations for that protein in the database, and uses these in order to generate the correct peptide masses and warn users about peptides that are not likely to be found when undertaking peptide mass fingerprinting. Many protein post-translational modifications which affect the masses of peptides can thus be taken into consideration.

    In PROSITE and Enzyme, we have added the possibility to save all referenced SWISS-PROT entries to a file on our anonymous FTP server (in the outgoing directory).

    The Compute pI/Mw tool has been included in the list of sequence analysis tools that can be directly accessed from a SWISS-PROT entry.

    Two new SWISS-PROT documents are available:
    - humchr20.txt - an index of protein sequence entries encoded on human chromosome 20
    - tisslist.txt - a list of the currently valid values for the "TISSUE" topic of the RC line type in SWISS-PROT.

    September 30, 1996
    A new SWISS-PROT document has been added: ribosomp.txt - an index of ribosomal proteins classified by families on the basis of sequence similarities.

    In ec2dtosp.txt, an index of E. coli Gene-protein database (ECO2DBASE) entries referenced in SWISS-PROT, we have established direct links to ECO2DBASE, and SWISS-PROT entries now also contain links to ECO2DBASE.

    At the end of each page displaying a SWISS-PROT entry we have added links to our sequence analysis tools ProtParam and ProtScale,which allows the user to directly submit the SWISS-PROT sequence to these tools.

    September 19, 1996
    Some new features of ExPASy:

    April 11, 1996
    AACompIdent: New options - AACompIdent is a tool which allows the identification of a protein from its amino acid composition. It searches SWISS-PROT for proteins, whose amino acid compositions are closest to the amino acid composition given. Two new options and a new constellation have been added to this tool:

    A. C-Terminal display in tagging option

    The user may now choose between displaying the C or N terminal side of the proteins that score best.

    B. Permutation search in tagging option

    This option searches for all permutations of the given tag in the sequences.

    C. Constellation 4

    Constellation 4 has been added: Ala, Ile, Pro, Val, Arg, Leu, Ser, Asx, Lys, Thr, Glx, Met, His, Phe and Tyr. (Asp+Asn=Asx; Gln+Glu=Glx; Gly, Cys and Trp are not considered).

    March 22, 1996
    We have added a new tool, ProtScale which allows you to compute and represent the profile produced by an amino acid scale on a selected protein. 50 scales are provided, including 'classics' such as the Kyte and Doolittle hydrophobicity scale.

    Links have been added between relevant SWISS-PROT entries and the 2D gel protein databases at Harefield.

    A new SWISS-PROT document has been added which describes the nomenclature of glycosyl hydrolases (GH) and that includes an index of sequences that belong to the various GH families.

    A PC (MS-Windows) version of LALNVIEW (graphical viewer for pairwise alignments) is now available.

    Nicolas Guex has produced a new logo for PROSITE.

    February 16, 1996
    We have added a new tool, SIM which computes a user defined number of best non-intersecting alignments between two sequences. The results of the alignment can be viewed graphically using the LALNVIEW program developed by Laurent Duret and which is currently available for Macs and UNIX.

    Additional links have been added in the tools page, notably to the Weizmann Institute ultra-fast rigorous (Smith/Waterman) similarity searches using the Bioccelerator and to the Garnier, Osgoodthorpe and Robson (GOR) secondary structure prediction method at SBDS.

    The SeqAnalRef database now includes a section listing author's email and eventually also WWW home pages. It is also possible to access the links from a page displaying either a reference list or a single reference.

    Amos has recently started to create a list of Biomolecular servers for his own usage, but as some people have asked to access this list (which is under construction), we are making it available from the ExPASy top page. Many other small changes were carried out in the last two months.

    We thank you for using ExPASy (we have now reached a cumulative total of 4 million connections).

    December 14, 1995
    After 29 months of existence the ExPASy molecular biology server received a new logo, designed and produced by Nicolas Guex.

    October 23, 1995
    The Melanie page has been reorganised. With the announcement of release 2.1 of the Melanie II 2-D PAGE analysis software package, a complete up-to-date description of the software as well as a comprehensive tutorial are now available.

    October 13, 1995
    Links have been added between SWISS-PROT Escherichia coli K12 chromosomal entries and the EcoCyc database, the encyclopedia of E. coli Gene and Metabolism.

    You can now seach in PROSITE by citation.

    October 9, 1995
    Some new features of ExPASy:

    Many other changes have been done, such as the redesign of the Geneva local pages; the addition, in the tool page, of a link to ProfileScan.

    It should also be noted that when you search in SWISS-PROT by either description or by full text and that your seach criteria returns more than two entries, you can save these entries to a file on our anonymous FTP server (in the outgoing directory).

    September 19, 1995
    AACompIdent: New options - AACompIdent is a tool which allows the identification of a protein from its amino acid composition. It searches SWISS-PROT for proteins, whose amino acid compositions are closest to the amino acid composition given. A new option and a new constellation have been added to this tool:

    A. Tagging option

    With this option, the first 40 amino acid of each protein are printed in the result, instead of the protein name. One may optionnally also enter a tag (a short seuqnece, typically 3 to 8 residues) which will be matched with the sequences of the resulting proteins. Proteins matching the tag will be marked.

    B. Free constellation

    This is a free constellation, that is one may select any amino acid constellation he/she likes. One just have to fill in the composition values for the selected amino acids. The values will then be normalised, so that the total make 100 (percent).

    September 4, 1995
    A new page has been created: WORLD-2DPAGE is an index to all known federated 2-D PAGE database servers, as well as to 2-D PAGE related servers and services.

    July 22, 1995
    A new tool has been implemented on ExPASy, ProtParam allows the computation of various physical and chemical parameters for a given protein stored in SWISS-PROT or for a user entered sequence. The computed parameters include the molecular weight, theoretical pI, amino acid composition, extinction coefficient, estimated half-life, instability index and aliphatic index

    The Journal of Biological Chemistry (JBC) has a WWW server where abstracts and full text of articles are made available. We are happy to announce the implementation of what we believe to be the first direct link in a sequence database between a reference and the full text version of a cited article. Recent JBC references are directly linked to the corresponding entry point in the JBC server. If you want to see such a link, take a look at reference 3 in SWISS-PROT entry KDSA_ECOLI.

    The SWISS-PROT document file jourlist.txt which provides information on all the journals cited in that database, now contains links to WWW or Gopher servers set up by a variety of publishers of academic journals.

    Two new SWISS-PROT document have been added, one is a nomenclature and index of peptidase sequences, the other is the list of Yeast Chromosome VI entries in SWISS-PROT

    June 19, 1995
    A new tool has been implemented on ExPASy, ScanProsite allows to either scan a protein sequence the occurence of patterns stored in the PROSITE database or to scan the SWISS-PROT database - including weekly releases - for the occurence of a pattern.

    We are happy to announce a new ""service"" Swiss-Quiz The principle of this quiz is to answer to 10 randomly chosen questions relative to the fields of molecular biology, biochemistry and genetics. Each month, we will randomly pick up one person among all those that have obtained a perfect score (and it's not so easy !) and will send that person some delicious Swiss chocolate !

    Links have been added from SWISS-PROT to the Saccharomyces genomic database (SacchDb) at Stanford.

    A new SWISS-PROT document has been added, it is a nomenclature and index of allergen sequences.

    May 26, 1995
    A new service is available: SWISS-2DSERVICE. The Two-Dimensional Gel Electrophoresis Laboratory of Geneva, Switzerland, is running a highly reproducible method for the two-dimensional separation of proteins. The laboratory now provides a 2-D PAGE service to which you may send your samples for analysis. This service includes analytical and preparative high-resolution 2-D PAGE, electrotransfer on membranes and/or amino acid composition.

    May 17, 1995
    New link in the Tools page to the multiple sequence alignment at Washington University.

    May 11, 1995
    Two links have been added to the SWISS-PROT entries. The first one directly submits a request to Swiss-Model for a 3D model of the current SWISS-PROT protein. The result is then sent back by e-mail. The second one allows to perform a sequence alignment with the current sequence, using NCBI's Basic Local Alignment Search Tool. This link is especially interesting in the virtual SWISS-PROT entries produced by the Translate tool.

    May 5, 1995
    We announce a new service, SWISS-FLASH, that reports news of databases, software and services developments from the Swiss biocomputing groups responsible for the ECD, ENZYME, LISTA, PROSITE, SeqAnalRef, SWISS-2DPAGE, SWISS-3DIMAGE and SWISS-PROT databases; the Melanie software package; the WWW ExPASy server; the SWISS-Model, SWISS- Shop and other network-based computational tools; and the SWISS-2DSERVICE services. If you subscribe to this service, you will automatically get the SWISS-Flash bulletins by electronic mail.

    The SWISS-3DIMAGE database has been completely reorganised and indexed. The database is now searchable in the same way as the other SWISS-*** databases. We now also supply pictures in JPEG format, in addition to GIF and SGI. The images may still be downloaded by FTP.

    Links to REBASE points now the version maintained at John Hopkins, whose layout is nicer than our own text based version !

    April 19, 1995
    We added Translate, a new tool which allows the translation of a nucleotide (DNA/RNA) sequence to a protein sequence.

    Most of the pages in the server have been "refreshed" to make them more readable.

    March 21, 1995
    Links have been added from SWISS-PROT to the LISTA database of budding yeast (Saccharomyces cerevisiae) genes coding for proteins prepared under the supervisation of Patrick Linder.

    March 7, 1995
    Links have been added from SWISS-PROT to the HSSP database of structure-sequence alignments from the Protein Design Group, EMBL, Heidelberg.

    March 2, 1995
    During the last two months, various links have been added:

    Links from SWISS-PROT to FlyBase use the new WWW server for that database.

    Many new SWISS-PROT documents have been added.

    The page on the Melanie 2-D PAGE analysis software has been completely redesigned and includes now a on-line tutorial, as well as a request for information form.

    December 7, 1994
    In order to help users navigate through the ExPASy server, we have added graphical examples. More will be added in the future. See for example: Celegans examples or the who's who on ExPASy page. Thanks to Brigitte Boeckmann for the illustrations.

    October 31, 1994
    ENZYME: the ENZYME Data Bank has been added to the ExPASy server. This database may be accessed by EC number, name, compound, cofactor, comment, or by browsing through the list of classes, subclasses and sub-subclasses. Any entry in SWISS-PROT that contains an EC number in the DE line has also a direct link to ENZYME (by clicking on the EC number).

    October 20, 1994
    New services:

    Compute pI/Mw: the tool to compute pI and Mw now accepts also a list of ID/AC's.

    SWISS-PROT: in PDB cross-reference lines, there is now a link called RASMOL, sending the PDB entry as a chemical / pdb MIME type. On Unix systems, if you add, in the file .mailcap in your home directory, a line of the form

    chemical/pdb; rasmol %s
    then RASMOL will automatically be launched to display the protein 3D structure. This works also with any other program which accepts PDB coordinates. On systems other than Unix, this may also be specified. See your browser's manual.

    October 13, 1994
    The SWISS-PROT top page has been re-modeled. A number of new functionalities and documents have been added.

    October 7, 1994
    New tools have been added:

    October 5, 1994
    The gels run during the 2-D PAGE courses in Geneva are now displayed on the server.

    September 29, 1994
    SWISS-2DPAGE: protein maps now have a pI/Mw scale.

    SeqAnalRef: the Sequence Analysis Bibliographic Reference database has been added to the ExPASy server. This database may be accessed by keyword, by reference identifier, by author and by full text search.

    List of on-line experts: in SWISS-PROT and PROSITE top pages, a list of on-line experts gives you the possibility to directly send questions to any of the listed experts. The list is ogranized by subjects.

    SWISS-PROT: new lists added:

    PROSITE: new 3D line with active links to PDB.

    September 26, 1994
    In the tool AACompIdent for identifying a protein by its amino acid composition, options have been added. They allow to specify how many proteins should be displayed, as well as the pI and Mw range in which the search should be performed.

    Also, some old bugs have now been corrected.

    September 12, 1994
    The tool AACompIdent for identifying a protein by its amino acid composition, has been corrected and is now supposed to work. If you still encounter problems, please send us a mail.

    June 17, 1994
    SWISS-PROT: added cross-references (DR lines) to GenBank.

    June 16, 1994
    SWISS-PROT: added cross-references (DR lines) to MaizeDB Maize Genome Database of the National Agricultural Library.

    June 6, 1994
    Added the PROSITE page: PROSITE entries may now be searched by description of sites and pattern, by accession number, by author, and soon by full text search.

    June 3, 1994
    Added the GuessProt tool to the tools page: you may now get the SWISS-PROT proteins closest to a given pI and Mw.

    May 27, 1994
    In SWISS-PROT entries, added links to GCRDb - the G-Protein--Coupled Receptor DataBase.

    Added the list of nomenclature related references for proteins to the SWISS-PROT top page.

    May 26, 1994
    Added a new reference 2-D PAGE map of Platelet to SWISS-2DPAGE.

    May 20, 1994
    The SWISS-2DPAGE team is now organizing a 2-D PAGE training in Geneva once every three months.

    May 18, 1994
    Added the Yeast Chromosome XI list of proteins to the SWISS-PROT documentation page.

    May 11, 1994
    Tools: new page giving access to on-line analysis tools, such as BLAST, BLITZ, PROSITE search and amino acid composition analysis, and more to come in the future.

    March 23, 1994
    Added the list of restriction enzymes and methylases in SWISS-PROT top page.

    March 22, 1994
    The ExPASy WWW server has been upgraded to a SPARCServer 10/51. It should perform much faster now. If some features are not working, please tell us about.

    March 18, 1994
    The links to OMIM are now direct links to the OMIM hypertext server from GDB. Thanks to Keith Robison for informing me about it.

    March 4, 1994
    SWISS-2DPAGE: Added experimental Amino Acid Composition Similarity Search: you enter a protein's amino acid composition and the server will e-mail you the list of SWISS-PROT entries with similar compositions, sorted by decreasing similarity measure.

    March 2, 1994
    Added direct link to NCBI's BLAST Basic Local Alignment Search Tool (ExPASy and SWISS-PROT top pages).

    March 1, 1994
    Starting with release 28, SWISS-PROT keyword search will be performed on the main release as well as on the weekly updates.

    In the SWISS-PROT page, added links to four additional active lists:

    February 23, 1994
    Added two new reference 2-D PAGE maps: Macrophage Like Cell Line (U937) and Erythroleukemia Cell (ELC).

    In a SWISS-2DPAGE entry, it is now possible to compute the theoretical pI and Mw of the protein.

    February 14, 1994
    Added SWISS-2DPAGE Map Selection: you select a 2-D PAGE reference gel, click on a spot and get information on the corresponding protein. See the SWISS-2DPAGE top page.

    February 11, 1994
    Added a new reference 2-D PAGE map of Cerebrospinal Fluid to SWISS-2DPAGE.

    January 28, 1994
    Added the bionet newsgroups.

    January 25, 1994
    Added an entry to SWISS-3DIMAGE images of crystallized proteins.

    In SWISS-PROT entries which contain cross-references to PDB, added a cross-reference to SWISS-3DIMAGE. Try for example AAT_ECOLI.

    January 24, 1994
    Added full text search of the SWISS-PROT protein sequence database.

    January 17, 1994
    Added links to MEDLINE entries in SWISS-PROT, through NCBI's Entrez Server.

    Added, in the SWISS-2DPAGE page, a link to the QUEST Protein Database Center.

    December 1, 1993
    Added a User Survey. Please help us inprove the server in participating to this survey.

    Added a new reference 2-D PAGE map of Lymphoma to SWISS-2DPAGE.

    November 23, 1993
    Added link to BioBit 24, the BIO-NAUT Newsletter from November, 22, 1993, describing the World Wide Web.

    November 18, 1993
    Added links to the Maize Genome Database at Columbia, Missouri and to EMBnet Switzerland.

    November 17, 1993
    Added the list of overall Top Ten users in the ExPASy server Activity Reports page.

    November 16, 1993
    Added Images of crystallized proteins from this server.

    Added links to Harvard Biological Laboratories, the Gene-Server at University of Houston, the EMBnet: Biocomputing in Europe, the biology servers index at USGS, Jackson Laboratory WWW server and Keith Robison's Molecular Biology WWW sampler.

    October 12, 1993
    Added a list of specialised documents to the SWISS-PROT top page, such as 7-transmembrane G-linked receptors, CD nomenclature for surface proteins of Human leucocytes and Vertebrate homeobox proteins. Some of these list give then direct access to corresponding SWISS-PROT entries.

    October 8, 1993
    Added links to the Caenorhabditis elegans and Mycobacterium databases at INRA (France).

    Added a link to the ExPASy server activity reports.

    October 4, 1993
    Moved to the NCSA server.

    September 28, 1993
    Added the PDB Brookhaven Protein Data Bank of 3D structures. In SWISS-PROT, cross-references to PDB have now active links to the gopher server at Protein Data Bank. You may access the PDB entry or get the 3D image. Try for example the SWISS-PROT entry P00782.

    September 27, 1993
    Added the FlyBase database of genetic and molecular data for Drosophila. In SWISS-PROT and EMBL, cross-references to FLYBASE are now active links. Therefore, SWISS-PROT has now active links to SWISS-2DPAGE, EMBL, PROSITE, REBASE, OMIM and FLYBASE. EMBL has active links to SWISS-PROT and FlyBase.

    September 23, 1993
    Added a link to the National Institute of Health Genobase server to our top page.

    September 21, 1993
    Announced the ExPASy server and SWISS-2DPAGE release 0 to bionet.announce.

    August 1, 1993
    Installed the ExPASy molecular biology server, release 0, beta version.

    Last modified 21/Mar/2003 by ELG
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